Repairing Marginal Kidneys With Mitochondrial Transplantation: A New Powerful Tissue Engineering Tool That Will Change the Transplant Landscape
Dr. Giuseppe Orlando, Wake Forest University, USA, will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Repairing Marginal Kidneys With Mitochondrial Transplantation: A New Powerful Tissue Engineering Tool That Will Change the Transplant Landscape".
The lecture will illustrate the state of the art of kidney transplantation and the role that mitochondrial transplantation will have in increasing the donor pool.
It is predicted that mitochondrial medicine will dramatically increase the number of transplantable organs by offering a valuable technology that will enable transplantation to repair marginal allografts. The organ preservation and repair platform should therefore be seen by the mitochondrial society as a formidable platform offered by transplant medicine for the application of mitochondria-based technologies
Join Targeting Mitochondria 2023 to learn more about Dr. Orlando's exciting talk. Read more about Dr. Orlando's latest promising findings.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
Targeting MCJ/DnaJC15 to modulate mitochondrial respiration in disease
Dr. Mercedes Rincon, University of Colorado Anschutz School of Medicine, USA will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Targeting MCJ/DnaJC15 to modulate mitochondrial respiration in disease".
Dr. Rincon and her team have identified MCJ (also called DnaJC15) as a novel negative regulator of mitochondrial metabolism. MCJ associates with Complex I of the ETC, and acts as a negative regulator of Complex I and mitochondrial respiration. MCJ deficiency results in increased mitochondrial respiration, but it has no effect on glycolysis and does not increase the production of reactive oxygen species (ROS).
Dr. Rincon will present their studies showing that MCJ is emerging as a target for non-alcoholic fatty liver disease (NAFLD), and how silencing of MCJ in hepatocytes can be a safe therapeutic strategy for treatment of this and other mitochondria-mediated liver diseases. She will also describe how loss of MCJ in cancer cells leads to chemotherapy resistance due to increased mitochondrial respiration and how MCJ mimetics can overcome chemoresistance.
Join Targeting Mitochondria 2023 to learn more about Dr. Rincon's exciting talk. You can submit a related abstract here.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
The Power of Epigenetics: The Patterns of mitoDNA Methylation Transmitted Across Generation
Dr. Marc-André Sirard, Director of the Center for Research in Reproduction, Development and Intergenerational Health at Université Laval, Canada , will share his latest findings via a major talk at Targeting Mitochondria 2023.
Mitochondria are only inherited through the oocyte and the metabolic environment is also transmitted through epigenetic mechanism in mammals.
Dr. Sirard and his team have evidence that DNA methylation in the mitochondrial and genomic DNA might play a role in the programming of gene expression in the next generation. Genomic studies indicate a gene regulation impact of the mitochondrial genome associated methylation levels using the bovine oocyte-embryo model.
Dr. Sirard's talk will be titled "The Power of Epigenetics: The Patterns of mitoDNA Methylation Transmitted Across Generation".
You can learn more about this topic and benefit from the experience of Dr. Sirard by joining Targeting Mitochondria 2023.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
Targeting Mitochondria 2023 Best Poster Presentation Award for Young Investigator
It gives us immense pleasure to announce that Tatjana Kuen from Leopold-Franzens Universität Innsbruck, Austria, has been distinguished with the Targeting Mitochondria 2023 Best Poster Presentation Award for Young Investigators.
Her poster, titled "Inhibitors of Fumarylacetoacetate Domain Containing Protein 1 (FAHD1) Induce Premature Cellular Senescence in Human Endothelial Fibroblasts in Vitro," delves into the intricate role of FAHD1 as an oxaloacetate decarboxylase in the TCA cycle regulation. Notably, the findings revealed that a lentiviral knockdown of FAHD1 could lead HUVEC cells into premature cellular senescence. The proposed model suggests a mitochondrial dysfunction-associated senescence-like phenotype that is potentially mediated through the reduction of complex-II activity. Currently, Tatjana and her team are exploring the use of second-generation FAHD1 inhibitors to replicate this intriguing effect.
Join us in extending heartfelt congratulations to Tatjana Kuen for this outstanding achievement.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
wms-site.com
2023 Best Short Oral Presentation Award
Targeting Mitochondria 2023 Best Short Oral Presentation Award #1
The World Mitochondria Society congratulate Dr. Ioannis Tsichlis from the National & Kapodistrian University of Athens, Greece, for earning the Best Short Oral Presentation award at Targeting Mitochondria 2023.
Dr. Tsichlis's profound talk, titled "Development of Mitochondria-Inspired Lipopolyplexes for Gene Delivery," was a deep dive into the cutting-edge realm of gene therapy.
He presented a novel mitochondrial-inspired nanosystem, which incorporated the properties of mitochondria into hybrid lipopolyplexes. These meticulously crafted structures are geared towards efficient gene delivery, offering a potential leap in therapeutic interventions. Particularly noteworthy was their remarkable stability across various media, an essential characteristic for real-world applications.
His talk was a testament to his dedication and innovative approach in the field of targeting mitochondria.
Dr. Tsichlis shared with the World Mitochondria Society: "Following the successful development of mitochondria-inspired lipopolyplexes, our research involves in vitro cytotoxicity studies and in vivo biological experiments in the well-established C. elegans model to evaluate the specificity and efficiency of the nanoplatform in targeting mitochondria. The ultimate goal is to develop a safe and effective bio-inspired gene delivery nanoplatform that will contribute to mitochondrial gene therapy."
All our congratulations.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
wms-site.com
2023 Best Short Oral Presentation Award
Targeting Mitochondria 2023 Best Short Oral Presentation Award #2
The World Mitochondria Society celebrates Sami Noujaim from the University of South Florida, USA, for clinching the Targeting Mitochondria 2023 Best Short Oral Presentation Award.
Dr. Noujaim's insightful talk, "Mitochondrial Involvement in Cardiac Electrophysiological Injury Due to Inhalation Exposure to Electronic Nicotine Delivery Systems (ENDS)," delved into the alarming effects of vaping on heart electrophysiology.
He expertly highlighted the role of adverse mitochondrial changes and increased oxidative stress in these effects.
All our congratulations.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
wms-site.com
2023 Best Scientific Contribution Award at Targeting Mitochondria 2023
Dr. Naig Gueguen from the Mitovasc Institute has been recognized with the coveted 2023 Best Scientific Contribution Award, a testament to her role as a trailblazing scientist in the field.
In her excellent workshop titled "How to Evaluate Mitochondrial Function," Dr. Gueguen, affiliated with INSERM 1083, CNRS 6215, and Centre Hospitalier Universitaire d’Angers, showcased the depth of her expertise.
She navigated through the nuances of mitochondrial study, touched on key technological tools, delved into critical markers, elucidated diverse techniques for examination, presented diagnostic approaches, and shared invaluable case studies centered on mitochondrial anomalies.
The WMS extends its heartfelt congratulations to Dr. Gueguen for her stellar contributions and presentation.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
wms-site.com
Emerging Trends & Strategies: 15th World Congress 2024
Join us in Berlin from October 29-31, 2024, for the 15th World Congress on Targeting Mitochondria.
Targeting Mitochondria 2024: New Visionary Approaches
The President of the World Mitochondria Society, Volkmar Weissig, and the Chairman of the Scientific Board, Marvin Edeas, have highlighted the complexities involved in curating an agenda and identifying suitable speakers as significant challenges. In response, they are adopting a progressive and "out of the box" perspective.
Volkmar Weissig and Marvin Edeas aim to take an unconventional approach by concentrating on Emerging Trends and Strategies in mitochondrial research. To this end, they have selected topics such as exosomes and extracellular vesicles, the application of artificial intelligence, the mitochondria-microbiota interplay, the role of mitochondria in photomedicine, and exploratory discussions on the incorporation of Chinese medicine principles.
Summary of the Agenda
Day 1 - Tuesday, October 29, 2024: Mitochondria Workshop
- Workshop Title: “How to Evaluate Mitochondria Function? Bridging Theory and Practice”
- Led by: Dr. Naïg Gueguen, MitoVasc Institute, Angers University Hospital Center, France.
- Focus on methodologies and techniques for assessing mitochondrial function accurately.
Day 2 - Wednesday, October 30, 2024: Keynote and Sessions
Keynote Presentation: “The Mitochondrial Kingdom: Historical Moments, Evolutionary Insights, Current Understanding, and Future Projections.”
Session 1: Mitochondrial Biodynamics in Health and Diseases
- Topics include mitochondrial mitophagy and biogenesis, mitochondria in cancer, aging, cell communication, and the interconnections between iron, ferritin, and mitochondria.
Session 2: Evaluation and Quality Control of Mitochondrial Function
- Highlights innovations in mitochondrial function measurement, real-time visualization techniques, new monitoring devices, and quality control mechanisms.
Day 3 - Thursday, October 31, 2024: Continuing Sessions and Concluding Remarks
Session 3: 15th World Mitochondria Society Meeting on Emerging Trends and Strategies
- Covers exosomes and extracellular vesicles, AI in research, mitochondria-microbiota interplay, updates on mitochondria in photomedicine, and considerations of Chinese medicine.
Session 4: Mitochondrial Medicine 2024: From Bench to Bedside
- Focuses on practical applications like mitochondrial transplantation, transfer & tunneling nanotubes, pharmaceutical approaches, and the latest clinical studies targeting mitochondria.
Concluding Remarks & Awards:
- Summarizing key takeaways, next steps in mitochondrial research, and recognizing outstanding contributions.
It will be a great pleasure to meet you in Berlin next October for this exciting congress!
Sincerely,
Prof. Volkmar Weissig
President of the World Mitochondria Society
Midwestern University, USA
On behalf of the WMS Scientific Board
