Metabolic effects of Cimicfuga racemosa extract on mitochondria and implications for the resistance against oxidative cell death and longevity
Prof. Carsten Culmsee, active member of the scientific committe and from the University of Marburg, Germany, will join Targeting Mitochondria 2023 this October. He will have a talk entitled "Metabolic effects of Cimicfuga racemosa extract on mitochondria and implications for the resistance against oxidative cell death and longevity".
Cimicifuga racemosa extract (CRE) is a well-established herbal medication to treat menopausal symptoms such as hot flashes and weight gain. In contrast to estrogen replacement therapy or phytoestrogens, however, CRE does not act through stimulation of estrogen receptors but through metabolic mechanisms. Prof. Culmsee and his team's findings suggest that CRE Ze 450 rather exerts direct effects on mitochondrial energy turnover through interference with components of the mitochondrial electron transport chain (ETC).
Prof. Culmsee will provide a comprehensive insight into the signalling effects of the extract on the mitochondrial proteome and metabolome, highlighting the role of CREe for the resilience against age-related processes engaging impaired mitochondria and loss of antioxidative capacities.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
Vladimir Skulachev's Strategic Impact on Mitochondrial Medicine: A Tribute to his Vision, Discoveries, and Legacy
Prof. Vladimir Gogvadze, Karolinska Institutet, Sweden, and active member of the scientific committe will join Targeting Mitochondria 2023 this October and introduce the congress.
Prof. Gogvadze will dedicate his talk to Prof. Vladimir Skulachev, former member of the scientific committee of WMS, to recognize his impact in the Mitochondria World: "Vladimir Skulachev's Strategic Impact on Mitochondrial Medicine: A Tribute to his Vision, Discoveries, and Legacy".
Read more about Professor Skulachev's impact.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
Advances in the Development of Mitochondria-Targeted Pharmaceuticals
Dr. Maxim Skulachev, CSO at Mitotech (Israel) , who manages Mitotech's core scientific research, will share the latest advances in developing mitochondria targeting drugs during Targeting Mitochondria 2023 this October.
In the last 15 years of his life and scientific career, Vladimir Skulachev dedicated himself to his project on practical application of penetrating ions. This ambitious endeavor focuses on developing new pharmaceuticals based on mitochondria-targeted antioxidants of the SkQ class.
Mitotech's leading compound, SkQ1, is currently undergoing extensive development for different indications and in various pharmaceutical forms, including eye drop formulations (which have reached the third stage of clinical trials in the US), as well as oral and injectable "systemic" formulations.
In this presentation, Dr. Skulachev would like to share their recent findings from preclinical studies they completed using the latter formulations, Mitotech team successfully harnessed both the antioxidant and mild uncoupling properties of SkQ1 molecule.
Dr. Skulachev's short talk will be titled: "Advances in the Development of Mitochondria-Targeted Pharmaceuticals".
Read more about Professor Vladimir Skulachev's impact.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
What spaceflight and bed rest have in common: A proteomic point of view
Dr. Marta Murgia from the University of Padova, Italy will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "What spaceflight and bed rest have in common: A proteomic point of view".
In the absence of mechanical loading, skeletal muscle undergoes atrophy with loss of strength and detrimental metabolic effects. Dr. Murgia and her team used highly sensitive mass spectrometry (MS)-based proteomics to detail single fiber type-specific molecular remodeling caused by muscle unloading, using bed rest as a model.
In parallel, they measured the muscle proteome of two astronauts, from biopsies taken before and after a six months mission on the International Space Station (ISS). In their muscle lysates, they measured a sharp decrease in the expression of the whole mitochondrial proteome.
Dr. Murgia's talk will give an overview of the main proteomic changes that we measured in these two different models of muscle unloading and disuse. She will highlight striking similarities as well as profound differences. She will discuss the protective role of exercise on skeletal muscle mass in space, with a focus on the mitochondrial proteome.
Join Targeting Mitochondria 2023 to learn more about Dr. Murgia's exciting talk. You can submit a related abstract here.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
Mitochondria Organelle Transplantation for Neurological Diseases & Aging
Dr. Mark S. Kindy from the University of South Florida, USA, will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Mitochondria Organelle Transplantation for Neurological Diseases and Aging".
Join Targeting Mitochondria 2023 to learn more about Dr. Kindy's exciting talk.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
Repairing Marginal Kidneys With Mitochondrial Transplantation: A New Powerful Tissue Engineering Tool That Will Change the Transplant Landscape
Dr. Giuseppe Orlando, Wake Forest University, USA, will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Repairing Marginal Kidneys With Mitochondrial Transplantation: A New Powerful Tissue Engineering Tool That Will Change the Transplant Landscape".
The lecture will illustrate the state of the art of kidney transplantation and the role that mitochondrial transplantation will have in increasing the donor pool.
It is predicted that mitochondrial medicine will dramatically increase the number of transplantable organs by offering a valuable technology that will enable transplantation to repair marginal allografts. The organ preservation and repair platform should therefore be seen by the mitochondrial society as a formidable platform offered by transplant medicine for the application of mitochondria-based technologies
Join Targeting Mitochondria 2023 to learn more about Dr. Orlando's exciting talk. Read more about Dr. Orlando's latest promising findings.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
Targeting MCJ/DnaJC15 to modulate mitochondrial respiration in disease
Dr. Mercedes Rincon, University of Colorado Anschutz School of Medicine, USA will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Targeting MCJ/DnaJC15 to modulate mitochondrial respiration in disease".
Dr. Rincon and her team have identified MCJ (also called DnaJC15) as a novel negative regulator of mitochondrial metabolism. MCJ associates with Complex I of the ETC, and acts as a negative regulator of Complex I and mitochondrial respiration. MCJ deficiency results in increased mitochondrial respiration, but it has no effect on glycolysis and does not increase the production of reactive oxygen species (ROS).
Dr. Rincon will present their studies showing that MCJ is emerging as a target for non-alcoholic fatty liver disease (NAFLD), and how silencing of MCJ in hepatocytes can be a safe therapeutic strategy for treatment of this and other mitochondria-mediated liver diseases. She will also describe how loss of MCJ in cancer cells leads to chemotherapy resistance due to increased mitochondrial respiration and how MCJ mimetics can overcome chemoresistance.
Join Targeting Mitochondria 2023 to learn more about Dr. Rincon's exciting talk. You can submit a related abstract here.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
The Power of Epigenetics: The Patterns of mitoDNA Methylation Transmitted Across Generation
Dr. Marc-André Sirard, Director of the Center for Research in Reproduction, Development and Intergenerational Health at Université Laval, Canada , will share his latest findings via a major talk at Targeting Mitochondria 2023.
Mitochondria are only inherited through the oocyte and the metabolic environment is also transmitted through epigenetic mechanism in mammals.
Dr. Sirard and his team have evidence that DNA methylation in the mitochondrial and genomic DNA might play a role in the programming of gene expression in the next generation. Genomic studies indicate a gene regulation impact of the mitochondrial genome associated methylation levels using the bovine oocyte-embryo model.
Dr. Sirard's talk will be titled "The Power of Epigenetics: The Patterns of mitoDNA Methylation Transmitted Across Generation".
You can learn more about this topic and benefit from the experience of Dr. Sirard by joining Targeting Mitochondria 2023.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
