The Power and Potential of Mitochondria Transfer
Dr. Jonathan R. Brestoff, Washington University in St. Louis School of Medicine, USA, will join the 15th WMS Annual Congress on Targeting Mitochondria 2024.
Dr. Brestoff will present his latest research on The Power and Potential of Mitochondria Transfer.
Join Targeting Mitochondria 2024 to learn more about the latest advances in mitochondrial transfer.
About Jonathan R. Brestoff
Jonathan R. Brestoff, M.D., Ph.D., M.P.H., is an assistant professor of pathology and immunology at Washington University School of Medicine (WUSM). He completed his M.D./Ph.D. at the Perelman School of Medicine at the University of Pennsylvania with Dr. David Artis, where Dr. Brestoff’s work identified that group 2 innate lymphoid cells induce beige fat to limit the development of obesity. He then moved to WUSM in 2016 for his residency in pathology, during which time Dr. Brestoff completed his postdoctoral training with Dr. Steven Teitelbaum. For his research on a process called intercellular mitochondria transfer, Dr. Brestoff was awarded the NIH Director’s Early Independence Award and Burroughs Wellcome Fund Career Award for Medical Scientists, allowing him to launch his independent laboratory at WUSM in 2019. His lab continues to study immunometabolism and intercellular mitochondria transfer, leading to his lab’s pioneering studies on mitochondria transfer from adipocytes to macrophages, which was named in Cell Metabolism’s Best of 2021 special issue. His work on these subjects has been published in Nature, Cell, Science, Cell Metabolism, Nature Immunology, Nature Metabolism, and other top journals. He is a member of the scientific advisory board for LUCA Science, Inc., based in Tokyo, and is a trustee at his alma mater, Skidmore College.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
October 28-30, 2024 - Berlin, Germany
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Mitochondria Function Evaluation: Workshop Highlights, Methods, Discrepancies, and Recommendations
Dr. Naig Gueguen, CHU Angers, France, will join the 15th WMS Annual Congress on Targeting Mitochondria 2024.
Dr. Gueguen will present the following contribution: "Mitochondria Function Evaluation: Workshop Highlights, Methods, Discrepancies, and Recommendations".
This presentation will summarize the workshop she will host on October 29 about Mitochondrial Evaluation.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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State of the Science Mitochondria-specific Targets, Therapeutics and Biomarkers Investigation following Traumatic Brain Injury in the US Military
It is a great pleasure to welcome Dr. Jignesh D. Pandya, Walter Reed Army Institute of Research, USA, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: State of the Science Mitochondria-specific Targets, Therapeutics and Biomarkers Investigation following Traumatic Brain Injury in the US Military.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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Mitochondrial Dynamics: Updates and Perspectives
It is a great pleasure to welcome Dr. Ježek Petr, Institute of Physiology of the Czech Academy of Sciences, Czech Republic, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondrial Dynamics: Updates and Perspectives.
Highlights
- Mitochondrial network facilitates rejuvenation of fragments and communication via exosomes.
- Mitochondrial cristae morphology changes with metabolism and oxidative phosphorylation (OXPHOS).
- INS-1EΔe+g cells showed lower ATP synthesis, inhibited insulin secretion (IS), and distinct mitochondrial cristae structures.
- Exosomes from stressed pancreatic cells may communicate stress responses.
- Regular mitochondrial cristae can form without major FO subunits of ATP-synthase.
- Delayed mitophagy in IS-impaired cells might lead to exosomes signaling pathology.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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Role of Light in Regulating Blood Glucose via Mitochondrial Stimulation
It is a great pleasure to welcome Dr. Michael B. Powner, City University of London, United Kingdom, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Role of Light in Regulating Blood Glucose via Mitochondrial Stimulation.
About Michael B. Powner
Dr. Michael Powner is a Senior lecturer in Neurobiology, joining the Optometry division at City, University of London in February 2016. Dr. Powner is a neurobiologist who explores the mechanisms behind cellular stress during the early stages of retinal diseases; including age related macular degeneration (AMD) and diabetic retinopathy. He is also passionate about developing or adapting non invasive interventions, including optical and electrical stimulation, to improve patients health and quality of life.
In collaboration with Prof. Jeffery at UCL Institute of Ophthalmology, he is investigating the potential of red light (670nm) as a therapy for aging and ocular diseases, including age related macular degeneration.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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Investigating Mitochondria as Age-Old Drivers of Inflammation
It is a great pleasure to welcome Dr. Stephen Tait, University of Glasgow, United Kingdom, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Investigating Mitochondria as Age-Old Drivers of Inflammation.
Stephen Tait's Research Interest
Cell death is a key tumour suppressor mechanism that must be inhibited in order for cancer to develop. Sensitivity to cell death also governs therapeutic efficacy because anti-cancer therapies often act by killing cells. The major form of programmed cell death is apoptosis, a process in which mitochondria play an essential role.
His research focuses upon understanding how mitochondria control cell death and addressing how this is deregulated in cancer. Clinical translation of our findings should lead to improvements of existing therapies and development of new approaches to enable tumour selective killing.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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Targeting Giant Mitochondria (Megamitochondria) in Human Liver Disease: Potential Diagnostic and Therapeutic Interventions
It is a great pleasure to welcome Dr. Elena Palma, King's College London, United Kingdom, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Targeting Giant Mitochondria (Megamitochondria) in Human Liver Disease: Potential Diagnostic and Therapeutic Interventions.
Key Points
- Megamitochondria are disproportionately enlarged organelles with regular paracrystalline inclusions.
- Their significance and how they form are still under debate.
- Their detection has strikingly been linked to improved survival among patients with Alcohol-related liver disease.
- New models are needed to investigate this intriguing phenomenon and human precision cut liver slices represent a crucial advance for this purpose.
About Elena Palma
One of Dr. Palma's interests is developing ex vivo experimental models to study liver diseases and malignancies, using dynamic cultures of human precision-cut tissue slices.
Her research investigates the role of mitochondria in the pathogenesis and progression of Alcohol-related liver diseases with the final aim to target these organelles for therapeutic purposes.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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Mitochondria Iron Metabolism: Its Role in Pathogenesis of Diseases
It is a great pleasure to welcome Dr. Sonia Levi, Vita-Salute San Raffaele University, Italy, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondria Iron Metabolism: Its Role in Pathogenesis of Diseases
In her talk Dr. Levi will cover the following:
- Discuss the importance of iron in the physiology of mitochondria.
- Mitochondria as the critical controllers of cellular iron homeostasis and their involvement in the mechanism of ferroptosis, an iron-dependent form of cellular death driven by lipid peroxidation.
- Example of how mitochondrial iron-deficiency and -overload impair mitochondrial metabolism, promoting disease development.
- Focus on mitochondrial iron-imbalance role in the initiation and progression of neurodegenerative diseases.
More information on Dr. Mysorekar's latest research.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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