New Biosensing Solutions and Optimized Pharmacological Inhibitors to Counteract Mitophagy in Cancer Cells
It is a great pleasure to welcome Dr. Giulia Bertolin, Université de Rennes, France, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: New Biosensing Solutions and Optimized Pharmacological Inhibitors to Counteract Mitophagy in Cancer Cells
Highlights
- Mitochondria play vital roles in cell physiology, and dysfunctions are implicated in diseases like cancer and neurodegenerative disorders.
- Mitochondria are closely integrated with other cellular components, impacting functions such as cell cycle regulation and ATP production.
- The talk will explore how cancer cells exploit mitochondrial functions, focusing on the cell cycle protein AURKA, which is often overexpressed in breast cancer.
- Advanced fluorescence microscopy techniques are utilized to track AURKA activation in living samples, providing insights into its role in mitochondrial function.
- Ongoing research aims to develop sensitive biosensors for monitoring mitochondrial activation of AURKA and exploring pharmacological inhibitors to alter its interaction with mitophagy partners.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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