Emerging Trends & Strategies: 15th World Congress 2024

linkedin-post-slide

Join us in Berlin from October 28-30, 2024, for the 15th World Congress on Targeting Mitochondria. 

Targeting Mitochondria 2024: New Visionary Approaches

The President of the World Mitochondria Society, Volkmar Weissig, and the Chairman of the Scientific Board, Marvin Edeas, have highlighted the complexities involved in curating an agenda and identifying suitable speakers as significant challenges. In response, they are adopting a progressive and "out of the box" perspective.

Volkmar Weissig and Marvin Edeas aim to take an unconventional approach by concentrating on Emerging Trends and Strategies in mitochondrial research. To this end, they have selected topics such as exosomes and extracellular vesicles, the application of artificial intelligence, the mitochondria-microbiota interplay, the role of mitochondria in photomedicine, and exploratory discussions on the incorporation of Chinese medicine principles.


Summary of the Agenda

Day 1 - Monday, October 28, 2024: Mitochondria Workshop

  • Workshop Title: “How to Evaluate Mitochondria Function? Bridging Theory and Practice” 
  • Led by: Dr. Naïg Gueguen, MitoVasc Institute, Angers University Hospital Center, France.
  • Focus on methodologies and techniques for assessing mitochondrial function accurately.

Day 2 - Tuesday, October 29, 2024: Keynote and Sessions

Keynote Presentation: “The Mitochondrial Kingdom: Historical Moments, Evolutionary Insights, Current Understanding, and Future Projections.”

Session 1: Mitochondrial Biodynamics in Health and Diseases

  • Topics include mitochondrial mitophagy and biogenesis, mitochondria in cancer, aging, cell communication, and the interconnections between iron, ferritin, and mitochondria.

Session 2: Evaluation and Quality Control of Mitochondrial Function

  • Highlights innovations in mitochondrial function measurement, real-time visualization techniques, new monitoring devices, and quality control mechanisms.

Day 3 - Wednesday, October 30, 2024: Continuing Sessions and Concluding Remarks

Session 3: 15th World Mitochondria Society Meeting on Emerging Trends and Strategies

  • Covers exosomes and extracellular vesicles, AI in research, mitochondria-microbiota interplay, updates on mitochondria in photomedicine, and considerations of Chinese medicine.

Session 4: Mitochondrial Medicine 2024: From Bench to Bedside

  • Focuses on practical applications like mitochondrial transplantation, transfer & tunneling nanotubes, pharmaceutical approaches, and the latest clinical studies targeting mitochondria.

Concluding Remarks & Awards:

  • Summarizing key takeaways, next steps in mitochondrial research, and recognizing outstanding contributions.

Learn more about the program.


It will be a great pleasure to meet you in Berlin next October for this exciting congress!

Sincerely,

Prof. Volkmar WeissigProf. Volkmar Weissig
President of the World Mitochondria Society
Midwestern University, USA
On behalf of the WMS Scientific Board

 

Mitochondrial Innovations Workshop: Bridging Theory and Practice

Cover-2024-updated 2

The World Mitochondria Society has scheduled an annual workshop on the Evaluation of Mitochondrial Function, led by Dr. Naig Gueguen, for October 28 in Berlin, preceding the Targeting Mitochondria 2024 conference.

Aims & Objectives

  • Focus: Investigation of mitochondrial function, dysfunction, and activities.
  • Purpose: To advance comprehension of mitochondria, metabolism, and bioenergetics.
  • Content: Features technological instruments, biomarkers, and diagnostic methodologies for mitochondrial diseases.
  • Application: Incorporates practical cases for experiential learning and insight.

Intended Audience

  • Medical practitioners, biologists, geneticists, researchers in fields including oncology, neuroscience, pediatrics, metabolic diseases, and others.
  • R&D directors, engineers, research assistants, business executives, and individuals interested in mitochondria, metabolism, bioenergetics, and therapeutic advancements.

Post-Workshop Materials

  • A comprehensive PDF report summarizing workshop proceedings.
  • A bibliography and additional resources for extended learning.

WMS 2024 Workshop: Topics & Sessions

Session 1: Bioenergetics

  • Analysis methods for mitochondrial function including respiratory chain activity and oxidative metabolism.
  • Technological tools for research in vitro, in vivo, and ex vivo.
  • Discussion covers respiration rates, mitochondrial membrane potential, ATP synthesis, and redox states.

Session 2: Biogenesis, Dynamics, and Mitophagy

  • Techniques for examining mitochondrial networks and mitophagy.

Session 3: Practical Insights into Mitochondrial Function

  • Diagnosing mitochondrial disorders
  • Parctical case presentations:
  1. Mitochondrial function in models of longevity.
  2. Mitochondrial activity in the context of skin aging and skincare.

Dr. Naig Gueguen, affiliated with the Mitovasc Institute, Mitolab team, INSERM 1083, CNRS 6215, at the Centre Hospitalier Universitaire d’Angers, Angers, France, leads the workshop.

Access full workshop program.


World Mitochondria Society
Targeting Mitochondria 2024 Congress

October 28-30, 2024 - Berlin, Germany 
LinkedIn | Facebook

 

2023 Best Scientific Contribution Award at Targeting Mitochondria 2023

WMS 2023 SCIENTIFIC CONTRIBUTION 2

Dr. Naig Gueguen from the Mitovasc Institute has been recognized with the coveted 2023 Best Scientific Contribution Award, a testament to her role as a trailblazing scientist in the field.

In her excellent workshop titled "How to Evaluate Mitochondrial Function," Dr. Gueguen, affiliated with INSERM 1083, CNRS 6215, and Centre Hospitalier Universitaire d’Angers, showcased the depth of her expertise.

She navigated through the nuances of mitochondrial study, touched on key technological tools, delved into critical markers, elucidated diverse techniques for examination, presented diagnostic approaches, and shared invaluable case studies centered on mitochondrial anomalies.

The WMS extends its heartfelt congratulations to Dr. Gueguen for her stellar contributions and presentation.


Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany 
wms-site.com

linkedin-recShare on LinkedIn 

2023 Best Short Oral Presentation Award

WMS BEST ORAL 2 2023

Targeting Mitochondria 2023 Best Short Oral Presentation Award #2

The World Mitochondria Society celebrates Sami Noujaim from the University of South Florida, USA, for clinching the Targeting Mitochondria 2023 Best Short Oral Presentation Award.

Dr. Noujaim's insightful talk, "Mitochondrial Involvement in Cardiac Electrophysiological Injury Due to Inhalation Exposure to Electronic Nicotine Delivery Systems (ENDS)," delved into the alarming effects of vaping on heart electrophysiology.

He expertly highlighted the role of adverse mitochondrial changes and increased oxidative stress in these effects.

All our congratulations.


Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany 
wms-site.com

linkedin-recShare on LinkedIn 

2023 Best Short Oral Presentation Award

WMS BEST ORAL 1 2023

Targeting Mitochondria 2023 Best Short Oral Presentation Award #1

The World Mitochondria Society congratulate Dr. Ioannis Tsichlis from the National & Kapodistrian University of Athens, Greece, for earning the Best Short Oral Presentation award at Targeting Mitochondria 2023.

Dr. Tsichlis's profound talk, titled "Development of Mitochondria-Inspired Lipopolyplexes for Gene Delivery," was a deep dive into the cutting-edge realm of gene therapy.

He presented a novel mitochondrial-inspired nanosystem, which incorporated the properties of mitochondria into hybrid lipopolyplexes. These meticulously crafted structures are geared towards efficient gene delivery, offering a potential leap in therapeutic interventions. Particularly noteworthy was their remarkable stability across various media, an essential characteristic for real-world applications.

His talk was a testament to his dedication and innovative approach in the field of targeting mitochondria.

Dr. Tsichlis shared with the World Mitochondria Society: "Following the successful development of mitochondria-inspired lipopolyplexes, our research involves in vitro cytotoxicity studies and in vivo biological experiments in the well-established C. elegans model to evaluate the specificity and efficiency of the nanoplatform in targeting mitochondria. The ultimate goal is to develop a safe and effective bio-inspired gene delivery nanoplatform that will contribute to mitochondrial gene therapy."

All our congratulations.


Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany 
wms-site.com

linkedin-recShare on LinkedIn 

Targeting Mitochondria 2023 Best Poster Presentation Award for Young Investigator

WMS BEST POSTER 2023 cropped

It gives us immense pleasure to announce that Tatjana Kuen from Leopold-Franzens Universität Innsbruck, Austria, has been distinguished with the Targeting Mitochondria 2023 Best Poster Presentation Award for Young Investigators.

Her poster, titled "Inhibitors of Fumarylacetoacetate Domain Containing Protein 1 (FAHD1) Induce Premature Cellular Senescence in Human Endothelial Fibroblasts in Vitro," delves into the intricate role of FAHD1 as an oxaloacetate decarboxylase in the TCA cycle regulation. Notably, the findings revealed that a lentiviral knockdown of FAHD1 could lead HUVEC cells into premature cellular senescence. The proposed model suggests a mitochondrial dysfunction-associated senescence-like phenotype that is potentially mediated through the reduction of complex-II activity. Currently, Tatjana and her team are exploring the use of second-generation FAHD1 inhibitors to replicate this intriguing effect.

Join us in extending heartfelt congratulations to Tatjana Kuen for this outstanding achievement.


Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany 
wms-site.com

linkedin-recShare on LinkedIn 

World Mitochondria Society Task Force: Call For Strategic Projects

We have the pleasure to announce the formation of the WMS Task Force, a groundbreaking initiative committed to driving innovation and reshaping the landscape of mitochondria research in health and diseases.

WMS-TaskForce-Logo-V3


The Aim of WMS Task Force

Through the establishment of a cooperative environment, this Task Force aims to address the challenges that impede the understanding, prevention and treatment of diseases related to mitochondria. It is a platform where knowledge and expertise are freely shared, fostering an atmosphere conducive to significant advancements in mitochondria research in health & diseases.

Our vision of establishing a Task Force that brings together multidisciplinary experts, which is crucial for pushing the boundaries of mitochondrial research and innovation. By fostering a collaborative environment, we can collectively address challenges, share knowledge and expertise, and drive advancements in the understanding of mitochondria research and related diseases.


WMS Task Force Projects

The WMS Task Force is launching 2 projects for the improvement of mitochondrial research and applications:

1- Mitochondrial Transfer & Tunneling Nanotubes (TNTs). Read more.

2- Mitochondrial Oscillation and Resonance: Impact on ATP Production and Distribution in Health and Diseases. Read more.


The Funding

In terms of funding, the WMS Task Force is prepared to submit the selected projects to both public and private institutions. The objective is to secure the necessary resources to fuel these projects, and ensure the sustainability and longevity of the task force.

The collected funding will be distributed to all teams invovled in the Task Force.


How to Join the Task Force & Structure your Project Proposal?

To contribute to one of these 2 pioneering projects, the WMS requests interested researchers and teams to submit a proposal detailing the following aspects:

· Project Overview:
Please provide a concise description of your current research or project. Include key goals, methodologies used, and any preliminary results or findings that could highlight the relevance and potential impact of your work.

· Alignment with Task Force Goals:
Articulate how your work contributes to the broader objectives of the task force. This could be in terms of techniques being developed, the specific aspects of mitochondrial transfer your project focuses on, or the potential applications of your research.

· Challenges and Solutions:
Identify any potential hurdles or obstacles you anticipate in the course of your research. This could be technical issues, logistical constraints, or theoretical problems. Additionally, provide an outline of how you propose to tackle these challenges. This shows proactive problem-solving and can help us better understand the feasibility of your project.

· Team Profile:
Furnish an overview of your team and its expertise. Highlight the skills, qualifications, and experiences of your team members that make them well-equipped to carry out the proposed project. Include any past achievements or relevant projects that demonstrate your team’s capacity to successfully execute the research.


How to Submit?

Please submit your projects and details above to:

· Prof. Volkmar Weissig, President of the WMS

· Prof. Marvin Edeas, Chairman of the Scientific Committee

- At the following email address: mitochondria(at)wms-site.com. 

- Deadline for the submission: March 12, 2024.  

Applications will be reviewed by the Task Force Selection Committee, and successful applicants will be contacted to proceed to the next stage of the process. Please note that acceptance into the task force is competitive, and only a select number of applicants will be chosen to join.

We look forward to your valuable input and collaboration in this groundbreaking endeavor.


Mitochondria-logo-originalWorld Mitochondria Society
Targeting Mitochondria Congress

 

 

The Power of Epigenetics: The Patterns of mitoDNA Methylation Transmitted Across Generation

SIRARD Marc-AndréDr. Marc-André Sirard, Director of the Center for Research in Reproduction, Development and Intergenerational Health at Université Laval, Canada , will share his latest findings via a major talk at Targeting Mitochondria 2023. 

Mitochondria are only inherited through the oocyte and the metabolic environment is also transmitted through epigenetic mechanism in mammals. 

Dr. Sirard and his team have evidence that  DNA methylation  in the mitochondrial and genomic DNA might play a role in the  programming of gene expression in the next generation. Genomic studies  indicate a gene regulation  impact of the mitochondrial genome  associated methylation levels using the bovine oocyte-embryo model.

Dr. Sirard's talk will be titled "The Power of Epigenetics: The Patterns of mitoDNA Methylation Transmitted Across Generation".

You can learn more about this topic and benefit from the experience of Dr. Sirard by joining Targeting Mitochondria 2023.

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

Targeting MCJ/DnaJC15 to modulate mitochondrial respiration in disease

Mercedes RinconDr. Mercedes Rincon, University of Colorado Anschutz School of Medicine, USA will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Targeting MCJ/DnaJC15 to modulate mitochondrial respiration in disease".

Dr. Rincon and her team have identified MCJ (also called DnaJC15) as a novel negative regulator of mitochondrial metabolism. MCJ associates with Complex I of the ETC, and acts as a negative regulator of Complex I and mitochondrial respiration. MCJ deficiency results in increased mitochondrial respiration, but it has no effect on glycolysis and does not increase the production of reactive oxygen species (ROS). 

Dr. Rincon will present their studies showing that MCJ is emerging as a target for non-alcoholic fatty liver disease (NAFLD), and how silencing of MCJ in hepatocytes can be a safe therapeutic strategy for treatment of this and other mitochondria-mediated liver diseases. She will also describe how loss of MCJ in cancer cells leads to chemotherapy resistance due to increased mitochondrial respiration and how MCJ mimetics can overcome chemoresistance.

Join Targeting Mitochondria 2023 to learn more about Dr. Rincon's exciting talk. You can submit a related abstract here.

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

Repairing Marginal Kidneys With Mitochondrial Transplantation: A New Powerful Tissue Engineering Tool That Will Change the Transplant Landscape

Dr. OrlandoDr. Giuseppe Orlando, Wake Forest University, USA, will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Repairing Marginal Kidneys With Mitochondrial Transplantation: A New Powerful Tissue Engineering Tool That Will Change the Transplant Landscape".

The lecture will illustrate the state of the art of kidney transplantation and the role that mitochondrial transplantation will have in increasing the donor pool. 

It is predicted that mitochondrial medicine will dramatically increase the number of transplantable organs by offering a valuable technology that will enable transplantation to repair marginal allografts. The organ preservation and repair platform should therefore be seen by the mitochondrial society as a formidable platform offered by transplant medicine for the application of mitochondria-based technologies

Join Targeting Mitochondria 2023 to learn more about Dr. Orlando's exciting talk. Read more about Dr. Orlando's latest promising findings.

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

Mitochondria Organelle Transplantation for Neurological Diseases & Aging

Mark S. KindyDr. Mark S. Kindy from the University of South Florida, USA, will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Mitochondria Organelle Transplantation for Neurological Diseases and Aging".

Join Targeting Mitochondria 2023 to learn more about Dr. Kindy's exciting talk.  

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

What spaceflight and bed rest have in common: A proteomic point of view

Marta MurgiaDr. Marta Murgia from the University of Padova, Italy will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "What spaceflight and bed rest have in common: A proteomic point of view".

In the absence of mechanical loading, skeletal muscle undergoes atrophy with loss of strength and detrimental metabolic effects. Dr. Murgia and her team used highly sensitive mass spectrometry (MS)-based proteomics to detail single fiber type-specific molecular remodeling caused by muscle unloading, using bed rest as a model.

In parallel, they measured the muscle proteome of two astronauts, from biopsies taken before and after a six months mission on the International Space Station (ISS). In their muscle lysates, they measured a sharp decrease in the expression of the whole mitochondrial proteome.

Dr. Murgia's talk will give an overview of the main proteomic changes that we measured in these two different models of muscle unloading and disuse. She will highlight striking similarities as well as profound differences. She will discuss the protective role of exercise on skeletal muscle mass in space, with a focus on the mitochondrial proteome.

Join Targeting Mitochondria 2023 to learn more about Dr. Murgia's exciting talk. You can submit a related abstract here.

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

Advances in the Development of Mitochondria-Targeted Pharmaceuticals

Maxim SkulachevDr. Maxim Skulachev, CSO at Mitotech (Israel) , who manages Mitotech's core scientific research,  will share the latest advances in developing  mitochondria targeting drugs during Targeting Mitochondria 2023 this October.

In the last 15 years of his life and scientific career, Vladimir Skulachev dedicated himself to his project on practical application of penetrating ions. This ambitious endeavor focuses on developing new pharmaceuticals based on mitochondria-targeted antioxidants of the SkQ class.

Mitotech's leading compound, SkQ1, is currently undergoing extensive development for different indications and in various pharmaceutical forms, including eye drop formulations (which have reached the third stage of clinical trials in the US), as well as oral and injectable "systemic" formulations.

In this presentation, Dr. Skulachev would like to share their recent findings from preclinical studies they completed using the latter formulations, Mitotech team successfully harnessed both the antioxidant and mild uncoupling properties of SkQ1 molecule.

Dr. Skulachev's short talk will be titled:  "Advances in the Development of Mitochondria-Targeted Pharmaceuticals".

Read more about Professor Vladimir Skulachev's impact.

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

Vladimir Skulachev's Strategic Impact on Mitochondrial Medicine: A Tribute to his Vision, Discoveries, and Legacy

Dr. Vladimir GogvadzeProf. Vladimir Gogvadze, Karolinska Institutet, Sweden, and active member of the scientific committe will join Targeting Mitochondria 2023 this October and introduce the congress.

Prof. Gogvadze will dedicate his talk to Prof. Vladimir Skulachev, former member of the scientific committee of WMS, to recognize his impact in the Mitochondria World: "Vladimir Skulachev's Strategic Impact on Mitochondrial Medicine: A Tribute to his Vision, Discoveries, and Legacy".

Read more about Professor Skulachev's impact.

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

Metabolic effects of Cimicfuga racemosa extract on mitochondria and implications for the resistance against oxidative cell death and longevity

Dr. Carsten CulmseeProf. Carsten Culmsee, active member of the scientific committe and from the University of Marburg, Germany, will join Targeting Mitochondria 2023 this October. He will have a talk entitled "Metabolic effects of Cimicfuga racemosa extract on mitochondria and implications for the resistance against oxidative cell death and longevity".

Cimicifuga racemosa extract (CRE) is a well-established herbal medication to treat menopausal symptoms such as hot flashes and weight gain. In contrast to estrogen replacement therapy or phytoestrogens, however, CRE does not act through stimulation of estrogen receptors but through metabolic mechanisms. Prof. Culmsee and his team's findings suggest that CRE Ze 450 rather exerts direct effects on mitochondrial energy turnover through interference with components of the mitochondrial electron transport chain (ETC). 

Prof. Culmsee will provide a comprehensive insight into the signalling effects of the extract on the mitochondrial proteome and metabolome, highlighting the role of CREe for the resilience against age-related processes engaging impaired mitochondria and loss of antioxidative capacities.

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

Mitochondria in the Press & Media

 

News archive