Targeting Mitochondria 2023 will be held on October 25-27

KW52 05 BerlinerDom DL PPT 1

The scientific committee is pleased to announce the organization of the 14th World Congress on Targeting Mitochondria on October 25-27, 2023 in Berlin, Germany. 

We will keep you updated concerning the venue of the meeting, speakers, program and registration.

The committee is open to any topic suggestion. If you wish to suggest any proposition, please send us an email on mitochondria[at]targeting-mitochondria.com.


Targeting Mitochondria 2023 Congress
October 25-27, 2023 - Berlin, Germany 
wms-site.com

 

Targeting Mitochondria 2022 Best Innovation Award

John BallJohn Ball, National Eye Institute (NEI), The National Institutes of Health (USA) was discerned the best scientific award for his innovative work on Mitochondria in Retinal Photoreceptors: More than Meets the Eye.

"The finding that mitochondria in retinal photoreceptors have a prominent optical role provides a promising avenue to connect photoreceptor bioenergetics with noninvasive retinal imaging. To this end, we are currently developing our electromagnetic simulations to capture the influence of photoreceptor mitochondria on clinical imaging, and we plan to examine the connections between mitochondrial function and their optical characteristics."

Targeting Mitochondria 2022 Best Poster Presentation Awards

Mitochondria-2020-congress-vanner


Daniel Szames - Poster award 2022Poster Presentation Award #1

Daniel Szames, University of Toronto, Canada was discerned the best poster presentation award for his poster on Peptide Mediated Mitochondrial Delivery of Temozolomide for Evading Cellular Resistance Mechanism.

"Future work involving mitochondria-targeted temozolomide include further exploring the therapeutic potential as well as exploring its use as a DNA-damage repair probe. The use of patient-derived glioblastoma stem cells will act as a relevant model to determine whether mitochondria-targeted temozolomide has clinical potential. This compound can also be used to investigate the role of other DNA-damage repair mechanisms in mitochondria; for example, to investigate the role of mismatch repair in mitochondria."


Sophie Dhorne-Pollet Poster award 2022Poster Presentation Award #2

Sophie Dhorne-Pollet, Université Paris-Saclay , INRAE, France was discerned the best poster presentation award for her poster on Mitochondrial Genomes Long Read Sequencing Methodology Applied to Multispecies for the Identification of Genetic Variants.

 


Mina Lim Poster Award 2022Poster Presentation Award #3

Mina Lim, CHA University 차의과학대학교, Republic of Korea, was discerned the best poster presentation award for her poster on Mitochondria Enriched NK Cell Therapy for Solid Tumors.

Targeting Mitochondria 2022 Best Short Oral Presentation Award

Mercedes Fernandez-Moreno short oral presentation winner wms 2022Mercedes Fernandez-Moreno, Instituto de Investigación Biomédica de A Coruña (INIBIC), Spain, was discerned the best short oral presentation award for her innovative talk on the Approach for Using Intra-Articular Injection of Mitochondria to Treat Osteoarthritis.

"Nowadays there is not cure or an efficient treatment for osteoarthritis (OA), despite of its the most common rheumatology illness and a major cause of pain and disability in older adults. The relation between mitochondria alteration and OA was described in several studies in which the authors explained how mitochondrial alteration can modulate the chondrocyte function and its survival during this pathogenesis

Mitochondria have proposed as a potential therapeutic target for OA. We hypothesized that transplantation of heterologous mitochondria from healthy donor would ameliorate the OA effects. The analysis of in vivo model showed that mitochondria injection was safety and no inflammatory response was observed in the joint. These preliminary data give us the possibility to continue studying the mitochondrial transplantation as an efficient treatment for OA.

Taken into account our preliminary data, we will continue in the develop of more robust data generating a complete in vivo model to confirm the role of healthy mitochondria over the OA cartilage."

 

 

Targeting Mitochondria 2022 Best Scientific Award

Ian HoltIan J. Holt, Instituto de Investigación Sanitaria Biodonostia (Spain) was discerned the best scientific award for his brilliant work on 2-Deoxy-D-Glucose Couples Mitochondrial DNA Replication with Mitochondrial Fitness.

"Continuing the collaboration with Professor Spinazzola (University College London), we have developed comprehensive future plans, which have attracted new funding. Briefly, we plan to: 

i) launch the first clinical trial of 2DG late in 2023 in patients carrying the m.3243A>G mutation; 

ii) test 2DG against other heteroplasmic variants, including in a heteroplasmic mouse model (m.5024C>T); 

iii) assess the effect of the compound on other cell types; and finally

iv) elucidate further how nutrient and metabolite availability affect mitochondrial DNA replication and selection. 

These are exciting times for us and we hope to be able to share our substantial progress with you next year."

 

 

Targeting Mitochondria 2022 Online Posters

Conference-online-posters

Please find here all Online posters presented during the Targeting Mitochondria 2022 Congress. The abstract of each poster is included in Abstracts Book of congress.

ONLINE POSTERS
ADISA, Rahmat Adetutu MITOQUINOL MESYLATE (MITO-MES) TARGETS MITOCHONDRIAL ANTIOXIDANT AND RESPIRATORY ENZYMES IN CIRRHOTIC AND HEPATOCELLULAR CARCINOGENIC RATS
BOGRAYA, Maria MICRORNAS CAUSE DYSFUNCTIONAL PROCESSES IN MITOCHONDRIA IN NAFLD
GHOSH, Ilora GLUTAMINE DEPRIVATION INDUCED SENSITIZATION OF CANCER CELL INHIBITION BY LOW-DOSE MITOCHONDRIAL ETC COMPLEX I INHIBITOR: A LABEL-FREE QUANTIFICATION APPROACH TO STUDY ALTERATION IN MITOCHONDRIAL PROTEOME
LUDWIG-SŁOMCZYŃSKA, Agnieszka H. CYTOSOLIC DNA SENSING AND MITOCHONDRIAL TRANSCRIPTOMIC CHANGES AS EARLY TRIGGERS OF METABOLIC DISEASE IN DB/DB MICE
MACUADA, Josefa MITOCHONDRIAL NUCLEOID DISTRIBUTION IS PERTUBED BY OPA1 ADOA-CAUSING MUTANTS
PARKER, Haleigh EPITHELIAL TO MESENCHYMAL TRANSITION CONFERS SENSITIVITY TO CYTOTOXIC AGENT OPHIOBOLIN A VIA ALTERATIONS IN MITOCHONDRIAL FUNCTION AND METABOLIC PATHWAYS
PECINA, Petr UNCOVERING THE OXPHOS COMPLEXES' INTERDEPENDENCE
VAN POLANEN, Nynke MITOCHONDRIAL COMPENSATION IN PATIENTS WITH M.4300A>G MUTATION
VAN RENSBURG, Daniel Jacobus THE BIO-BEHAVIOURAL PROFILE OF THE NDUFS4 MOUSE AS A PLATFORM FOR NEUROPSYCHIATIC RESEARCH INTO MOOD DISORDERS

 

Did you participate in Targeting Mitochondria 2022?

The all presented major & short oral communications will be available as recorded presentations shortly.

Did not attend but wish to access to the Replay :

To access to the Congress & Workshop recorded presentations and get the Abstracts Book of congress & workshop, please contact us.

Best Mitochondria Image Contest 2022

Best Mitochondria Image Contest 2022

Submit a memorable Mitochondria Image you’ve taken this past year and get the chance to win a free registration for the next congress to be held in 2023! The scientific committee also accept artwork and drawings related to Mitochondria (life, death, energy, dynamics and philosophy...). 

Entries must be original and contestants should be registered to the Targeting Mitochondria 2022 congress. Results will be announced during the 13th WMS Annual meeting this October.

Image Submission Guidelines

To enter the contest, please make sure to send us the following information on a Word Document:

1. Your name

2. Your complete affiliation

3. A picture of you (optional)

4. Your Mitochondria Image with:

- A title

- The description of the image

- The context of the study

 

and send it to: This email address is being protected from spambots. You need JavaScript enabled to view it.

 May the best image Win!

 

Prof. Wallace: Keynote Speaker at WMS 2022

Mitochondria 2022 Mitochondrial Medicine present and future

It was a great pleasure to welcome Prof. Douglas C. Wallace, Children's Hospital of Philadelphia, USA, at Targeting Mitochondria 2022 congress. He  introduced the meeting with a keynote speech on Mitochondrial Medicine : Present and Future.

Read more...

Recent Advances in Mitochondrial Transplantation Therapy

Dr James McCullyDr. James D. McCully, from The Harvard Medical School Department of Cardiac Surgery Boston Children’s Hospital, USA, will join us this year to present his most recent findings on "Recent Advances in Mitochondrial Transplantation Therapy".

Join us in Targeting Mitochondria 2022 and benefit from the experience of professional researchers in this field. Book your spot.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 
wms-site.com

 

 

 

Regulation of Mitochondrial DNA Polymerase POLG1 Proteolysis and its Role in the Progeroid Disease Cockayne Syndrome and Physiological Ageing

Miria RicchettiDr. Miria Ricchetti, Institut Pasteur, France will join us this year to present her most recent findings on "Regulation of Mitochondrial DNA Polymerase POLG1 Proteolysis and its Role in the Progeroid Disease Cockayne Syndrome and Physiological Ageing".

The mechanisms of proteolysis and proteostasis of several mitochondrial matrix proteins are known. This was not the case for the pivotal polymerase POLG1 that ensures the replication of the mitochondrial genome. Dr. Ricchetti and her team show here a mechanism that leads to POLG1 degradation and has implications in pathophysiological ageing.

Join us in Targeting Mitochondria 2022 and benefit from the experience of professional researchers like Dr. Ricchetti. Book your spot.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 

Targeting the Mitochondrial Unfolded Protein Response in Prostate Cancer

Dhyan ChandraDr. Dhyan Chandra, Roswell Park Comprehensive Cancer Center, USA will join us this year to present his most recent findings on "Targeting the Mitochondrial Unfolded Protein Response in Prostate Cancer".

Dr. Dhyan Chandra has identified the mitochondrial unfolded protein response (UPRmt) as a new target for prostate cancer treatment and management. His research team revealed that the two key components of the UPRmt, heat shock protein 60 (HSP60, a mitochondrial chaperonin) and caseinolytic protease (ClpP, a mitochondrial protease) work together and are required for the development of advanced prostate cancer. They observed that HSP60 acts as upstream regulator of ClpP expression and HSP60 interacts with ClpP to maintain mitochondrial function.

Dr. Chandra has also discovered a novel UPRmt (referred to as DCEM1) that inhibits HSP60 interactions with ClpP in prostate cancer cells and prostate tumors, leading to the blockade prostate cancer growth and progression in preclinical study. Since the current androgen deprivation and taxane-based therapy are not effective, these findings provide alternative treatment approaches for prostate cancer that do not rely on androgen receptor signaling axis.      

Join us in Targeting Mitochondria 2022 and benefit from the experience of professional researchers like Dr. Chandra. Book your spot.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 

Mitochondrial DNA as Extracellular Vesicle Cargo in Aging and Age-related Conditions

Mitochondria 2022 speakers-Nicole Noren Hooten

Dr. Nicole Noren Hooten from the National Institute on Aging, National Institutes of Health, USA will join us this year to present her recent findings on “Mitochondrial DNA as Extracellular Vesicle Cargo in Aging and Age-related Conditions” in a session entitled “Extracellular Vesicles & Mitochondria: The Target”

Mitochondrial DNA (mtDNA) can be released into the extracellular space as circulating cell-free mitochondria DNA (ccf-mtDNA). Recent findings from our laboratory indicate that ccf-mtDNA in plasma can be encapsulated in extracellular vesicles (EVs). EVs are small nano-sized particles that are released by cells into the circulation and shuttle bioactive cargo as part of intercellular communication systems.

Dr. Noren Hooten's talk will discuss the role of mitochondrial DNA in extracellular vesicles in the context of aging and age-related conditions.

Join us in Targeting Mitochondria 2022 and benefit from the experience of professional researchers like Dr. Noren Hooten. Remember that you too can present your most recent findings related to this session by submitting your abstract.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 
wms-site.com

The Impact of Mesenchymal Stromal Cell Extracellular Vesicles on Mitochondrial Dysfunction in Acute Respiratory Distress Syndrome

Mitochondria 2022 Dr. Anna KrasnodembskayaDr. Anna Krasnodembskaya from Queen's University Belfast, The United Kingdom,  will join us this year to present her most recent findings on "The Impact of Mesenchymal Stromal Cell Extracellular Vesicles on Mitochondrial Dysfunction in Acute Respiratory Distress Syndrome" in a session entitled "Extracellular Vesicles & Mitochondria: The Target".

Join us in Targeting Mitochondria 2022 and benefit from the experience of professional researchers like Dr. Krasnodembskaya. Remember that you too can present your most recent findings related to this session by submitting your abstract.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 
wms-site.com

Autologous Mitochondrial Transplant for Cerebral Ischemia

Mitochondria 2022 Dr. Melanie WalkerDr. Melanie Walker from the University of Washington Medical School, USA,  will join us this year to present her most recent findings on "Autologous Mitochondrial Transplant for Cerebral Ischemia".

Stroke is one of the leading causes of morbidity and mortality worldwide. More than 80% of strokes are the result of ischemia caused by blockage of one or more cerebral arteries. Lack of blood supply starves brain cells of necessary glucose and oxygen, and disturbs cellular homeostasis, eventually resulting in neuronal death. Based on many preclinical studies in animals, damage caused by ischemia can be reversed after infusing healthy mitochondria into injured tissues. An ongoing clinical trial in human hearts at Boston Children's Hospital has also demonstrated that transplanting autologous mitochondria via infusion or direct injection is well-tolerated and safe.

Dr. Walker and her clinical research team are currently recruiting for a first-in-human-brain trial to assess the safety of mitochondrial transplantation for ischemic-reperfusion injury in the brain. She will discuss their preclinical studies and status of their clinical trial.

Join us in Targeting Mitochondria 2022 and benefit from the experience of professional researchers like Dr. Walker. Book your spot.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 
wms-site.com

Mitochondrial and Photo-Medicine - Recent Clinical Applications

Mitochondria 2022 speaker - Michael WeberDr. med. Michael Weber, President of European Laser Academy, Germany will join us this year to present his most recent findings on "Mitochondrial and Photo-Medicine - Recent Clinical Applications".

Join us in Targeting Mitochondria 2022 and benefit from the experience of professional researchers like Dr. WeberBook your spot.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 
wms-site.com