Mitochondrial Dynamics: Updates and Perspectives
It is a great pleasure to welcome Dr. Ježek Petr, Institute of Physiology of the Czech Academy of Sciences, Czech Republic, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondrial Dynamics: Updates and Perspectives.
Highlights
- Mitochondrial network facilitates rejuvenation of fragments and communication via exosomes.
- Mitochondrial cristae morphology changes with metabolism and oxidative phosphorylation (OXPHOS).
- INS-1EΔe+g cells showed lower ATP synthesis, inhibited insulin secretion (IS), and distinct mitochondrial cristae structures.
- Exosomes from stressed pancreatic cells may communicate stress responses.
- Regular mitochondrial cristae can form without major FO subunits of ATP-synthase.
- Delayed mitophagy in IS-impaired cells might lead to exosomes signaling pathology.
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Annual World Congress on Targeting Mitochondria
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Role of Light in Regulating Blood Glucose via Mitochondrial Stimulation
It is a great pleasure to welcome Dr. Michael B. Powner, City University of London, United Kingdom, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Role of Light in Regulating Blood Glucose via Mitochondrial Stimulation.
About Michael B. Powner
Dr. Michael Powner is a Senior lecturer in Neurobiology, joining the Optometry division at City, University of London in February 2016. Dr. Powner is a neurobiologist who explores the mechanisms behind cellular stress during the early stages of retinal diseases; including age related macular degeneration (AMD) and diabetic retinopathy. He is also passionate about developing or adapting non invasive interventions, including optical and electrical stimulation, to improve patients health and quality of life.
In collaboration with Prof. Jeffery at UCL Institute of Ophthalmology, he is investigating the potential of red light (670nm) as a therapy for aging and ocular diseases, including age related macular degeneration.
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Annual World Congress on Targeting Mitochondria
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Investigating Mitochondria as Age-Old Drivers of Inflammation
It is a great pleasure to welcome Dr. Stephen Tait, University of Glasgow, United Kingdom, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Investigating Mitochondria as Age-Old Drivers of Inflammation.
Stephen Tait's Research Interest
Cell death is a key tumour suppressor mechanism that must be inhibited in order for cancer to develop. Sensitivity to cell death also governs therapeutic efficacy because anti-cancer therapies often act by killing cells. The major form of programmed cell death is apoptosis, a process in which mitochondria play an essential role.
His research focuses upon understanding how mitochondria control cell death and addressing how this is deregulated in cancer. Clinical translation of our findings should lead to improvements of existing therapies and development of new approaches to enable tumour selective killing.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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Targeting Giant Mitochondria (Megamitochondria) in Human Liver Disease: Potential Diagnostic and Therapeutic Interventions
It is a great pleasure to welcome Dr. Elena Palma, King's College London, United Kingdom, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Targeting Giant Mitochondria (Megamitochondria) in Human Liver Disease: Potential Diagnostic and Therapeutic Interventions.
Key Points
- Megamitochondria are disproportionately enlarged organelles with regular paracrystalline inclusions.
- Their significance and how they form are still under debate.
- Their detection has strikingly been linked to improved survival among patients with Alcohol-related liver disease.
- New models are needed to investigate this intriguing phenomenon and human precision cut liver slices represent a crucial advance for this purpose.
About Elena Palma
One of Dr. Palma's interests is developing ex vivo experimental models to study liver diseases and malignancies, using dynamic cultures of human precision-cut tissue slices.
Her research investigates the role of mitochondria in the pathogenesis and progression of Alcohol-related liver diseases with the final aim to target these organelles for therapeutic purposes.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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Evaluation and Quality Control of Mitochondrial Function: Where we are Now & What's Next?
It is a great pleasure to welcome Dr. Egbert Mik, Erasmus MC, The Netherlands, and active member of the WMS scientific committee, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Evaluation and Quality Control of Mitochondrial Function: Where we are Now & What's Next?
About Egbert Mik
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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The Power and Potential of Mitochondria Transfer
Dr. Jonathan R. Brestoff, Washington University in St. Louis School of Medicine, USA, will join the 15th WMS Annual Congress on Targeting Mitochondria 2024.
Dr. Brestoff will present his latest research on The Power and Potential of Mitochondria Transfer.
Join Targeting Mitochondria 2024 to learn more about the latest advances in mitochondrial transfer.
About Jonathan R. Brestoff
Jonathan R. Brestoff, M.D., Ph.D., M.P.H., is an assistant professor of pathology and immunology at Washington University School of Medicine (WUSM). He completed his M.D./Ph.D. at the Perelman School of Medicine at the University of Pennsylvania with Dr. David Artis, where Dr. Brestoff’s work identified that group 2 innate lymphoid cells induce beige fat to limit the development of obesity. He then moved to WUSM in 2016 for his residency in pathology, during which time Dr. Brestoff completed his postdoctoral training with Dr. Steven Teitelbaum. For his research on a process called intercellular mitochondria transfer, Dr. Brestoff was awarded the NIH Director’s Early Independence Award and Burroughs Wellcome Fund Career Award for Medical Scientists, allowing him to launch his independent laboratory at WUSM in 2019. His lab continues to study immunometabolism and intercellular mitochondria transfer, leading to his lab’s pioneering studies on mitochondria transfer from adipocytes to macrophages, which was named in Cell Metabolism’s Best of 2021 special issue. His work on these subjects has been published in Nature, Cell, Science, Cell Metabolism, Nature Immunology, Nature Metabolism, and other top journals. He is a member of the scientific advisory board for LUCA Science, Inc., based in Tokyo, and is a trustee at his alma mater, Skidmore College.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
October 28-30, 2024 - Berlin, Germany
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Dr. James McCully will be invited by Dr. Marvin Edeas to highlight Mitochondrial Transplantation on March 22
Dr. Marvin Edeas, Institut Cochin, INSERM U1016, Université Paris Cité, France, is pleased to invite Dr. James McCully of Harvard Medical School and Boston Children's Hospital to present a talk dedicated to Mitochondrial Transplantation, both online and in Paris.
The focus of the Dr. McCully's talk will be on "Mitochondrial Transplantation: Rescue of Cellular Viability and Function and Modulation of the Ischemic Phenotype in the Myocardium".
Dr. McCully will discuss the role of mitochondrial transplantation in improving outcomes for myocardial ischemia/reperfusion injury and its effects on the transcriptomic profile.
You are all cordially invited to join us.
World Mitochondria Society
Practical Information
Date & Venue
The webinar is scheduled for Friday, March 22, 2024, from 3:00 PM to 5:15 PM Paris time.
Participants can choose to attend the event in two ways:
- In person at the Université Paris Cité, Institut Cochin - Bâtiment Méchain, Salle Rosalind Franklin, in Paris.
- Virtually, through a Zoom webinar.
Registration & Participation
There is no fee to attend this webinar, but space is limited. Interested individuals are encouraged to register early to ensure participation.
Why did Dr. Marvin Edeas invite Dr. James McCully to host a webinar on Mitochondrial Transplantation?
Dr. McCully plays a strategic role in the field of medicine, especially his groundbreaking work in pediatric cardiac surgery and his development of mitochondrial transplantation. Dr. McCully has dedicated his career to innovating treatment approaches for congenital heart conditions, significantly improving outcomes for pediatric patients. His research has not only advanced surgical procedures but also introduced new technologies to enhance the quality of life for children with heart defects.
The technique of mitochondrial transplantation, pioneered by Dr. McCully, represents a major advancement in medical science, offering a novel method to deliver healthy mitochondria directly to damaged tissues, thus rescuing organ function. This innovation, first applied at Boston Children's Hospital in 2014, has shown that mitochondrial transplantation can safely and effectively restore injured heart muscle, even in critical cases.
Given Dr. McCully's extensive publication record, with 234 papers and 13 patents, and his involvement in leading scientific associations, his expertise and contributions are highly valued by the medical community. His work aligns closely with the interests of the World Mitochondria Society, making him an ideal candidate to share insights on the therapeutic efficacy of mitochondrial transplantation in treating myocardial ischemia/reperfusion injury and its potential for broader applications in medicine.
DOI Assignment for Targeting Mitochondria 2024 Abstracts
We are pleased to announce that all abstracts submitted this year to the 15th Annual meeting of the WMS will be included in the Targeting Mitochondria 2024 Abstracts Book, which will be assigned a DOI (Digital Object Identifier). This ensures your work will have a permanent and easily accessible online presence.
Importance of DOI
Having a DOI means your abstracts will be indexed on major academic platforms such as ORCID, Google Scholar, Scopus and others. This not only enhances the visibility of your research but also facilitates easy citation and sharing within the scientific community.
Abstract Submission Details
You can submit your abstracts here: www.wms-site.com/abstract submission.
Emerging Trends & Strategies: 15th World Congress 2024
Join us in Berlin from October 29-31, 2024, for the 15th World Congress on Targeting Mitochondria.
Targeting Mitochondria 2024: New Visionary Approaches
The President of the World Mitochondria Society, Volkmar Weissig, and the Chairman of the Scientific Board, Marvin Edeas, have highlighted the complexities involved in curating an agenda and identifying suitable speakers as significant challenges. In response, they are adopting a progressive and "out of the box" perspective.
Volkmar Weissig and Marvin Edeas aim to take an unconventional approach by concentrating on Emerging Trends and Strategies in mitochondrial research. To this end, they have selected topics such as exosomes and extracellular vesicles, the application of artificial intelligence, the mitochondria-microbiota interplay, the role of mitochondria in photomedicine, and exploratory discussions on the incorporation of Chinese medicine principles.
Summary of the Agenda
Day 1 - Tuesday, October 29, 2024: Mitochondria Workshop
- Workshop Title: “How to Evaluate Mitochondria Function? Bridging Theory and Practice”
- Led by: Dr. Naïg Gueguen, MitoVasc Institute, Angers University Hospital Center, France.
- Focus on methodologies and techniques for assessing mitochondrial function accurately.
Day 2 - Wednesday, October 30, 2024: Keynote and Sessions
Keynote Presentation: “The Mitochondrial Kingdom: Historical Moments, Evolutionary Insights, Current Understanding, and Future Projections.”
Session 1: Mitochondrial Biodynamics in Health and Diseases
- Topics include mitochondrial mitophagy and biogenesis, mitochondria in cancer, aging, cell communication, and the interconnections between iron, ferritin, and mitochondria.
Session 2: Evaluation and Quality Control of Mitochondrial Function
- Highlights innovations in mitochondrial function measurement, real-time visualization techniques, new monitoring devices, and quality control mechanisms.
Day 3 - Thursday, October 31, 2024: Continuing Sessions and Concluding Remarks
Session 3: 15th World Mitochondria Society Meeting on Emerging Trends and Strategies
- Covers exosomes and extracellular vesicles, AI in research, mitochondria-microbiota interplay, updates on mitochondria in photomedicine, and considerations of Chinese medicine.
Session 4: Mitochondrial Medicine 2024: From Bench to Bedside
- Focuses on practical applications like mitochondrial transplantation, transfer & tunneling nanotubes, pharmaceutical approaches, and the latest clinical studies targeting mitochondria.
Concluding Remarks & Awards:
- Summarizing key takeaways, next steps in mitochondrial research, and recognizing outstanding contributions.
It will be a great pleasure to meet you in Berlin next October for this exciting congress!
Sincerely,
Prof. Volkmar Weissig
President of the World Mitochondria Society
Midwestern University, USA
On behalf of the WMS Scientific Board
2023 Best Scientific Contribution Award at Targeting Mitochondria 2023
Dr. Naig Gueguen from the Mitovasc Institute has been recognized with the coveted 2023 Best Scientific Contribution Award, a testament to her role as a trailblazing scientist in the field.
In her excellent workshop titled "How to Evaluate Mitochondrial Function," Dr. Gueguen, affiliated with INSERM 1083, CNRS 6215, and Centre Hospitalier Universitaire d’Angers, showcased the depth of her expertise.
She navigated through the nuances of mitochondrial study, touched on key technological tools, delved into critical markers, elucidated diverse techniques for examination, presented diagnostic approaches, and shared invaluable case studies centered on mitochondrial anomalies.
The WMS extends its heartfelt congratulations to Dr. Gueguen for her stellar contributions and presentation.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
wms-site.com
2023 Best Short Oral Presentation Award
Targeting Mitochondria 2023 Best Short Oral Presentation Award #2
The World Mitochondria Society celebrates Sami Noujaim from the University of South Florida, USA, for clinching the Targeting Mitochondria 2023 Best Short Oral Presentation Award.
Dr. Noujaim's insightful talk, "Mitochondrial Involvement in Cardiac Electrophysiological Injury Due to Inhalation Exposure to Electronic Nicotine Delivery Systems (ENDS)," delved into the alarming effects of vaping on heart electrophysiology.
He expertly highlighted the role of adverse mitochondrial changes and increased oxidative stress in these effects.
All our congratulations.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
wms-site.com
2023 Best Short Oral Presentation Award
Targeting Mitochondria 2023 Best Short Oral Presentation Award #1
The World Mitochondria Society congratulate Dr. Ioannis Tsichlis from the National & Kapodistrian University of Athens, Greece, for earning the Best Short Oral Presentation award at Targeting Mitochondria 2023.
Dr. Tsichlis's profound talk, titled "Development of Mitochondria-Inspired Lipopolyplexes for Gene Delivery," was a deep dive into the cutting-edge realm of gene therapy.
He presented a novel mitochondrial-inspired nanosystem, which incorporated the properties of mitochondria into hybrid lipopolyplexes. These meticulously crafted structures are geared towards efficient gene delivery, offering a potential leap in therapeutic interventions. Particularly noteworthy was their remarkable stability across various media, an essential characteristic for real-world applications.
His talk was a testament to his dedication and innovative approach in the field of targeting mitochondria.
Dr. Tsichlis shared with the World Mitochondria Society: "Following the successful development of mitochondria-inspired lipopolyplexes, our research involves in vitro cytotoxicity studies and in vivo biological experiments in the well-established C. elegans model to evaluate the specificity and efficiency of the nanoplatform in targeting mitochondria. The ultimate goal is to develop a safe and effective bio-inspired gene delivery nanoplatform that will contribute to mitochondrial gene therapy."
All our congratulations.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
wms-site.com
Targeting Mitochondria 2023 Best Poster Presentation Award for Young Investigator
It gives us immense pleasure to announce that Tatjana Kuen from Leopold-Franzens Universität Innsbruck, Austria, has been distinguished with the Targeting Mitochondria 2023 Best Poster Presentation Award for Young Investigators.
Her poster, titled "Inhibitors of Fumarylacetoacetate Domain Containing Protein 1 (FAHD1) Induce Premature Cellular Senescence in Human Endothelial Fibroblasts in Vitro," delves into the intricate role of FAHD1 as an oxaloacetate decarboxylase in the TCA cycle regulation. Notably, the findings revealed that a lentiviral knockdown of FAHD1 could lead HUVEC cells into premature cellular senescence. The proposed model suggests a mitochondrial dysfunction-associated senescence-like phenotype that is potentially mediated through the reduction of complex-II activity. Currently, Tatjana and her team are exploring the use of second-generation FAHD1 inhibitors to replicate this intriguing effect.
Join us in extending heartfelt congratulations to Tatjana Kuen for this outstanding achievement.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
wms-site.com
The Power of Epigenetics: The Patterns of mitoDNA Methylation Transmitted Across Generation
Dr. Marc-André Sirard, Director of the Center for Research in Reproduction, Development and Intergenerational Health at Université Laval, Canada , will share his latest findings via a major talk at Targeting Mitochondria 2023.
Mitochondria are only inherited through the oocyte and the metabolic environment is also transmitted through epigenetic mechanism in mammals.
Dr. Sirard and his team have evidence that DNA methylation in the mitochondrial and genomic DNA might play a role in the programming of gene expression in the next generation. Genomic studies indicate a gene regulation impact of the mitochondrial genome associated methylation levels using the bovine oocyte-embryo model.
Dr. Sirard's talk will be titled "The Power of Epigenetics: The Patterns of mitoDNA Methylation Transmitted Across Generation".
You can learn more about this topic and benefit from the experience of Dr. Sirard by joining Targeting Mitochondria 2023.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
Targeting MCJ/DnaJC15 to modulate mitochondrial respiration in disease
Dr. Mercedes Rincon, University of Colorado Anschutz School of Medicine, USA will join the Targeting Mitochondria 2023 Congress and give a presentation entitled "Targeting MCJ/DnaJC15 to modulate mitochondrial respiration in disease".
Dr. Rincon and her team have identified MCJ (also called DnaJC15) as a novel negative regulator of mitochondrial metabolism. MCJ associates with Complex I of the ETC, and acts as a negative regulator of Complex I and mitochondrial respiration. MCJ deficiency results in increased mitochondrial respiration, but it has no effect on glycolysis and does not increase the production of reactive oxygen species (ROS).
Dr. Rincon will present their studies showing that MCJ is emerging as a target for non-alcoholic fatty liver disease (NAFLD), and how silencing of MCJ in hepatocytes can be a safe therapeutic strategy for treatment of this and other mitochondria-mediated liver diseases. She will also describe how loss of MCJ in cancer cells leads to chemotherapy resistance due to increased mitochondrial respiration and how MCJ mimetics can overcome chemoresistance.
Join Targeting Mitochondria 2023 to learn more about Dr. Rincon's exciting talk. You can submit a related abstract here.
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
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