Mitochondria in Retinal Photoreceptors: More than Meets the Eye

Mitochondria 2022 John BallDr. John Ball, from National Institutes of Health, USA, will join us this year to present his most recent findings on the "Mitochondria in Retinal Photoreceptors: More than Meets the Eye".

In the mammalian retina, each cone photoreceptor contains a multitude of mitochondria that appose its outer segment, where photons are detected and translated into bioelectrical signals that lead to perception of light.

Dr. Ball shows that—in addition to their customary energetic role—this mitochondrial agglomeration functions as a microlens that enhances the availability of light at the outer segment. This optical role has implications for both vision and for the diagnosis of retinal disease.

Join us in Targeting Mitochondria 2022 to learn about the many major roles of mitochondria and benefit from the experience of professional researchers like Dr. Ball. Book your spot.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 
wms-site.com

The Multiple Facets of the Mitochondria Shaping Protein Opa1 in Adipocytes: From Epigenetic to Tissue Plasticity

Dr Camilla BeanDr. Camilla Bean, from the University of Padova, Italy will join us this year to present her most recent findings on "The Multiple Facets of the Mitochondria Shaping Protein Opa1 in Adipocytes: From Epigenetic to Tissue Plasticity".

She will introduce us to her studies that substantiate the importance of mitochondrial morphology in adipose tissue biology. By a multiomics approach in different genetic models she shows that adipocyte Opa1 regulates adipose tissue expandability and promotes WAT to BAT remodelling via an unexpected axis involving urea cycle stimulation, fumarate accumulation and the Jumanji family histone demethylase Kdm3a.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 
wms-site.com

Call for Abstracts & Innovations

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This call is addressed to all the scientists, academics, and industrials out there!

The Scientific Committee of the World Mitochondria Society &  Targeting Mitochondria Congress are pleased to invite you to present your most recent findings in the mitochondria field-  during the 13th World Mitochondria Society Annual Meeting on October 26-28, 2022 in Berlin, Germany.

Important dates for this international meeting:

  • Deadline for Short Oral Submission: October 9, 2022
  • Deadline for Poster Submission: October 15, 2022

To know more about the abstracts submission process, please click here.
Be careful not to miss the deadlines!

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WSM logoTargeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany 
www.targeting-mitochondria.com

Winners of the Best Mitochondria Image 2021

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The winners of the Best Mitochondria Image 2021 have been chosen.

1st Place Winner - Midnight Mitochondrial Ghost

Midnight Mitochondrial Ghost

Adelheid Weidinger, from the Ludwig Boltzmann Institute for Traumatology, Austria

Midnight Mitochondrial GhostHuman amniotic epithelial cells incubated with Fe-nanoclusters


2nd Place Winner - A Gift

A Gift

Bianka Porubská, from Charles University, Prague

 

A Gift: Sertoli cell transferig MitoTrackerCMXROS (red) mitochondria to immune cell (CD45, green), Nuclei DAPI (blue)

 

 


3rd Place Winner - Mito-Tree

Mito-Tree

Simon Licht-Mayer, from the Institute for Molecular Biotechnology, Austria

 

Mito-Tree: Live image of the mitochondrial network in a Purkinje cell, including the cell body, axon and huge dendritic tree.


You can see all nominated pictures for the Best Mitochondria Image 2021 here.

 


 

Submit a memorable Mitochondria Image you’ve taken this past year and get the chance to win a free registration for the next congress!

Submit your pictures for Best Mitochondria Image 2022.

Best Short Oral Presentation Award 2021

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Out of 23 short oral presentations communicated during Targeting Mitochondria 2021 (held on October 27-29 2021), the scientific committee selected 4 presentations for the Awards of the Best Short Oral Presentation 2021.

Nomination for the Best Short Oral Presentation Award

Novel Cytotoxic Compounds Targeting Mitochondria
Alaa Al Assi
, Université Grenoble Alpes, France

Transplantation of Muscle Stem Cell-Derived Mitochondria Rejuvenates the Bioenergetic Function of Aged Host Muscle
Young Charles Jang, Georgia Institute of Technology, USA

Impact on Mitochondrial Function by Increased Levels of Mitochondrial RNA Polymerase
Inge Kuhl, Université Paris-Saclay, France

Cross Talk of Mitochondrial Calcification and Inflammation in Human Skeletal Muscle Cells: Implications for Calcinosis
Bhargavi
 Duvvuri, University of Washington, USA

 


The Winner of the Best Short Oral Presentation Award

Targeting Mitochondria 2021 Young Jang AwardTransplantation of Muscle Stem Cell-Derived Mitochondria Rejuvenates the Bioenergetic Function of Aged Host Muscle
Young Charles Jang, Georgia Institute of Technology, USA

Young Charles Jang commenting on his vision for next year: "For the upcoming year, we will continue to do research on how transplanted mitochondria establish mitochondrial-nuclear genomic communication and how aging and oxidative stress alter these interactions."

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Interactive Online Congress
www.targeting-mitochondria.com

 

Best Poster Presentation Awards 2021

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19 Posters were presented during Targeting Mitochondria 2021 (held on October 27-29 2021).

 

Nominated Posters for the Awards of the Best Poster Presentation 2021:

Using Polypeptide-Based Nanoconjugates as Mitochondrially-Targeted Drug Delivery Platforms
Camilla Pegoraro, Centro de Investigacion Principe Felipe, Spain

Disease Causing-MFN2 Mutations Alter Mitochondrial Fusion and Fission Dynamics in Mouse Embryonic Fibroblast
Daniel Lagos, Pontificia Universidad Católica de Chile, Chile

The Mitochondrial Network is Altered in Friedreich’s Ataxia Cardiomyopathy
Bojjibabu Chidipi, University of South Florida, United States of America

The Mitochondrial NME6 Protein is Enzymatically Inactive but Interacts with RCC1L (WBSCR16) in the Matrix Space
Bastien Proust, Ruder Boskovic Institute, Croatia

Functional Characterization of Platelet-Derived Mitochondria-Containing Microparticles in Breast Cancer
Vanessa Veilleux, Université de Moncton, Canada

OPA1 Disease-Causing Mutants Alter Mitochondrial Nucleoid Dynamics
Josefa Macuada, Pontificia Universidad Católica de Chile, Chile

 


 

The winners of the Best Poster Presentation Awards - Targeting Mitochondria 2021

Award #1: 

Targeting Mitochondria 2021 Vanessa Veilleux AwardFunctional Characterization of Platelet-Derived Mitochondria-Containing Microparticles in Breast Cancer, Vanessa Veilleux, Université de Moncton, Canada

"Participating at this international conference was a great experience and broaden my knowledge of mitochondrial research. Having the desire and the deep ambition to contribute to the advancement of scientific knowledge, I’m looking forward to the next Targeting Mitochondria"

  Award #2: 

Targeting Mitochondria 2021 Camilla Pegoraro AwardUsing Polypeptide-Based Nanoconjugates as Mitochondrially-Targeted Drug Delivery Platforms, Camilla Pegoraro, Centro de Investigacion Principe Felipe, Spain

“My Ph.D. project aims to develop novel polypeptide-based carriers that permit targeted drug delivery to mitochondria as a novel breast cancer treatment strategy. We successfully developed several cationic polypeptide-based candidate carriers, and our preliminary results have provided robust evidence for specific mitochondrial colocalization. Our next steps involve the conjugation of bioactive agents of interest to our candidate polypeptide-based carriers, their exhaustive characterization, and their therapeutic evaluation in relevant breast cancer models and possibly other indications.”

 Award #3: 

Targeting Mitochondria 2021 Chidipi AwardThe Mitochondrial Network is Altered in Friedreich’s Ataxia Cardiomyopathy, Bojjibabu Chidipi, University of South Florida, United States of America

"I am currently investigating the mechanisms of cardiomyopathy in Friedreich’s ataxia (FA), an autosomal recessive congenital neurodegenerative disease caused by a deficiency in the frataxin protein. Interestingly, most FA patients are diagnosed with left ventricular hypertrophic cardiomyopathy (HCM), and 60% of patients die with HCM. We recently found that the mitochondrial fission protein (DRP1) expression is significantly decreased, reactive oxygen species are increased, and the mitochondrial membrane potential is depolarized in human induced pluripotent stem cell derived cardiomyocytes (hIPSC-CM) from patients with FA-HCM. My future prospects are to explore the mechanistic links between DRP1, mitochondrial dysfunction and HCM in FA."

 


Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Interactive Online Congress
www.targeting-mitochondria.com

Scientific Award of Targeting Mitochondria 2021

Targeting Mitochondria 2021 Alessandro Prigione AwardAt the end of Targeting Mitochondria 2021, the scientific committee awarded Prof. Alessandro Prigione for his presentation about "Patient-Specific Brain Organoids for Modeling Mitochondrial Diseases"

Alessandro Prigione is a tenured Associate Professor of Pediatric Metabolic Medicine at the Department of General Pediatrics, Neonatology and Pediatric Cardiology at Heinrich Heine University (HHU) in Düsseldorf Germany.

The interest of the Prigione group is to develop induced pluripotent stem cells (iPSC)-based approaches for disease modeling and drug discovery of rare incurable neurological and neurodevelopmental disorders affecting mitochondrial metabolism. A specific focus is on Leigh syndrome, which is the most severe mitochondrial disease affecting children. His latest work (Inak et al Nature Communications 2021) employed human neurons and brain organoids from patients with Leigh syndrome to dissect the neuronal-specific disease mechanisms and led to the identification of novel disease targets and interventions.

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Interactive Online Congress
www.targeting-mitochondria.com

Comprehensive Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

Afshin BeheshtiDr. Afshin Beheshti, from the NASA Ames Research Center, Moffett Field, USA will join us this year to present his recent findings on "Comprehensive Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact".

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

 

 

 

Programmable Synthetic Gene Switches for Mitochondrial Gene Modulation

Targeting Mitochondria 2021 Ganesh-Pandian-NamasivayamProf. Ganesh Pandian Namasivayam from Kyoto University, Institute for Advanced Study, Japan, will join the Targeting Mitochondria 2021 congress and will present his research on "Deleting DNA to Treat Mitochondrial Diseases".

According to his latest studies, mutations in mitochondrial DNA (mtDNA) cause mitochondrial diseases characterized by abnormal mitochondrial function. Although eliminating mutated mtDNA has the potential to cure mitochondrial diseases, no chemical-based drugs in clinical trials are capable of selective modulation of mtDNA mutations. In his presentation, Prof. Ganesh discusses the progress and therapeutic prospects of  synthetic gene switches that can be programmed for targeted elimination of mutated mtDNA through sequence-specific adenine alkylation.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

The Mitochondriotropic DecylTPP Group Lowers Mitochondrial OXPHOS Supercomplex Levels and Induces a Glycolytic Switch

Werner KoopmanProf. Werner Koopman, from the Department of Biochemistry, Radboud Institute for Molecular Life Sciences, will join the Targeting Mitochondria 2021 Congress and will present a talk entitled "The Mitochondriotropic DecylTPP Group Lowers Mitochondrial OXPHOS Supercomplex Levels and Induces a Glycolytic Switch".

Prof. Koopman will discuss the bioenergetic effects of mitochondria-targeted Trolox(MitoE10), in comparison with mitochondria-targeted ubiquinone (MitoQ10) and two mitochondria-targeting moieties (decylTPP, TPMP). Incubation with these molecules did not greatly affect cell viability of primary human skin fibroblasts (PHSFs) from healthy individuals and a patient with Leigh Syndrome (LS). Unexpectedly, MitoE10, MitoQ10 and decylTPP reduced the levels and activity of the first oxidative phosphorylation complex (complex I or CI) and of the amount of  CI+CIII-containing OXPHOS super complexes. Functionally, these effects were associated with reduced cellular oxygen consumption rates, increased extracellular acidification rates , a less negative mitochondrial membrane potential (deltaPSI), a decreased mitochondrial size and elevated levels of hydroethidine-oxidizing ROS. Collectively, these results demonstrate that MitoE10, MitoQ10 and decylTPP lower the levels of CI and CI-containing super complexes in PHSFs, leading to mitochondrial dysfunction and glycolytic switch induction.

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.targeting-mitochondria.com

The One-Carbon Pool Controls Mitochondrial Energy Metabolism via Complex I and Iron-Sulfur Clusters

Anna Wredenberg

Dr. Anna Wredenberg, from Max Planck Institute Biology of Ageing–Karolinska Institutet Laboratory, Karolinska Institutet, Sweden will be joining the Targeting Mitochondria 2021 World Congress, and will deliver a speech concerning "The One-Carbon Pool Controls Mitochondrial Energy Metabolism via Complex I and Iron-Sulfur Clusters".

Accoring to her recent studies, Dr. Wredenberg confirms that vital intermediary steps of one-carbon metabolism are localized to mitochondria, but it remains unclear how it connects to mitochondrial function. Additionally,The one-carbon metabolite and methyl group donor S-adenosylmethionine (SAM) is pivotal for energy metabolism. A gradual decline in mitochondrial SAM (mitoSAM) causes hierarchical defects in fly and mouse, comprising loss of mitoSAM-dependent metabolites and impaired assembly of the oxidative phosphorylation system. Complex I stability and iron-sulfur cluster biosynthesis are directly controlled by mitoSAM levels, while other protein targets are predominantly methylated outside of the organelle before import.

However, the mitoSAM pool follows its cytosolic production, establishing mitochondria as responsive receivers of one-carbon units.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Dysregulation of Mitochondria-Lysosome Contacts by GBA1 Dysfunction in Dopaminergic Neuronal Models of Parkinson’s Disease

Dimitri-Krainc

Dr. Dimitri Krainc, from the Northwestern University Feinberg School of Medicine, Chicago in USA will be will be joining the Targeting Mitochondria 2021 Congress and will demonstrate his study regarding the "Dysregulation of Mitochondria-Lysosome Contacts by GBA1 Dysfunction in Dopaminergic Neuronal Models of Parkinson’s Disease".

Dr. Krainc confirms that he recently identified the formation of direct mitochondria-lysosome membrane contacts that mark sites for lysosomal regulation of mitochondrial networks. However, mitochondrial contacts regulate lysosomal dynamics providing a new angle to studies of these organelles in neurodegenerative diseases.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Introduction Remarks: Past, Present and Future

Egbert MikDr. Egbert Mik, from University Medical Center Rotterdam, The Netherlands, will join the 12th Targeting Mitochondria Congress in October 2021, to give a talk entitled "Introduction Remarks: Past, Present and Future". 

During the sessin, Dr. Mik will explain the challenge of qualitative and quantitative assessment of mitochondrial function in vitro and in vivo, as well as future perspectives regarding this subject.

 

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

 

A Potential Mitochondrial Link Between Life Stress and the Reversibility of Hair Greying in Humans

Targeting Mitochondria 2021 Marin PicardDrMartin PicardAssociate professor of behavioral medicine at Columbia University Vagelos College of Physicians and Surgeons, USA will be joining the Targeting Mitochondria 2021 Congress and give a presentation entitled "A Potential Mitochondrial Link Between Life Stress and the Reversibility of Hair Greying in Humans".

Life stress causes neuroendocrine and metabolic alterations that influence mitochondria; and in turn, mitochondria produce signals and energy that influence pigment production that color our hairs. This presentation will describe a new approach to quantify human hair pigmentation patterns, demonstrating that human hair graying is rapidly reversible and linked to life stress. Individual hairs transitioning from their young-dark to old-white states, and reverting back to dark, show specific mitochondrial proteomic recalibrations pointing to a threshold-based metabolic mechanism for hair greying.

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Optimization of Energy Homeostasis in Old Age by SIRT6

Targeting Mitochondria 2021 Haim-CohenProf. Haim Cohen, head of the Molecular Mechanism of Aging Laboratory at Bar-Ilan University, Israel will be joining the Targeting Mitochondria 2021 Congress and give a presentation entitled "Optimization of Energy Homeostasis in Old Age by SIRT6".

Prof. Cohen's Studies in model organisms showed that the activity of the Sir2 family of NAD+-dependent protein deacetylases (sirtuins) is important in regulating lifespan in yeast, worms, and flies. He shows that overexpression of mammalian sirtuin SIRT6 in mice leads to a reduction in frailty and lifespan extension by ~30%. To do so, SIRT6 restores energy homeostasis of old animals through an improvement in the utilization of two major gluconeogenic precursors, lactate and glycerol.

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com