Mitochondria: The Key to Stem Cell Longevity and Anti-Aging Strategies

Mitochondria are at the heart of stem cell aging, influencing energy metabolism, oxidative stress, and cellular fate. As mitochondrial dysfunction accumulates with age, stem cells lose their regenerative potential, leading to tissue degeneration and age-related diseases. Cellular senescence is driven by increased ROS production, epigenetic modifications, and impaired mitophagy.

This review highlights innovative therapeutic strategies to counteract mitochondrial dysfunction, including antioxidants (MitoQ, nicotinamide riboside), mitochondrial biogenesis enhancers (AICAR, rapamycin), and mitophagy activators (Urolithin A, melatonin). Mitochondrial transfer from stem cells also emerges as a promising approach to restore function in aged tissues.

Targeting mitochondrial health represents a cutting-edge strategy to delay stem cell senescence and unlock new possibilities for regenerative medicine and longevity.

We remind you that we have a workshop dedicated to mitochondria transplantation during Targeting Mitochondria 2025 in Berlin. This hot topic will also be discussed during the 2nd World Congress on Targeting Longevity, where leading experts will explore the latest breakthroughs in mitochondrial research and anti-aging therapies.

For more details,  read the full article here.