Exploring Mitochondria-Containing Extracellular Vesicles in Alzheimer’s Disease Wins WMS Best Poster Presentation (2)
Congratulations to Tingting Chen from the University of Groningen, Netherlands, for receiving the Best Poster Presentation Award at the 15th Annual World Congress on Targeting Mitochondria!
Her groundbreaking research investigates mitochondria-containing extracellular vesicles (mitoEVs) and their role in Alzheimer's disease (AD).
Chen’s study involved isolating mitoEVs from neural progenitor cells (NPCs) derived from an AD patient with a PSEN1 mutation and comparing them with control cells. While no significant differences were observed in protein concentrations or particle sizes, proteomic analysis revealed a greater diversity of proteins in control EVs.
Dr. Chen stated to the WMS:
"Alzheimer’s disease (AD) affects millions of people worldwide and we do not have a cure for it. Dysfunctional intercellular communication contributes to the pathology of the disease. Extracellular vesicles (EVs) are now recognized as key components in cell–cell communication. During my research I investigate the role of mitochondria-containing EVs in AD pathology. Through proteomic analysis of EVs derived from the neural progenitor cells (NPCs) with the PSEN1 ΔE9 mutation, I aim to identify potential biomarkers for AD. This work aims to shed light on the connection between mitochondrial proteins in EVs and mitochondrial health within cells.
Ultimately, I hope to demonstrate the potential of mitochondria-containing EVs as a promising tool for tracking disease progression in early-stage AD."
