Mitochondria Delivery via Extracellular Vesicles to the Blood-Brain Barrier

Devika S ManickamDr. Devika S Manickam, Duquesne University, USA, and active member of the WMS Scientific Committee will be joining Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: Mitochondria Delivery via Extracellular Vesicles to the Blood-Brain Barrier


  • Role of extracellular vesicles (EVs) in intercellular communication and drug delivery.
  • Incorporation of mitochondria small EVs (<200 nm) and medium-to-large EVs (m/lEVs >200 nm) EVs during biogenesis.
  • Potential of m/lEVs to deliver healthy mitochondria for treating neurodegenerative, cardiovascular, and metabolic diseases.
  • Advantage of m/lEVs using endogenous mechanisms for cellular repair.
  • Impact of ischemic stroke on mitochondrial function in blood-brain barrier endothelial cells.
  • Efficacy of human brain endothelial cells (BEC) -derived mitochondria-containing EVs in mouse stroke models.
  • Improved therapeutic outcomes with species-specific EVs (mouse BEC-EVs) in stroke models.
  • Support for using m/lEVs to enhance therapeutic potential in preclinical studies.

World Mitochondria Society 
Annual World Congress on Targeting Mitochondria
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