DOI Assignment for Targeting Mitochondria 2024 Abstracts
We are pleased to announce that all abstracts submitted this year to the 15th Annual meeting of the WMS will be included in the Targeting Mitochondria 2024 Abstracts Book, which will be assigned a DOI (Digital Object Identifier). This ensures your work will have a permanent and easily accessible online presence.
Importance of DOI
Having a DOI means your abstracts will be indexed on major academic platforms such as ORCID, Google Scholar, Scopus and others. This not only enhances the visibility of your research but also facilitates easy citation and sharing within the scientific community.
Abstract Submission Details
You can submit your abstracts here: www.wms-site.com/abstract submission.
World Mitochondria Society 2024 Keynote Speaker Day 1: Prof. Eric Schon
WMS is happy to welcome Prof. Eric Schon from Columbia University, USA, as a keynote speaker on Day 1 of Targeting Mitochondria 2024 in Berlin this October.
Prof. Schon will deliver a presentation titled "Mitochondria in Alzheimer disease: it's not what you think"
The dominant hypothesis of Alzheimer disease (AD) pathogenesis invokes the accumulation of a cleavage product of the amyloid precursor protein (APP), called beta-amyloid, as the driver of pathogenesis. However, the poor track record of clinical trials based on this hypothesis suggests that other causes likely underlie the disease. We propose an alternative hypothesis in which a different APP cleavage product, called C99, is the main culprit, via its role as a regulator of cellular cholesterol metabolism. In AD, both C99 production and cellular cholesterol levels are increased well above normal levels, resulting in essentially all of the biochemical and clinical features of the disease. From this perspective, AD is, at bottom, a lipid disorder.
About Eric Schon
Eric Schon, a professor of Neurology and Genetics, has focused on the intricacies of mitochondrial genetics, highlighting their unique semi-autonomous nature governed by both nuclear and mitochondrial DNA. Mitochondria, once bacteria, contribute to cellular energy production through oxidative phosphorylation. Schon's research explores various inherited and sporadic mitochondrial disorders, employing innovative techniques like cytoplasmic hybrids. Recently, his focus shifted to Alzheimer's disease, uncovering heightened ER-mitochondrial communication as a potential key player in its pathogenesis, offering insights into diagnosis and treatment.
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World Mitochondria Society 2024 Keynote Speaker Day 2: Prof. Howy Jacobs
It is with great pleasure that we welcome Prof. Howy Jacobs from Tampere University, Finland, as a keynote speaker on Day 2 at Targeting Mitochondria 2024 in Berlin this October.
Prof. Jacobs has documented "A century of mitochondrial research, 1922–2022" in the Enzymes Book Series (2023). The chapter discussed the comprehensive research history of mitochondria, starting from their initial recognition as resembling bacteria in 1922, to their integration into cell physiology today, highlighting major advances in various scientific fields such as biochemistry, genetics, pathology, and cell biology.
Keynote Speech: "Mitochondria: More Heat Than Light?"
"Mitochondria are not just producers of ATP or clearing houses of intermediary metabolism. Here I will trace the history of how mitochondria have come to be regarded as key contributors to cell and organismal physiology, and how recent findings have opened up new chapters in our thinking" stated Prof. Jacobs.
Prof. Jacobs will discuss the implications of elevated mitochondrial temperature for evolution, development, cell signaling, immunity and pathology.
© Photo Credits: Rami Hanafi
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Cellular Dynamics: The Synergistic Interplay of Iron, Mitochondria, and Ferroptosis in Health and Disease
Prof. Carsten Culmsee, University of Marburg, Germany, and active member of the WMS Scientific Committee will be joining Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Cellular Dynamics: The Synergistic Interplay of Iron, Mitochondria, and Ferroptosis in Health and Disease.
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Mitochondrial Extracellular Vesicles: Orchestrating Brain Plasticity and Recovery
Prof. Stefano Pluchino, University of Cambridge, United Kingdom, will be joining Targeting Mitochondria 2024 this October in Berlin.
Prof. Pluchino will be sharing his latest research on the role of mitochondrial extracellular vesicles in brain plasticity and recovery, during the session dedicated to "Emerging Trends and Strategies in Mitochondria Research".
In his talk Prof. Pluchino will cover the the following:
- Extracellular vesicles from neural stem cells transfer IFN-g via Ifngr1 to activate Stat1 signalling in target cells
- Extracellular vesicles are independent metabolic units delivering functional Asparaginase-like protein 1n
- NSCs deliver functional mitochondria to target cells via EVs
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Mitochondria Delivery via Extracellular Vesicles to the Blood-Brain Barrier
Dr. Devika S Manickam, Duquesne University, USA, and active member of the WMS Scientific Committee will be joining Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondria Delivery via Extracellular Vesicles to the Blood-Brain Barrier
Highlights
- Role of extracellular vesicles (EVs) in intercellular communication and drug delivery.
- Incorporation of mitochondria small EVs (<200 nm) and medium-to-large EVs (m/lEVs >200 nm) EVs during biogenesis.
- Potential of m/lEVs to deliver healthy mitochondria for treating neurodegenerative, cardiovascular, and metabolic diseases.
- Advantage of m/lEVs using endogenous mechanisms for cellular repair.
- Impact of ischemic stroke on mitochondrial function in blood-brain barrier endothelial cells.
- Efficacy of human brain endothelial cells (BEC) -derived mitochondria-containing EVs in mouse stroke models.
- Improved therapeutic outcomes with species-specific EVs (mouse BEC-EVs) in stroke models.
- Support for using m/lEVs to enhance therapeutic potential in preclinical studies.
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Mitochondrial Transplantation Mediates Improved Cellular Energy Metabolism, Restoration of Mitochondrial Function and Prevention of Cell Death
It is a great pleasure to welcome Dr. Mark Kindy, U.S. Department of Veterans Affairs James A. Haley VA Hospital and University of South Florida, USA at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondria Iron Metabolism: Mitochondrial Transplantation Mediates Improved Cellular Energy Metabolism, Restoration of Mitochondrial Function and Prevention of Cell Death
In his talk Dr. Kindy will cover:
- Isolation and characterization of mitochondria
- Application of mitochondrial transplantation
- Reversal of cellular dysfunction
- Restoration of energy metabolism
Dr. Kindy is a collaboration partner of the WMS supporter 2024 "MitoSense". About Mitosense.
Targeting Mitochondria 2024 program.
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Cracking the Code of Aging: Exploring Mitochondrial Dynamics and Organelle Connections
It is a great pleasure to welcome Dr. Antentor Hinton, Vanderbilt University, USA, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Cracking the Code of Aging: Exploring Mitochondrial Dynamics and Organelle Connections.
Highlights
- Overview of the current understanding regarding mitochondrial structural changes during aging.
- Summary of the altered structural changes that occur with age in cristae architecture and their impact on mitochondrial calcium signaling.
- Implications of how aging modifies organelle contact communication.
- Illustration of how the MICOS (mitochondrial contact site and cristae organizing system) complex influences physiology and metabolism throughout the aging process.
More information on Dr. Hinton's latest research.
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Blood-Based Marker: Mitochondrial DNA Damage in Parkinson’s Disease
Dr. Laurie Sanders, Duke University School of Medicine, USA, will be joining Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Blood-Based Marker: Mitochondrial DNA Damage in Parkinson’s Disease
In this talk, Dr. Sanders will discuss the challenges in Parkinson's disease (PD) treatment and the need for better diagnostic tools. Mitochondrial dysfunction's role in PD's development will be highlighted, along with recent findings on mitochondrial DNA (mtDNA) damage. Dr. Sanders will introduce a PCR-based assay called MitoDNADX for quantifying mtDNA damage, showcasing its potential as a blood-based marker for PD. Preliminary results from patient studies and animal models will be presented, suggesting that this assay could aid in PD diagnosis and assessing the effectiveness of LRRK2 kinase inhibitors in treating the disease.
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The Role of Mitochondria in Zika Virus Propagation: Mechanisms of Immune Evasion and Inter-Cellular Transmission
It is a great pleasure to welcome Dr. Indira Mysorekar, Baylor College of Medicine, USA, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: The Role of Mitochondria in Zika Virus Propagation: Mechanisms of Immune Evasion and Inter-Cellular Transmission.
Highlights
- Mitochondrial dynamics in viral pathogenesis
- Use of Tunneling nanotubes for infecting neighbouring cells and siphoning mitochondria to fuel infection
More information on Dr. Mysorekar's latest research.
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Dynamics of Mitochondria: Regulation of Nucleoid Morphology to Protect Mitochondrial Function
Prof. Naotada Ishihara, Osaka University, Japan, will be joining Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Dynamics of Mitochondria: Regulation of Nucleoid Morphology to Protect Mitochondrial Function.
Highlights
- Discuss the connection between mitochondrial dynamics (fusion/fission) and the behavior of mtDNA nucleoids within the cell.
- Mitochondrial membrane activity influences the shape and distribution of mtDNA nucleoids.
- Abnormalities in both mitochondrial morphology and nucleoid structure are linked to certain diseases.
- Expose the new methods to manipulate nucleoid structures, improving mitochondrial and cellular functions in some pathogenic conditions.
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New Biosensing Solutions and Optimized Pharmacological Inhibitors to Counteract Mitophagy in Cancer Cells
It is a great pleasure to welcome Dr. Giulia Bertolin, Université de Rennes, France, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: New Biosensing Solutions and Optimized Pharmacological Inhibitors to Counteract Mitophagy in Cancer Cells
Highlights
- Mitochondria play vital roles in cell physiology, and dysfunctions are implicated in diseases like cancer and neurodegenerative disorders.
- Mitochondria are closely integrated with other cellular components, impacting functions such as cell cycle regulation and ATP production.
- The talk will explore how cancer cells exploit mitochondrial functions, focusing on the cell cycle protein AURKA, which is often overexpressed in breast cancer.
- Advanced fluorescence microscopy techniques are utilized to track AURKA activation in living samples, providing insights into its role in mitochondrial function.
- Ongoing research aims to develop sensitive biosensors for monitoring mitochondrial activation of AURKA and exploring pharmacological inhibitors to alter its interaction with mitophagy partners.
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Mitochondrial Dynamics in Health and Disease: Advances in Mood Disorders and Mitochondrial-Organ Transplantation
It is a great pleasure to welcome Dr. Ana Andreazza, University of Toronto, Canada at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondrial Dynamics in Health and Disease: Advances in Mood Disorders and Mitochondrial-Organ Transplantation
Points to be covered:
1. Mitochondrial Dynamics in Health and Disease:
Explore the essential role of mitochondria in energy balance, neuronal signaling, and cellular health. Emphasize their influence on the brain and other critical organs, underlining the importance of mitochondrial health in overall bodily function.
2. Linking Mitochondrial Dysfunction to Mood Disorders:
Explore the relationship between mitochondrial dysfunction and mood disorders. Present clinical evidence showing their correlation and introduce cutting-edge mitochondrial-targeted metabolomics to improve patient classification and treatment paths.
3. Innovative Therapeutic Approaches:
Discuss advancements in mitochondrial transplantation and the creation of the MitoGENE risk score. These innovations aim to refine diagnostic and therapeutic strategies, supported by data from real-world clinical trials.
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Mitochondria and Photomedicine: Advances in Infrared Light Treatment
Prof. Maik Hüttemann, Wayne State University, USA, and active member of the WMS Scientific Committee will be joining Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondria and Photomedicine: Advances in Infrared Light Treatment.
Highlights
- Brain ischemia followed by reperfusion leads to neuronal death due to mitochondrial dysfunction.
- Mitochondrial Dysfunction: Reperfusion causes hyperactivity in the electron transport chain, leading to cell death.
- Current pharmacological treatments have limitations in effectiveness and timing.
- Specific Near Infrared Light (IRL) wavelengths inhibit mitochondrial dysfunction noninvasively.
- New waveguide technology was developed for safe and efficient IRL delivery into the brain.
- IRL treatment reduces neuronal death in animal models.
- Cytochrome c-COX-inhibitory IRL emerges as a promising non-pharmacologic, noninvasive therapy for cerebral ischemia/reperfusion injury.
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Mitochondria Iron Metabolism: Its Role in Pathogenesis of Diseases
It is a great pleasure to welcome Dr. Sonia Levi, Vita-Salute San Raffaele University, Italy, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondria Iron Metabolism: Its Role in Pathogenesis of Diseases
In her talk Dr. Levi will cover the following:
- Discuss the importance of iron in the physiology of mitochondria.
- Mitochondria as the critical controllers of cellular iron homeostasis and their involvement in the mechanism of ferroptosis, an iron-dependent form of cellular death driven by lipid peroxidation.
- Example of how mitochondrial iron-deficiency and -overload impair mitochondrial metabolism, promoting disease development.
- Focus on mitochondrial iron-imbalance role in the initiation and progression of neurodegenerative diseases.
More information on Dr. Mysorekar's latest research.
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