Targeting Giant Mitochondria (Megamitochondria) in Human Liver Disease: Potential Diagnostic and Therapeutic Interventions
It is a great pleasure to welcome Dr. Elena Palma, King's College London, United Kingdom, at Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Targeting Giant Mitochondria (Megamitochondria) in Human Liver Disease: Potential Diagnostic and Therapeutic Interventions.
Key Points
- Megamitochondria are disproportionately enlarged organelles with regular paracrystalline inclusions.
- Their significance and how they form are still under debate.
- Their detection has strikingly been linked to improved survival among patients with Alcohol-related liver disease.
- New models are needed to investigate this intriguing phenomenon and human precision cut liver slices represent a crucial advance for this purpose.
About Elena Palma
One of Dr. Palma's interests is developing ex vivo experimental models to study liver diseases and malignancies, using dynamic cultures of human precision-cut tissue slices.
Her research investigates the role of mitochondria in the pathogenesis and progression of Alcohol-related liver diseases with the final aim to target these organelles for therapeutic purposes.
World Mitochondria Society
Annual World Congress on Targeting Mitochondria
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