Mitochondria Delivery via Extracellular Vesicles to the Blood-Brain Barrier
Dr. Devika S Manickam, Duquesne University, USA, and active member of the WMS Scientific Committee will be joining Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Mitochondria Delivery via Extracellular Vesicles to the Blood-Brain Barrier
Highlights
- Role of extracellular vesicles (EVs) in intercellular communication and drug delivery.
- Incorporation of mitochondria small EVs (<200 nm) and medium-to-large EVs (m/lEVs >200 nm) EVs during biogenesis.
- Potential of m/lEVs to deliver healthy mitochondria for treating neurodegenerative, cardiovascular, and metabolic diseases.
- Advantage of m/lEVs using endogenous mechanisms for cellular repair.
- Impact of ischemic stroke on mitochondrial function in blood-brain barrier endothelial cells.
- Efficacy of human brain endothelial cells (BEC) -derived mitochondria-containing EVs in mouse stroke models.
- Improved therapeutic outcomes with species-specific EVs (mouse BEC-EVs) in stroke models.
- Support for using m/lEVs to enhance therapeutic potential in preclinical studies.
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Annual World Congress on Targeting Mitochondria
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Mitochondrial Extracellular Vesicles: Orchestrating Brain Plasticity and Recovery
Prof. Stefano Pluchino, University of Cambridge, United Kingdom, will be joining Targeting Mitochondria 2024 this October in Berlin.
Prof. Pluchino will be sharing his latest research on the role of mitochondrial extracellular vesicles in brain plasticity and recovery, during the session dedicated to "Emerging Trends and Strategies in Mitochondria Research".
In his talk Prof. Pluchino will cover the the following:
- Extracellular vesicles from neural stem cells transfer IFN-g via Ifngr1 to activate Stat1 signalling in target cells
- Extracellular vesicles are independent metabolic units delivering functional Asparaginase-like protein 1n
- NSCs deliver functional mitochondria to target cells via EVs
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Cellular Dynamics: The Synergistic Interplay of Iron, Mitochondria, and Ferroptosis in Health and Disease
Prof. Carsten Culmsee, University of Marburg, Germany, and active member of the WMS Scientific Committee will be joining Targeting Mitochondria 2024 this October in Berlin.
Presentation title: Cellular Dynamics: The Synergistic Interplay of Iron, Mitochondria, and Ferroptosis in Health and Disease.
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Annual World Congress on Targeting Mitochondria
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Stem Cell Educator Therapy: A New Era in Mitochondrial Transfer and Regeneration
Dr. Yong Zhao, Throne Biotechnologies, will be joining Targeting Mitochondria 2024 this October in Berlin.
Dr. Zhao will be sharing his latest research on stem cells and mitochondrial transfer in a talk entitled "Stem Cell Educator Therapy: A New Era in Mitochondrial Transfer and Regeneration".
Presentation Highlights
1. Stem Cell Educator (SCE) therapy is the only therapy to date to safely and efficiently correct autoimmunity and restore β cell function in recent onset T1D patients.
2. Clinical data provided the visual evidence regarding the immune education of SCE therapy, leading the long-lasting improvement of hair regrowth in subjects with moderate or severe alopecia areata (AA).
3. SCE therapy has the potential to revolutionize the treatment of patients with other autoimmune and inflammatory- or aging-associated diseases caused by mitochondrial dysfunctions, without the safety and ethical concerns associated with conventional immune and/or stem cell-based approaches.
Join us to know more! Speakers Lineup.
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World Mitochondria Society 2024 Keynote Speaker Day 2: Prof. Howy Jacobs
It is with great pleasure that we welcome Prof. Howy Jacobs from Tampere University, Finland, as a keynote speaker on Day 2 at Targeting Mitochondria 2024 in Berlin this October.
Prof. Jacobs has documented "A century of mitochondrial research, 1922–2022" in the Enzymes Book Series (2023). The chapter discussed the comprehensive research history of mitochondria, starting from their initial recognition as resembling bacteria in 1922, to their integration into cell physiology today, highlighting major advances in various scientific fields such as biochemistry, genetics, pathology, and cell biology.
Keynote Speech: "Mitochondria: More Heat Than Light?"
"Mitochondria are not just producers of ATP or clearing houses of intermediary metabolism. Here I will trace the history of how mitochondria have come to be regarded as key contributors to cell and organismal physiology, and how recent findings have opened up new chapters in our thinking" stated Prof. Jacobs.
Prof. Jacobs will discuss the implications of elevated mitochondrial temperature for evolution, development, cell signaling, immunity and pathology.
© Photo Credits: Rami Hanafi
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Annual World Congress on Targeting Mitochondria
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World Mitochondria Society 2024 Keynote Speaker Day 1: Prof. Eric Schon
WMS is happy to welcome Prof. Eric Schon from Columbia University, USA, as a keynote speaker on Day 1 of Targeting Mitochondria 2024 in Berlin this October.
Prof. Schon will deliver a presentation titled "Mitochondria in Alzheimer disease: it's not what you think"
The dominant hypothesis of Alzheimer disease (AD) pathogenesis invokes the accumulation of a cleavage product of the amyloid precursor protein (APP), called beta-amyloid, as the driver of pathogenesis. However, the poor track record of clinical trials based on this hypothesis suggests that other causes likely underlie the disease. We propose an alternative hypothesis in which a different APP cleavage product, called C99, is the main culprit, via its role as a regulator of cellular cholesterol metabolism. In AD, both C99 production and cellular cholesterol levels are increased well above normal levels, resulting in essentially all of the biochemical and clinical features of the disease. From this perspective, AD is, at bottom, a lipid disorder.
About Eric Schon
Eric Schon, a professor of Neurology and Genetics, has focused on the intricacies of mitochondrial genetics, highlighting their unique semi-autonomous nature governed by both nuclear and mitochondrial DNA. Mitochondria, once bacteria, contribute to cellular energy production through oxidative phosphorylation. Schon's research explores various inherited and sporadic mitochondrial disorders, employing innovative techniques like cytoplasmic hybrids. Recently, his focus shifted to Alzheimer's disease, uncovering heightened ER-mitochondrial communication as a potential key player in its pathogenesis, offering insights into diagnosis and treatment.
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Dinner at Targeting Mitochondria Congress 2024: Join Us for an Evening of Networking!
An official and optional dinner will be held on Wednesday, October 30th, 2024, at DoubleTree by Hilton Berlin Ku'Damm with speakers and members of the scientific committee of WMS. Attendees are welcome to register and join the dinner.
This dinner offers attendees the opportunity to continue discussions from the day's sessions in a more informal setting. The event includes:
- A four-course dinner featuring local and international cuisine
- Complimentary drinks: wine and beer
- Coffee
Seating is limited, so early reservation is recommended. Register now.
We look forward to welcoming you to this special dinner.
More about the hotel and the access.
Please note that registration to the dinner tickets is non-refundable. However, you can be transfer it to colleagues as substitutes.
World Mitochondria Society
15th Targeting Mitochondria 2024 Congress
October 29-31, 2024 - Berlin, Germany
www.wms-site.com
Posters List of Targeting Mitochondria 2024
More than 112 communications were presented during Targeting Mitochondria 2024, including more than 70 posters. Access full posters list.
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