iPSC-based drug discovery for neurological mitochondrial disease: presentation of recent scientific data
Mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases. Modeling of these defects has been difficult because of the challenges associated with engineering mtDNA. Patient-derived induced pluripotent stem cells (iPSCs) allow the development of innovative cellular models in a personalized approach.
During Targeting Mitochondria World Congress, Dr Alessandro Prigione from Max Delbrueck Center for Molecular Medicine, Germany will discuss the potential benefits of patient iPSCs for drug discovery of neurological mitochondrial diseases.
To access to the preliminary agenda, please click here.
What is the impact of mitochondria-targeted antioxidants on cancer progression?
ROS can be produced at different sites in cells: it can be formed in the plasma membrane, the cytosol, but the main ROS generator is the electron transport chain (ETC) located in the mitochondrial matrix. Interestingly, enhanced or disrupted mitochondrial activity can increase superoxide production within the mitochondria of cancer cells. The increased superoxide production has been associated with cell survival and metastasis. Thus, it has been hypothesized that specifically targeting mitochondrially-produced ROS could reduce the survival and invasive abilities of cancer cells. Consequently, several mitochondrial antioxidants have been developed and tested; but thus far, no studies have defined the impact of mitochondria-targeted antioxidants on the progression of cancer in endogenous mouse models.
In this talk, Pr Martin Bergö from Sahlgrenska Cancer Center, Sweden, will give an update of their experiments designed to address this issue.
For more information about Targeting Mitochondria Congress: www.targeting-mitochondria.com
Self-Assembled Polymeric Nanoparticle for Mitochondria-Targeting Drug Delivery
Dr Han Chang Kang, from the Department of Pharmacy, The Catholic University of Korea, Republic of Korea will present his recent research about the Self-Assembled Polymeric Nanoparticle for Mitochondria-Targeting Drug Delivery.
Recently, subcellular targeting drug delivery systems that specifically reach subcellular compartments (e.g., cytosol, nucleus, and mitochondria) of interest have garnered more attention because their action sites for generating therapeutic effects occur not just at the cellular level but at the subcellular level as well. Among them, this presentation will be focused on mitochondria-targeting self-assembled polymer-based nanoparticles for intracellular drug delivery because mitochondria are very significant intracellular organelles for controlling the homeostasis of vital physiological functions and synthesizing bioenergy molecules and their dysfunction leads to a variety of human disorders including neurodegenerative, neuromuscular, cardiac, and metabolic diseases. The significance of the mitochondria in disease allows a broad spectrum of therapeutics to strengthen or weaken their intrinsic or newly-introducing functions. Thus, the presentation will introduce the mitochondria-targeting drug delivery systems designed by me and my collaborators.
For more information about Targeting Mitochondria Congress: www.targeting-mitochondria.com
Presentation of the mitochondrial DNA damaged induced inflammation in lung epithelial cells
Dr Bartosz Szczesny, Associate Professor at the Department of Anesthesiology of the University of Texas Medical Branch at Galveston, USA is invited during Targeting Mitochondria World Congress is to give a presentation about the mitochondrial DNA damaged induced inflammation in lung epithelial cells.
According to Dr Szczesny: "Pulmonary epithelial cells are key effectors and targets in the pathogenesis of inflammatory lung diseases such as asthma, and chronic obstructive pulmonary disease, among others. Oxidative stress has been implicated at the earliest step in development of lung inflammation, but the molecular mechanisms of how oxidantive injury to epithelial cells develops inflammatory response remain unclear. While investigating the mechanisms responsible for activating inflammation in response to prolonged, low-level oxidative stress, we identified a role for an active and selective cellular extrusion of damaged mitochondrial DNA, that did not affect cellular viability. Selective release of damaged mitochondrial DNA, first into the cytoplasm and subsequently into the extracellular space, triggers autocrine and paracrine modes of the inflammatory response. I will be discussing cellular outcomes and inflammatory signaling pathways in response to mitochondrial DNA-specific damage in cell culture and in vivo models."
More information about the congress: www.targeting-mitochondria.com
The registrations for Targeting Mitochondria 2017 World Congress are now open!
On behalf of the Scientific Committee of World Mitochondria Society, we are pleased to inform you that the 8th World Congress on Targeting Mitochondria will be organized on October 23 and 24, 2017 at Steigenberger Hotel, in Berlin.
You can now register to the congress with the very early bird rates before March 21, at midnight, by clicking here.
You can also submit your abstract until September 14 for short oral presentation and until September 28 for poster presentation here.
We look forward to meeting you in Berlin next October.
World Mitochondria Society
www.targeting-mitochondria.com
Pr Marvin Edeas and Pr Volkmar Weissig commented the 7th World Congress on Targeting Mitochondria 2016
The 7th World Congress on Targeting Mitochondria was organized in Berlin on October 24-26, 2016. This seventh edition was again a huge success and gathered more than 350 attendees, academics, industrials and start-ups during three days, representing more than 27 countries.
The scientific committee validated more than 170 communications (oral and poster) which have highlighted the recent scientic advances on mitochondria and all related researches such as the methods to evaluate mitochondria function/dysfunction, but also new strategies to target the mitochondria. To access to the final program of the congress, please follow this link.
Pr Volkmar Weissig, from the Midwestern University commented: “As President of the WMS I am extremely happy about the success of our 7th World Conference on Targeting Mitochondria. I would like to personally thank the organizing team for the excellent work they have done in planning and setting up this conference. Of course, any conference is just as good as its participants. Therefore I sincerely thank all invited speakers, all presenters of short oral communications and all poster presenters for their excellent contributions. I also would like to thank all other attendees for participating in our conference. Our conference series has over the last years significantly grown with respect to the number of registrations. With over 310 participants from almost all continents we have set a new a record. I believe our conference series has established itself as a major event in the international “mitochondrial landscape”. If I may say so, mitochondria have found a home in Berlin! With excitement I am already looking forward to the 8th edition next year and I sincerely hope to see most if not all of you again one year from now.”
From his side, Pr Marvin Edeas, from Institut Cochin, INSERM U1016, University Paris Descartes commented: "The world of mitochondria is "hyper-dynamic". Mitochondria is a very dynamic organelle, it moves, oscillates and communicates with cells and in particular with microbiota. We need to re-design a "dynamic" strategy to target mitochondria in all its dimensions. This strategy must integrate all factors and actors (microbiota).
Again, as founder of WMS and co-chairman of the scientific committee, I believe that mitochondria-microbiota inter-talk is one of the perfect target to highlight."
To conclude this three-day meeting, the scientific awarded two scientists for their research:
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Daniel Schniertshauer from the Albstadt-Sigmaringen University of Applied Sciences, Germany for his poster presentation about "Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10". For more information about this award, please click here. |
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François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling". For more information about this award, please click here. |
The dates of Targeting Mitochondria 2017 will be announced very soon on the website.
World Mitochondria Society
www.targeting-mitochondria.com
The award for the short oral presentation was discerned to François Mouton-Liger
At the end of Targeting Mitochondria World Congress, Pr Volkmar Weissig and Pr Marvin Edeas awarded two scientists for their research. Among them:
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François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".
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The second award was discerned to Daniel Schniertshauer from the Albstadt-Sigmaringen University of Applied Sciences, Germany for his poster presentation about "Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10".
For more information about this award, please click here.
World Mitochondria Society
Daniel Schniertshauer was awarded for his poster presentation during Targeting Mitochondria 2016
At the end of Targeting Mitochondria World Congress, Pr Volkmar Weissig and Pr Marvin Edeas awarded two scientists for their research. Among them:
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Daniel Schniertshauer from the Albstadt-Sigmaringen University of Applied Sciences, Germany for his poster presentation about "Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10". You can download his poster by clicking here.
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Testimonial by Dr Schniertshauer: "The 7th World Congress on Targeting Mitochondria was the second time I was allowed to attend this conference after 2015. The participation of several hundred participants from all over the world at the last congress showed me the importance of this event in the research community of mitochondria. As last year, I was already looking forward to the most diverse presentations, the nice conversations with colleagues and the establishment of contacts between the lectures. In addition, the daily poster sessions were excellent for picking up the one or the other piece of advice from experienced colleagues.
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François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".
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The second award was discerned to François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".
For more information about this award, please click here.
World Mitochondria Society
Organize a meeting with the leaders in mitochondria field
Targeting Mitochondria attendees, academics and industrials, are invited to a warm-up networking session over the lunch and coffee breaks. Already more than 300 registrants!
Pr Vladimir Skulachev talked about prolongation of youth by delay of ontogenesis (neoteny) or by a mitochondria-targeted antioxidant
Pr Vladimir Skulachev from the University of Moscow, Russia was invited by the scientific committee of the 7th World Congress on Targeting Mitochondria to present his recent resultats of the clinical trial done with SkQ1.
Mitochondrial protein import defect in Huntington’s disease will be highlighted by Robert Friedlander
Dr. Robert Friedlander, chairman Department of Neurological Surgery from UPMC Presbyterian Hospital, Pittsburgh, USA was invited by Marvin Edeas and Volkmar Weissig to talk about:
- Role of mitochondrial protein import in Huntington's disease
- Site specific mitochondrial vulnerability.
- Interaction of mutant huntington with TIM23
For more information: www.targeting-mitochondria.com
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
What is the role of mitochondrial ROS in neutrophil-mediated inflammation and autoimmunity?
Dr Christian Lood from the University of Washington, USA was invited by the scientific committee of Targeting Mitochondria Congress to present his recent data related to the role of mitochondrial ROS in neutrophil-mediated inflammation and autoimmunity.
Marvin Edeas and Volkmar Weissig, chairmen of the conference, stated: "Dr Lood will present some of the recent data on the role of mitochondria in neutrophil-mediated inflammation and autoimmunity. In particular, he will highlight the following points:
- role of mitochondrial ROS in induction of neutrophil programmed necrosis, neutrophil extracellular trap (NET) formation, and its implications in autoimmunity such as vasculitis and systemic lupus erythematosus (SLE)
- how released mitochondrial DNA may confer inflammation through the recently described DNA-sensing cGAS-STING pathway
- description of some potential approaches to limit mitochondrial-mediated damage in SLE"
If you are interested to know more about mitochondria, inflammation and autoimmunity, don't hesitate to register to Targeting Mitochondria 2016: www.targeting-mitochondria.com
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
Monitoring mitochondrial oxygenation and oxygen consumption: first clinical experiences
One of the session of Targeting Mitochondria 2016 is dedicated to "How to evaluate mitochondrial function/dysfunction?". This session will be organized during the second day of the congress.
Pr Egbert Mik from Erasmus MC, Netherlands will be one of the major speaker of this strategic session. He will present the first clinical experiences related to monitoring mitochondrial oxygenation and oxygen consumption.
Marvin Edeas & Volkmar Weissig asks to Egbert Mik to highlight the following key points:
- How to measure mitochondrial oxygenation and oxygen consumption in vivo?
- Is monitoring at the sub-cellular level feasible in clinic?
- How will mitochondrial measurements affect patient care?
If you are interested to know more about this technic, don't hesitate to register on www.targeting-mitochondria.com
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
Stem Cells and Mitochondria: Probing MT-ATP6 mutations using iPSC-derived neural cells
Carmen Lorenz is researcher at Max Delbrueck Center for Molecular Medicine (MDC) in Berlin, Germany.
During Targeting Mitochondria World Congress, she will present her recent studies about "Probing MT-ATP6 mutations using iPSC-derived neural cells".
Volkmar Weissig and Marvin Edeas asked to Carmen Lorenz to highlight the following strategic points:
- Are iPSC-derrived neural cells a good model system for mitochondrial diseases?
- Can we find treatments for mitochondrial diseases?
- Can we detect a disease phenotype of mitochondrial neurological disorders in a dish?
Marvin Edeas stated: "Targeting Mitochondria and stem cells is one of the hot topics that we will largely discuss during Targeting Mitochondria 2016".
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
www.targeting-mitochondria.com
What about skin photoprotection, UV-mediated damage and mitochondria?
Volkmar Weissig and Marvin Edeas invited Dr Olivier Reelfs from the University of Bath, United Kingdom to give a presentation about a powerful mitochondria-targeted iron chelator affords high photoprotection against solar UVA radiation.
During his presentation, Dr Reelfs will answer the following questions:
- What is the impact of mitochondrial iron in solar UV-mediated damage?
- What is the impact of mitochondria-targeted iron chelator for skin photoprotection?
- What does our mitochondria-targeted iron sensors say about mitochondrial iron overload disease?
If you are interested to know more about skin photoprotection, Uv-mediated damage and mitochondria, don't hesitate to register for Targeting Mitochondria World Congress on www.targeting-mitochondria.com
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
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