The award for the short oral presentation was discerned to François Mouton-Liger

At the end of Targeting Mitochondria World Congress, Pr Volkmar Weissig and Pr Marvin Edeas awarded two scientists for their research. Among them:

Francois-Mouton-Liger Award Targeting Mitochondria 2016

François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".

 

 

Testimonial by Dr Mouton-Liger: "Understanding mechanisms by which mitochondrial dysfunction contributes to the pathophysiological processes of neurodegenerative disorder, in particular Parkinson disease, will need in the future an integrated vision of all mitochondrial aspects from emerging methods to evaluate mitochondria function to new molecular interactions link to this organelle. By this way, the 7th World Congress on Targeting Mitochondria was, for me, a huge success by connecting remarkable researchers from such different area of the field, For these reasons, it will be a great pleasure for me to participate to this conference next year."

 

The second award was discerned to Daniel Schniertshauer from the Albstadt-Sigmaringen University of Applied Sciences, Germany for his poster presentation about "Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10". 

For more information about this award, please click here.

World Mitochondria Society

Daniel Schniertshauer was awarded for his poster presentation during Targeting Mitochondria 2016

At the end of Targeting Mitochondria World Congress, Pr Volkmar Weissig and Pr Marvin Edeas awarded two scientists for their research. Among them:

Daniel Schniertshauer Award Targeting Mitochondria 2016

Daniel Schniertshauer from the Albstadt-Sigmaringen University of Applied Sciences, Germany for his poster presentation about "Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10". You can download his poster by clicking here.

 

 

Testimonial by Dr Schniertshauer: "The 7th World Congress on Targeting Mitochondria was the second time I was allowed to attend this conference after 2015. The participation of several hundred participants from all over the world at the last congress showed me the importance of this event in the research community of mitochondria. As last year, I was already looking forward to the most diverse presentations, the nice conversations with colleagues and the establishment of contacts between the lectures. In addition, the daily poster sessions were excellent for picking up the one or the other piece of advice from experienced colleagues.
It was inspiring to see how researchers with a wide range of topics are interested in the current research, exploring them and are interested in the contributions of the other presenters. For me this was living science!
I think, not only for young doctoral students, the visit of such a congress is highly recommended, because through the diversity of topics you get insights into other areas of mitochondrial research and thus you can look beyond the box. The aim of such an event should be to make the knowledge of current themed lectures tangible for your own research. I'm really looking forward to the next Targeting Mitochondria."

 

 

Francois-Mouton-Liger Award Targeting Mitochondria 2016

François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".

 

Testimonial by Dr Mouton-Liger: "Understanding mechanisms by which mitochondrial dysfunction contributes to the pathophysiological processes of neurodegenerative disorder, in particular Parkinson disease, will need in the future an integrated vision of all mitochondrial aspects from emerging methods to evaluate mitochondria function to new molecular interactions link to this organelle. By this way, the 7th World Congress on Targeting Mitochondria was, for me, a huge success by connecting remarkable researchers from such different area of the field, For these reasons, it will be a great pleasure for me to participate to this conference next year."

 

The second award was discerned to François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".

For more information about this award, please click here.

World Mitochondria Society

Organize a meeting with the leaders in mitochondria field

Targeting-Mitochondria-Network-SessionTargeting Mitochondria attendees, academics and industrials, are invited to a warm-up networking session over the lunch and coffee breaks. Already more than 300 registrants!

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Pr Vladimir Skulachev talked about prolongation of youth by delay of ontogenesis (neoteny) or by a mitochondria-targeted antioxidant

Vladimir Skulachev Targeting MitochondriaPr Vladimir Skulachev from the University of Moscow, Russia was invited by the scientific committee of the 7th World Congress on Targeting Mitochondria to present his recent resultats of the clinical trial done with SkQ1.

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Mitochondrial protein import defect in Huntington’s disease will be highlighted by Robert Friedlander

Robert Friedlander Targeting MitochondriaDr. Robert Friedlander, chairman Department of Neurological Surgery from UPMC Presbyterian Hospital, Pittsburgh, USA was invited by Marvin Edeas and Volkmar Weissig to talk about:

  • Role of mitochondrial protein import in Huntington's disease
  • Site specific mitochondrial vulnerability.
  • Interaction of mutant huntington with TIM23

For more information: www.targeting-mitochondria.com

Marvin Edeas / Volkmar Weissig / Chairmen of WMS

What is the role of mitochondrial ROS in neutrophil-mediated inflammation and autoimmunity?

Targeting Mitochondria Lood

Dr Christian Lood from the University of Washington, USA was invited by the scientific committee of Targeting Mitochondria Congress to present his recent data related to the role of mitochondrial ROS in neutrophil-mediated inflammation and autoimmunity.

Marvin Edeas and Volkmar Weissig, chairmen of the conference, stated: "Dr Lood will present some of the recent data on the role of mitochondria in neutrophil-mediated inflammation and autoimmunity. In particular, he will highlight the following points:

- role of mitochondrial ROS in induction of neutrophil programmed necrosis, neutrophil extracellular trap (NET) formation, and its implications in autoimmunity such as vasculitis and systemic lupus erythematosus (SLE)

- how released mitochondrial DNA may confer inflammation through the recently described DNA-sensing cGAS-STING pathway

- description of some potential approaches to limit mitochondrial-mediated damage in SLE"

If you are interested to know more about mitochondria, inflammation and autoimmunity, don't hesitate to register to Targeting Mitochondria 2016: www.targeting-mitochondria.com

Marvin Edeas / Volkmar Weissig / Chairmen of WMS

Monitoring mitochondrial oxygenation and oxygen consumption: first clinical experiences

Egbert Mik Targeting Mitochondria

One of the session of Targeting Mitochondria 2016 is dedicated to "How to evaluate mitochondrial function/dysfunction?". This session will be organized during the second day of the congress.

Pr Egbert Mik from Erasmus MC, Netherlands will be one of the major speaker of this strategic session. He will present the first clinical experiences related to monitoring mitochondrial oxygenation and oxygen consumption.

Marvin Edeas & Volkmar Weissig asks to Egbert Mik to highlight the following key points:

  • How to measure mitochondrial oxygenation and oxygen consumption in vivo?
  • Is monitoring at the sub-cellular level feasible in clinic?
  • How will mitochondrial measurements affect patient care?

If you are interested to know more about this technic, don't hesitate to register on www.targeting-mitochondria.com  

Marvin Edeas / Volkmar Weissig / Chairmen of WMS 

 

Stem Cells and Mitochondria: Probing MT-ATP6 mutations using iPSC-derived neural cells

Carmen Lorenz Targeting MitochondriaCarmen Lorenz is researcher at Max Delbrueck Center for Molecular Medicine (MDC) in Berlin, Germany.

During Targeting Mitochondria World Congress, she will present her recent studies about "Probing MT-ATP6 mutations using iPSC-derived neural cells".

Volkmar Weissig and Marvin Edeas asked to Carmen Lorenz to highlight the following strategic points:

  • Are iPSC-derrived neural cells a good model system for mitochondrial diseases?
  • Can we find treatments for mitochondrial diseases?
  • Can we detect a disease phenotype of mitochondrial neurological disorders in a dish?

Marvin Edeas stated: "Targeting Mitochondria and stem cells is one of the hot topics that we will largely discuss during Targeting Mitochondria 2016".

Marvin Edeas / Volkmar Weissig / Chairmen of WMS
www.targeting-mitochondria.com

 

What about skin photoprotection, UV-mediated damage and mitochondria?

Oliver Reelfs Targeting MitochondriaVolkmar Weissig and Marvin Edeas invited Dr Olivier Reelfs from the University of Bath, United Kingdom to give a presentation about a powerful mitochondria-targeted iron chelator affords high photoprotection against solar UVA radiation.

During his presentation, Dr Reelfs will answer the following questions:

  • What is the impact of mitochondrial iron in solar UV-mediated damage?
  • What is the impact of mitochondria-targeted iron chelator for skin photoprotection?
  • What does our mitochondria-targeted iron sensors say about mitochondrial iron overload disease?

If you are interested to know more about skin photoprotection, Uv-mediated damage and mitochondria, don't hesitate to register for Targeting Mitochondria World Congress on www.targeting-mitochondria.com

Marvin Edeas / Volkmar Weissig / Chairmen of WMS

 

 

What is the role of miR-181 family in the heart?

Samarjit Das Targeting MitochondriaDr Samarjit Das is a researcher at the Department of Pathology, Johns Hopkins University, Baltimore, USA.

According Marvin Edeas and Volkmar Weissig, Dr Das was invited to Targeting Mitochondria 2016 to talk about the precise experimental basis of the novel concept that mitochondrial microRNA (MitomiR) can regulate mitochondrial reactive oxygen species (ROS) production in the heart, and thereby influence myocardial disease development and progression.

Importantly, Dr Das will try to demonstrate the mechanist inside by which one microRNA can derived from the nuclear genome, matured in the cytoplasm, and then translocates to the mitochondria, and more importantly, regulates mitochondrial gene expression to affect mitochondrial function.

Finally, Dr Das will also show one example, where some of the family members of one microRNA can translocate into the mitochondria, and functionally active inside the mitochondria. However, other family members primarily targets nuclear gene in the cytoplasmic fraction.

If you would like to access to the program and registration: www.targeting-mitochondria.com

Marvin Edeas / Volkmar Weissig / Chairmen of WMS

 

Subunit of mitochondria and hypertension control via miRNA: Presentation of the recent studies by Dao Wen Wang

Dr Wang

The scientific committee of the World Mitochondria Society, chaired by Marvin Edeas and Volkmar Weissig, is honoured to welcome Dr  Dao Wen Wang from Huazhong University of Science and Technology, China for the 7th World Congress on Targeting Mitochondria to be held in Berlin on October 24-26, 2016.

Dr Dao Wen Wang will talk about his research of "Subunit of mitochondria and hypertension control via miRNA" and will answer the following questions:

1. It has been widely accepted that miRNAs negatively regulate gene expression in the cytoplasm: why miRNAs positively regulate gene expression in the mitochondria?

2. You suggest that miR-21 lowers blood pressure by regulating mitochondrial gene expression and ROS production. However, a single miRNA has many different targets. It could be the miR-21 which resides in the cytoplasm doing the job instead.

3. MiR-21 has been extensively studied in cardiovascular diseases, silencing of miR-21 has been found to reduce cardiac fibrosis by previous studies, however, in your work, overexpression of miR-21reduces cardiac fibrosis, why?

 If you are interested to know more about this study, you can register to the congress on www.targeting-mitochondria.com

Marvin Edeas / Volkmar Weissig / Chairmen of WMS

Mitochondrial targeting of RNA as a tool for therapy

Dr Ivan Tarassov, the ResearIvan Tch Director in the CNRS, France, will join the 7th World Congress on Targeting Mitochondria and present his research topic on "Mitochondrial targeting of RNA as a tool for therapy"

Volkmar Weissig and Marvin Edeas invited Dr Tarassov to highlight the following strategic points:

1. Mechanisms and functional role of mitochondrial import of RNA

2. Allotopic strategy for mitochondrial therapy

3. Antigenomic strategy for mitochondrial therapy

 

If you are interested to know more about the speakers and the congress, don't hesitate to register to Targeting Mitochondria 2016: www.targeting-mitochondria.com

Marvin Edeas / Volkmar Weissig / Chairmen of WMS

Glutathione depletion induces mitochondrial damage through CYLD and associated pathways of regulated necrosis

Carsten Culmsee targeting mitochondria World congressVolkmar Weissig and Marvin Edeas invited Carsten Culmsee to join the 7th World Congress on Targeting Mitochondria and to talk about new concept "Glutathione depletion induces mitochondrial damage through CYLD and associated pathways of regulated necrosis".

This new concept links mechanisms of oxidative stress to induction of regulated necrosis independent of death receptor signaling but through activation of the deubiquitinase CYLD. Further, this endogenous pathway of regulated necrosis leads to mitochondrial damage through activation of Drp-1 but not MLKL and is also highly relevant in neuronal death following acute brain injury as shown in models of cerebral ischemia and brain trauma.

Volkmar Weissig / Marvin Edeas / Chairmen of WMS
www.targeting-mitochondria.com

Mitochondria Targeted Nanoparticle for Regenerative Therapy of Stroke

Shanta Dhar 7th World Congress on Targeting MitochondriaDr.  Shanta Dhar, from University of Georgia, USA  was invited by the scientific committee of the 7th World Congress on Targeting Mitochondria to present his recent  research "Mitochondria Targeted Nanoparticle for Regenerative Therapy of Stroke".

According to Dr. Dhar: Stroke is one of the most leading cause of impairment and death worldwide. Tissue plasminogen activator, the only Food and Drug Administration approved drug for ischemic stroke, suffers from several drawbacks when efficacy, safety, and the therapeutic window are considered. Neural stem cell-based tissue regeneration therapy can be an attractive addition for treatment of brain injuries. However, regenerative stem cell treatment suffers survival issues when implanted at the injury site dominated by a cytotoxic environment created by reactive oxygen species and inflammation. Neuro-protectants such as anti-inflammatory and/or anti-oxidative agents can be excellent addition to regenerative treatment.

Marvin Edeas stated: "During Targeting Mitochondria 2016, the new topic of mitochondria targeting nanoparticle will be largely discussed".

To know more about this strategic topic, you can register to Targeting Mitochondria World Congress on www.targeting-mitochondria.com

 Marvin Edeas / Volkmar Weissig / Chairmen of WMS

Tissue specificity of mitochondrial energy metabolism

Norbert Gellerich Targeting Mitochondria60 years ago Britton Chance started to investigate the regulation of mitochondrial function. He defined the well known states of OXPHOS, describing the ADP phosphorylation in dependence on the cell work and the availability of oxygen and substrates. Later it was found that cytosolic calcium regulates both, the cell work and the mitochondrial activity. Rate of OXPHOS is determined by the rate of ADP transport into the mitochondria via creatine phosphate shuttle and direct diffusion as well as by a sufficient substrate supply to mitochondria. Mitochondrial properties depend on the cell type under investigation.

During Targeting Mitochondria 2016, Pr Franck Norbert Gellerich from Otto-von-Guericke University, Germany will present the tissue specificity of mitochondrial energy metabolism.

More information about the program, speakers and registration: www.targeting-mitochondria.com

 

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