World Mitochondria Society awarded Nanolive for their New Technology in the Visualisation of Mitochondria
World Mitochondria Society is honored to award Nanolive for their new technology, the Holotomographic Phase Imaging or Short Nanolive Imaging, presented during Targeting Mitochondria 2019, which was held in Berlin, Germany.
The Nanolive Imaging allows the visualization of Mitochondria without any staining or labeling, it requires ~ 100 times less energy than light-sheet microscopes. Moreover, with a resolution below 200 nm, it enables high resolution and high-frequency imaging even with sensitive material, giving access to organelle dynamics that were previously out of reach.
The Scientific Committee would like to thank Dr. Jamin Jung for his excellent talk on the non-invasive live cell imaging overcomes phototoxicity problem while imaging cellular and mitochondrial processes, presented during Targeting Mitochondria 2019.
Testimonial of Marlies Muernseer, Field Application Specialist, from Nanolive:
"The Targeting Mitochondria Conference 2019 was an excellent venue and allowed us to interact with scientists from around the world and discuss Nanolive’s imaging techniques to image mitochondria fine dynamics. The large amount of interesting talks covered the whole field and gave deep insights into upcoming and unpublished facets of cutting-edge research. We want to thank for the excellent organisation and venue."
For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com
The Poster Contribution Award was delivered to Prof. Bing Xu
During the Targeting Mitochondria 2019 congress, which was held in Berlin, Germany, the Scientific Committee awarded Prof. Bing Xu, from Brandeis University, USA, for his Poster Contribution entitled "Enzyme-instructed self-assembly for selectively transfecting the mitochondria of cancer cells"
The research work presented by his poster contribution offers a versatile and robust strategy for transfecting mammalian mitochondria and understanding mitochondrial cancer biology, illustrating spatiotemporal control of noncovalent (or supramolecular) interactions for regulating functions in different cell.
Testimonial of Prof. Xu:
" I am a chemist who has a lab working on enzyme-instructed self-assembly (EISA) for cancer therapy. Because our results unexpected lead to mitochondria targeting, I came to 10th Targeting Mitochondria Congress to learn from the pioneers and leading experts in the field of mitochondria targeting. This meeting mixed the talks of leading experts in academia, clinics, and industries highlighted the cutting-edge progress. The short presentations also provided a comprehensive range of research activities. The poster sessions are well-organized and informative. I have learned so much from these two day’s meeting, which is what I expected. But the poster award to us is unexpected. I am very grateful for the encouragement by the meeting organizing committee. The credit should go to my PhD student, Mr. Hongjian He, who did all the work"
For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com
Novel movies showing lipid droplets and mitochondria fine dynamics live and at high resolution
Thanks to the 3D Cell Explorer’s live imaging capabilities, highlights of lipid droplets and mitochondria fine dynamics that were previously out of reach are clearly visible now.
On the top panel you can observe a time-lapse video of of pre-adipocytes imaged with the 3D Cell Explorer for 1 hour at a frequency of one image per five seconds (movie speed: 15fps). On the middle panel are displayed four time point images of a mitochondrial fission happening in the cell. On the bottom panel a fusion process is displayed.
During the Targeting Mitochondria 2019 Congress, Holotomographic Phase Imaging or short Nanolive Imaging will be presented at the Targeting Mitochondria with a talk and booth.
Non-invasive live cell imaging overcomes phototoxicity problem while imaging cellular and mitochondrial processes
Mitochondria are key organelles for various essential cellular processes.
A better understanding of the dynamics and interactions with other organelles could benefit research as well as future therapeutic approaches. The Targeting Mitochondria 2019 will host a broad spectrum of speakers advancing our common scientific field. The introduction of a new technology for label free gentle live cell imaging of Mitochondria might add an important new instrument to this advancement. Holotomographic Phase Imaging or short Nanolive Imaging will be presented at the Targeting Mitochondria with a talk and booth.
A major problem with current imaging techniques is phototoxicity that leads to the observation of perturbed dynamics. Consequently, the mitigation of phototoxicity leads to poor time resolution of time lapse approaches. This is particularly true for small organelles like mitochondria or lipid droplets that are extremely sensitive to photo-induced oxidation. Last but not least, the use of chemical or genetically-encoded fluorescent markers perturbs the targeted biological processes.
However, the Nanolive Imaging allows visualisation of Mitochondria without any staining or labelling. Further, it requireds ~100 times less energy (~0.2 nW/µm2) than light sheet microscopes (~1nW/µm2). With a resolution below 200 nm, it enables high resolution and high-frequency imaging even with sensitive material, giving access to organelle dynamics that were previously out of reach.
Please follow this link to Watch the video.
10th Anniversary of Targeting Mitochondria Congress
October 28-29, 2019 - Berlin, Germany
www.mitochondria-site.com
Symposium Actin(g) on mitochondria: The role of actin-regulating proteins on mitochondria in health and disease
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Introduction: Role of actin-regulating proteins on mitochondria |
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Role of Mitochondria in Ferroptosis Mitochondrial Functions of The Actin-Regulatory Protein Cofilin1 Cofilin Dependent Mitochondrial Dysfunction Following Hemorrhagic Brain Injury and Neuroinflammation Mitochondrial Pathways in Neuronal Cell Death Knock-down of ADF/Cofilin in C. Elegans - Effects on Mitochondrial Function
Mitochondrial Parameters in Cardiomyocytes in Health and Disease Mitochondrial Calcium Regulation in Hypertensive Heart Disease
Mitochondrial Alterations in Heart Failure
Blocking Mitochondria-targeted Ferroptosis Prevents Cardiomyopathy |
10th Anniversary of Targeting Mitochondria Congress
October 28-29, 2019 - Berlin, Germany
Cytoskeletal mitochondrial interactions in collagen VI related disorders
The Scientific Committee of WMS is honored to announce that Dr. Alessia Angelin from Children's Hospital of Philadelphia, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
During the Congress Dr. Angelin will speak about "Cytoskeletal mitochondrial interactions in collagen VI related disorders".
Summary of presentation:"Mitochondria are prominent players in cell energy conversion, integrated signaling pathways, calcium homeostasis and regulation of apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport to specialized cellular sites. This transport occurs through interactions with a variety of cytoskeletal proteins that also influence shape and function of this organelle. Our study focuses on the correlation between mitochondrial function and cytoskeleton structure. We found that improper cytoskeleton filament organization appears to connect the altered extracellular matrix with the mitochondrial dysfunction in collagen VI related disorders, and thus may present a new target for pharmacological therapy of these disorders and other human muscular dystrophies".
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Microbiota-Mitochondria Intertalk: A Dedicated session
During the Targeting Mitochondria, a session will be chaired by Prof. Marvin Edeas, University Paris Descartes, INSERM U1016, France, concerning the hot topics 2019: Microbiota-Mitochondria Intertalk.
Two Talks will be presented during this dedicated session:
Mitochondria & Microbiota Inter-talk: Gut Microbiota inflence Mitochondria activity in patients
Marvin Edeas, University Paris Descartes, INSERM U1016, France
Host mitochondria influence gut microbiome diversity: A role for ROS
Tal Yardeni, Children's Hospital of Philadelphia, USA
Summary of Dr. Yardeni's presentation: "Changes in the gut microbiome are linked with the same diseases as those caused by changes in the mitochondrial genome. To investigate why, we tested the gut microbiome community of our mitochondrial mouse models. These studies reveal that the host mitochondrial ROS production influences the gut microbiome community. Our data suggest that mitochondrial function modulates both ROS production and the microbiome, implying that the connection between the gut microbiome and common disease might be due to changes in mitochondrial function."
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
2,4-Dinitrophenol as Medicine
The Scientific Committee of Targeting Mitochondria 2019 congress invited Dr. John G. Geisler from Mitochon Pharmaceuticals, Inc, USA to talk about his research on "2,4-Dinitrophenol as Medicine" during the 10th Anniversary of Targeting Mitochondria Congress, which will be held in Berlin, Germany, on October 27th – 29th, 2019.
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Targeting Mitochondria 2019 Congress will be held Hotel InterContinental
Budapester Straße 2, 10787 Berlin, Germany
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Hotel Booking with preferential rate is closed after October 7th.
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Please be careful: if some third-party company contacts you Hotel booking & Transport and asks about your Credit card information.
Please book your Hotel only using the special link below!
We do not have any representatives or Travel Agency. If anyone contacts you, it is not related to Targeting Mitochondria 2019 Congress.
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Special Rate for Room Booking at Intercontinental Berlin Hotel
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The upscale InterContinental® Berlin hotel sits next to leafy Tiergarten Park, pleasant walk from the iconic Brandenburg Gate. Choose an elegant room or spacious suite, swim in the inviting indoor pool and indulge in a treatment at SPA InterContinental. Entertaining clients in style on a dedicated meeting floor or making an impression with a function in the ballroom. After work, sip cocktails in the Marlene Bar and experience gourmet dining in a chic 14th-floor restaurant with panoramic city views. Targeting Mitochondria Committee offers to the congress attendees a special privileged rate for your booki: |
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The challenge of qualitative and quantitative assessment of mitochondrial function
Dr. Egbert Mik will overview the perspective related to Mitochondria Evaluation in vitro, in vivo and human
Dr. Egbert Mik from the Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019
Dr. Mik will present the last methods (qualitative and quantitative assessment of mitochondrial function) and What we know in 2019 ?
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Mitochondrial Copper Toxicity with a Focus on Wilson Disease
Prof. Hans Zischka from Institute of Molecular Toxicology and Pharmacology, Germany will present his team's research during the congress and will give a talk entitled "Mitochondrial Copper Toxicity with a Focus on Wilson Disease".
Summary of Talk: Wilson disease (WD) is a hereditary defect in the metabolism of copper. Here, the liver is unable to eliminate excess copper causing its accumulation primarily in liver and brain. In neurons and hepatocytes, a rising copper overload particularly damages their mitochondria. However, sometimes years pass before cell death occurs, suggesting the possible existence of intracellular protective mechanisms that can counteract such mitochondrial poisoning.
Therefore, we examined cell cultures from WD patients but also WD rodent models for their reaction to copper. We observed that the hepatocytes reacted to copper overload with an intensification of the mechanisms that support autophagy. Particularly, the copper-overloaded mitochondria are affected by this process (in this case called mitophagy). However, mitophagy helps only up to a certain level of copper overload and other treatments need to be employed to avoid cell death. Nevertheless, these results demonstrate the potential for cell regeneration resulting from auto-/mitophagy, which could also be relevant for other disorders that arise or are paralleled by cell-toxic metal accumulations.
For more information: https://targeting-mitochondria.com
Mitochondria, as central regulators of neural stem cell fate
The Scientific Committee of WMS is honored to announce that Dr. Ruth Slacks from University of Ottawa, Canada will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
Dr. Slacks will give a presentation entitled "Mitochondria, as central regulators of neural stem cell fate".
For more information: https://targeting-mitochondria.com
The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain
Dr. Laurent Chatre will introduce "The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain".
Dr. Laurent Chatre from CNRS, the University of Caen-Normandie, France will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
Summary of presentation: From brain functions to brain hypoxia, ischemia, inflammation and cancer, Dr. Chatre will discuss their starting brain MITOxy project positioningt he coordination between mitochondria, proteases including serine proteases and the reactive species interactome (RSI)as the key regulator involved in normal and pathological conditions, and to control in the future.
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Mitochondrial Antioxidant Therapy for Treating Vascular Aging
Prof. Seals will give a strategic talk on "Mitochondrial Antioxidant Therapy for Treating Vascular Aging".
The Scientific Committee of Targeting Mitochondria 2019 Congress is honored to announce Prof. Douglas R Seals from University of Colorado Boulder, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
Summary of the Talk: Arterial dysfunction is the major risk factor driving the dramatic increase in risk of cardiovascular diseases with aging. Excessive superoxide production by mitochondria is a key mechanism underlying age-related vascular dysfunction and, as such, is a major therapeutic target for prevention of cardiovascular disorders. I will discuss our translational research efforts to establish the efficacy of the mitochondrial antioxidant, MitoQ, for the treatment of arterial dysfunction with aging.
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Increased Hydrogen Peroxide and Decreased Glutathione Redox Potential May Cause Dopaminergic Neurodegeneration in Parkin Loss-of-Function Drosophila
The Scientific Committee of WMS is honored to announce that Dr. Lori Buhlman, Associate Professor from the College of Graduate Studies of Midwestern University, USA, will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
In her presentation entitled "Increased Hydrogen Peroxide and Decreased Glutathione Redox Potential May Cause Dopaminergic Neurodegeneration in Parkin Loss-of-Function Drosophila", Dr. Buhlman will discuss with us her recent studies on the mechanism of selective neurodegeneration in familial Parkinson’s disease. They use parkin loss-of-function Drosophila, which have selective dopaminergic neurodegeneration and motor behavior deficits. "We have observed that degenerating neurons have transiently decreased mitophagy initiation, disrupted mitochondrial dynamics and increased mitochondrial protein oxidation, none of which were detected in non-degenerating dopaminergic neurons. Current goals are to understand important differences between vulnerable and non-degenerating dopaminergic degeneration in adult and developing flies and use genetic and pharmacological interventions to address them."
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
The cellular stress protein MNRR1/CHCHD2 and mitochondrial disease
Prof. Lawrence Grossman from Wayne State University, USA will join the Targeting Mitochondria 2019 congress and will give a talk entitled "The cellular stress protein MNRR1/CHCHD2 and mitochondrial disease".
Summary of talk: MNRR1 is a key mitochondrial stress regulator with the novel property of functioning in both the nucleus and the mitochondria yet having a different function in each organelle. Because cellular depletion of MNRR1 results in a phenocopy of some mitochondrial diseases, we investigated whether manipulating MNRR1 expression could reverse the cellular defects associated with them. Notably, in a model of the mitochondrial disease MELAS we could restore abnormal cellular functions by forced expression of MNRR1 or by its activation.
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
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- Role of actin-regulating proteins on mitochondria - Introduction by Prof. Cartrsten Culmsee
- Mitochondria and Skin: A dedicated session during Targeting Mitochondria 2019
