Presentation of the mitochondrial DNA damaged induced inflammation in lung epithelial cells

Bartosz Szczesny Targeting Mitochondria

Dr Bartosz Szczesny, Associate Professor at the Department of Anesthesiology of the University of Texas Medical Branch at Galveston, USA is invited during Targeting Mitochondria World Congress is to give a presentation about the mitochondrial DNA damaged induced inflammation in lung epithelial cells.

According to Dr Szczesny: "Pulmonary epithelial cells are key effectors and targets in the pathogenesis of inflammatory lung diseases such as asthma, and chronic obstructive pulmonary disease, among others. Oxidative stress has been implicated at the earliest step in development of lung inflammation, but the molecular mechanisms of how oxidantive injury to epithelial cells develops inflammatory response remain unclear. While investigating the mechanisms responsible for activating inflammation in response to prolonged, low-level oxidative stress, we identified a role for an active and selective cellular extrusion of damaged mitochondrial DNA, that did not affect cellular viability. Selective release of damaged mitochondrial DNA, first into the cytoplasm and subsequently into the extracellular space, triggers autocrine and paracrine modes of the inflammatory response. I will be discussing cellular outcomes and inflammatory signaling pathways in response to mitochondrial DNA-specific damage in cell culture and in vivo models."

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