Symposium Actin(g) on mitochondria: The role of actin-regulating proteins on mitochondria in health and disease
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Introduction: Role of actin-regulating proteins on mitochondria |
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Role of Mitochondria in Ferroptosis Mitochondrial Functions of The Actin-Regulatory Protein Cofilin1 Cofilin Dependent Mitochondrial Dysfunction Following Hemorrhagic Brain Injury and Neuroinflammation Mitochondrial Pathways in Neuronal Cell Death Knock-down of ADF/Cofilin in C. Elegans - Effects on Mitochondrial Function
Mitochondrial Parameters in Cardiomyocytes in Health and Disease Mitochondrial Calcium Regulation in Hypertensive Heart Disease
Mitochondrial Alterations in Heart Failure
Blocking Mitochondria-targeted Ferroptosis Prevents Cardiomyopathy |
10th Anniversary of Targeting Mitochondria Congress
October 28-29, 2019 - Berlin, Germany
Novel movies showing lipid droplets and mitochondria fine dynamics live and at high resolution
Thanks to the 3D Cell Explorer’s live imaging capabilities, highlights of lipid droplets and mitochondria fine dynamics that were previously out of reach are clearly visible now.
On the top panel you can observe a time-lapse video of of pre-adipocytes imaged with the 3D Cell Explorer for 1 hour at a frequency of one image per five seconds (movie speed: 15fps). On the middle panel are displayed four time point images of a mitochondrial fission happening in the cell. On the bottom panel a fusion process is displayed.
During the Targeting Mitochondria 2019 Congress, Holotomographic Phase Imaging or short Nanolive Imaging will be presented at the Targeting Mitochondria with a talk and booth.
Non-invasive live cell imaging overcomes phototoxicity problem while imaging cellular and mitochondrial processes
Mitochondria are key organelles for various essential cellular processes.
A better understanding of the dynamics and interactions with other organelles could benefit research as well as future therapeutic approaches. The Targeting Mitochondria 2019 will host a broad spectrum of speakers advancing our common scientific field. The introduction of a new technology for label free gentle live cell imaging of Mitochondria might add an important new instrument to this advancement. Holotomographic Phase Imaging or short Nanolive Imaging will be presented at the Targeting Mitochondria with a talk and booth.
A major problem with current imaging techniques is phototoxicity that leads to the observation of perturbed dynamics. Consequently, the mitigation of phototoxicity leads to poor time resolution of time lapse approaches. This is particularly true for small organelles like mitochondria or lipid droplets that are extremely sensitive to photo-induced oxidation. Last but not least, the use of chemical or genetically-encoded fluorescent markers perturbs the targeted biological processes.
However, the Nanolive Imaging allows visualisation of Mitochondria without any staining or labelling. Further, it requireds ~100 times less energy (~0.2 nW/µm2) than light sheet microscopes (~1nW/µm2). With a resolution below 200 nm, it enables high resolution and high-frequency imaging even with sensitive material, giving access to organelle dynamics that were previously out of reach.
Please follow this link to Watch the video.
10th Anniversary of Targeting Mitochondria Congress
October 28-29, 2019 - Berlin, Germany
www.mitochondria-site.com
The Poster Contribution Award was delivered to Prof. Bing Xu
During the Targeting Mitochondria 2019 congress, which was held in Berlin, Germany, the Scientific Committee awarded Prof. Bing Xu, from Brandeis University, USA, for his Poster Contribution entitled "Enzyme-instructed self-assembly for selectively transfecting the mitochondria of cancer cells"
The research work presented by his poster contribution offers a versatile and robust strategy for transfecting mammalian mitochondria and understanding mitochondrial cancer biology, illustrating spatiotemporal control of noncovalent (or supramolecular) interactions for regulating functions in different cell.
Testimonial of Prof. Xu:
" I am a chemist who has a lab working on enzyme-instructed self-assembly (EISA) for cancer therapy. Because our results unexpected lead to mitochondria targeting, I came to 10th Targeting Mitochondria Congress to learn from the pioneers and leading experts in the field of mitochondria targeting. This meeting mixed the talks of leading experts in academia, clinics, and industries highlighted the cutting-edge progress. The short presentations also provided a comprehensive range of research activities. The poster sessions are well-organized and informative. I have learned so much from these two day’s meeting, which is what I expected. But the poster award to us is unexpected. I am very grateful for the encouragement by the meeting organizing committee. The credit should go to my PhD student, Mr. Hongjian He, who did all the work"
For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com
World Mitochondria Society awarded Nanolive for their New Technology in the Visualisation of Mitochondria
World Mitochondria Society is honored to award Nanolive for their new technology, the Holotomographic Phase Imaging or Short Nanolive Imaging, presented during Targeting Mitochondria 2019, which was held in Berlin, Germany.
The Nanolive Imaging allows the visualization of Mitochondria without any staining or labeling, it requires ~ 100 times less energy than light-sheet microscopes. Moreover, with a resolution below 200 nm, it enables high resolution and high-frequency imaging even with sensitive material, giving access to organelle dynamics that were previously out of reach.
The Scientific Committee would like to thank Dr. Jamin Jung for his excellent talk on the non-invasive live cell imaging overcomes phototoxicity problem while imaging cellular and mitochondrial processes, presented during Targeting Mitochondria 2019.
Testimonial of Marlies Muernseer, Field Application Specialist, from Nanolive:
"The Targeting Mitochondria Conference 2019 was an excellent venue and allowed us to interact with scientists from around the world and discuss Nanolive’s imaging techniques to image mitochondria fine dynamics. The large amount of interesting talks covered the whole field and gave deep insights into upcoming and unpublished facets of cutting-edge research. We want to thank for the excellent organisation and venue."
For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com
KLOX Technologies Inc. awarded during Targeting Mitochondria 2019
During Targeting Mitochondria 2019, KLOX Technologies Inc. have received the Innovation Award for their study on the assessment of the effect of Fluorescent Light Energy (FLE) on mitochondria dynamics.
The Scientific Committee thanks KLOX Technologies Inc. for their talk entitled "Effects of fluorescent light energy on mitochondria dynamics" presented during Targeting Mitochondria 2019. Their study showed that FLE decreased total mitochondria number and increased single mitochondria volume, likely due to fusion events that reversed "small sphere" mitochondria and restored the mitochondria network (morphology) to a complex, branched network.
Testimonial of Dr. Michela Zago, Manager and Senior Research Associate of KLOX Technologies Inc.:
"Our team at Klox Technologies was particularly excited about attending this Congress as its focus is well in line with our effort to target distressed mitochondria using our Fluorescent Light Energy Biomodulation technology. Klox was impressed by the quality of the speakers and the depth of the topics as well as humbled by the receipt of the 2019 Innovation Award"
For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com
World Mitochondria Society awarded Minovia during Targeting Mitochondria 2019
The Scientific Committee of Targeting Mitochondria 2019 is honored to discern the Innovation Award to Minovia for their clinical study on the Mitochondria Augmentation Therapy.
The study performed by Minovia and presented during Targeting Mitochondria 2019 "Mitochondria augmentation therapy (MAT): mitochondrial enrichment of hematopoietic stem cells in patients with mitochondrial disease", suggest that MAT can diminish disease progression in patients with mtDNA disorders.
For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com
World Mitochondria Society would like to thank Biolog
World Mitochondria Society Team would like to thank Biolog for their support and participation during Targeting Mitochondria 2019, which was held in Berlin, Germany in October.
Biolog had a booth during the two days of conference, and a talk presented by Dr. Barry R. Bochner from Biolog on their news assays plates, the MitoPlate I-1TM, which has a triplicate repeat of 30 energy producing substrates and the MitoPlate S-1TM, which has 22 inhibitors of mitochondrial function titrated at 4 dilutions. Using these new assays Dr. Bochner shows that mitochondria from different cell types exhibit different functional properties.
For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com
The organizers of Targeting Mitochondria 2019 would like to thank MitoQ
The organizers thank MitoQ for their support and participation at the Targeting Mitochondria 2019.
MitoQ also supports the presentation of Prof. Douglas Seals, from the University of Colorado Boulder, USA, on the mitochondria antioxidant therapy for treating vascular aging.
For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com
