The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain
Dr. Laurent Chatre will introduce "The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain".
Dr. Laurent Chatre from CNRS, the University of Caen-Normandie, France will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
Summary of presentation: From brain functions to brain hypoxia, ischemia, inflammation and cancer, Dr. Chatre will discuss their starting brain MITOxy project positioningt he coordination between mitochondria, proteases including serine proteases and the reactive species interactome (RSI)as the key regulator involved in normal and pathological conditions, and to control in the future.
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Mitochondria, as central regulators of neural stem cell fate
The Scientific Committee of WMS is honored to announce that Dr. Ruth Slacks from University of Ottawa, Canada will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
Dr. Slacks will give a presentation entitled "Mitochondria, as central regulators of neural stem cell fate".
For more information: https://targeting-mitochondria.com
Mitochondrial Copper Toxicity with a Focus on Wilson Disease
Prof. Hans Zischka from Institute of Molecular Toxicology and Pharmacology, Germany will present his team's research during the congress and will give a talk entitled "Mitochondrial Copper Toxicity with a Focus on Wilson Disease".
Summary of Talk: Wilson disease (WD) is a hereditary defect in the metabolism of copper. Here, the liver is unable to eliminate excess copper causing its accumulation primarily in liver and brain. In neurons and hepatocytes, a rising copper overload particularly damages their mitochondria. However, sometimes years pass before cell death occurs, suggesting the possible existence of intracellular protective mechanisms that can counteract such mitochondrial poisoning.
Therefore, we examined cell cultures from WD patients but also WD rodent models for their reaction to copper. We observed that the hepatocytes reacted to copper overload with an intensification of the mechanisms that support autophagy. Particularly, the copper-overloaded mitochondria are affected by this process (in this case called mitophagy). However, mitophagy helps only up to a certain level of copper overload and other treatments need to be employed to avoid cell death. Nevertheless, these results demonstrate the potential for cell regeneration resulting from auto-/mitophagy, which could also be relevant for other disorders that arise or are paralleled by cell-toxic metal accumulations.
For more information: https://targeting-mitochondria.com
The challenge of qualitative and quantitative assessment of mitochondrial function
Dr. Egbert Mik will overview the perspective related to Mitochondria Evaluation in vitro, in vivo and human
Dr. Egbert Mik from the Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019
Dr. Mik will present the last methods (qualitative and quantitative assessment of mitochondrial function) and What we know in 2019 ?
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Targeting Mitochondria 2019 Congress will be held Hotel InterContinental
Budapester Straße 2, 10787 Berlin, Germany
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Special Rate for Room Booking at Intercontinental Berlin Hotel
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The upscale InterContinental® Berlin hotel sits next to leafy Tiergarten Park, pleasant walk from the iconic Brandenburg Gate. Choose an elegant room or spacious suite, swim in the inviting indoor pool and indulge in a treatment at SPA InterContinental. Entertaining clients in style on a dedicated meeting floor or making an impression with a function in the ballroom. After work, sip cocktails in the Marlene Bar and experience gourmet dining in a chic 14th-floor restaurant with panoramic city views. Targeting Mitochondria Committee offers to the congress attendees a special privileged rate for your booki: |
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2,4-Dinitrophenol as Medicine
The Scientific Committee of Targeting Mitochondria 2019 congress invited Dr. John G. Geisler from Mitochon Pharmaceuticals, Inc, USA to talk about his research on "2,4-Dinitrophenol as Medicine" during the 10th Anniversary of Targeting Mitochondria Congress, which will be held in Berlin, Germany, on October 27th – 29th, 2019.
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Microbiota-Mitochondria Intertalk: A Dedicated session
During the Targeting Mitochondria, a session will be chaired by Prof. Marvin Edeas, University Paris Descartes, INSERM U1016, France, concerning the hot topics 2019: Microbiota-Mitochondria Intertalk.
Two Talks will be presented during this dedicated session:
Mitochondria & Microbiota Inter-talk: Gut Microbiota inflence Mitochondria activity in patients
Marvin Edeas, University Paris Descartes, INSERM U1016, France
Host mitochondria influence gut microbiome diversity: A role for ROS
Tal Yardeni, Children's Hospital of Philadelphia, USA
Summary of Dr. Yardeni's presentation: "Changes in the gut microbiome are linked with the same diseases as those caused by changes in the mitochondrial genome. To investigate why, we tested the gut microbiome community of our mitochondrial mouse models. These studies reveal that the host mitochondrial ROS production influences the gut microbiome community. Our data suggest that mitochondrial function modulates both ROS production and the microbiome, implying that the connection between the gut microbiome and common disease might be due to changes in mitochondrial function."
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Cytoskeletal mitochondrial interactions in collagen VI related disorders
The Scientific Committee of WMS is honored to announce that Dr. Alessia Angelin from Children's Hospital of Philadelphia, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
During the Congress Dr. Angelin will speak about "Cytoskeletal mitochondrial interactions in collagen VI related disorders".
Summary of presentation:"Mitochondria are prominent players in cell energy conversion, integrated signaling pathways, calcium homeostasis and regulation of apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport to specialized cellular sites. This transport occurs through interactions with a variety of cytoskeletal proteins that also influence shape and function of this organelle. Our study focuses on the correlation between mitochondrial function and cytoskeleton structure. We found that improper cytoskeleton filament organization appears to connect the altered extracellular matrix with the mitochondrial dysfunction in collagen VI related disorders, and thus may present a new target for pharmacological therapy of these disorders and other human muscular dystrophies".
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
