Foxp3 increases oxidative phosphorylation and Nad oxidation, adapting regulatory T cells to low glucose high lactate environments
Dr. Alessia Angelin from Children's Hospital of Philadelphia, Philadelphia, USA will give presentation about "Foxp3 increases oxidative phosphorylation and Nad oxidation, adapting regulatory T cells to low glucose high lactate environments" during the 9th World Congress on Targeting Mitochondria, which will be held at Steigenberger Hotel, Berlin on October 23-25, 2018.
Dr. Alessia Angelin highlights her research as: "T-regulatory (Treg) cells maintain peripheral tolerance and prevent autoimmunity, but their immune suppressive properties can also work to a disadvantage in the tumor microenvironment. Solid tumors can be depleted of glucose and enriched with lactic acid. This can weaken anti-tumor immunity, as cytotoxic and effector T cells require glycolysis to proliferate and produce cytokines."
For more information about Targeting Mitochondria 2018, www.targeting-mitochondria.com
Mitochondrial involvement in cell life/death regulation: Presentation of new scientific results
Prof. Vladimir Gogvadze from from Karolinska Institute, Sweden will give talk entitled "Mitochondrial involvement in cell life/death regulation: Presentation of new scientific results" during the next 9th World Congress on Targeting Mitochondria on October 23-25, 2018, which will be held at Steingenberger Hotel, in Berlin, Germany
Prof. Vladimir Gogvadze summarized his presentation as:
Mitochondria are to a great extent engaged in the modulation of cell viability and death. The involvement of mitochondria in the etiology of various diseases has been confirmed repeatedly, and new data have been obtained on the possibility of combating various pathologies by targeting these organelles. Mitochondria not only regulate various cell death modalities, but also control a crosstalk between them. Precise mechanisms of this crosstalk regulation are still poorly understood. Uncovering the role of mitochondria in the regulation of the crosstalk between various forms of cell death will help to develop new therapeutic strategies in fighting cancer, hematological, neurodegenerative and autoimmune disorders.
For more information about Targeting Mitochondria 2018, please visit www.targeting-mitochondria.com
Targeting Mitochondria 2018
October 23-25, 2018 - Berlin, Germany
What are the molecular consequences of OXPHOS dysfunction?
Dr. Inge Kühl from the CNRS - Institut de Biologie Intégrative de la Cellule (I2BC), Gif-sur-Yvette, France will give a strategic presentation about “The transcriptomic and proteomic landscape of mitochondrial dysfunction in mouse” during the next 9th World Congress on Targeting Mitochondria, which will be held at Steigenberger Hotel, Berlin on October 23-25, 2018.
According to Dr. Inge Kühl: "Dysfunction of the oxidative phosphorylation (OXPHOS) system is a major cause of human disease and the cellular consequences are highly complex. We did comparative analyses of mitochondrial proteomes, cellular transcriptomes and targeted metabolomics of five knockout mouse strains deficient in essential factors required for mitochondrial DNA gene expression, leading to OXPHOS dysfunction. Moreover, we describe sequential protein changes during post-natal development and progressive OXPHOS dysfunction in time-course analyses in control mice and a middle lifespan knockout, respectively. Our extensive omics analyses provide a high-quality resource of altered gene expression patterns under severe OXPHOS deficiency comparing several mouse models, that will deepen our understanding, open avenues for research and provide an important reference for diagnosis and treatment."
For more information about Targeting Mitochondria 2018, please visit www.targeting-mitochondria.com
Targeting Mitochondria Pratical Information, Final Agenda and Abstracts Book
Hotel Booking:
If you wish to book a room at Steigenberger Hotel, please follow this link for more info or contact us
We will update you with more practical information soon.
Mitochondria-targeted Nanocarriers for mitochondrial therapies
The Scientific Committee of WMS is honored to announce that Prof. Shanta Dhar, Associate Professor from Department of Biochemistry and Molecular Biology at the University of Miami, USA, will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019 and will speak about "Mitochondria-targeted Nanocarriers for mitochondrial therapies".
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
Call for Abstracts & Innovations
The Scientific Committee of the World Mitochondria Society & Targeting Mitochondria World Congress 2019 are pleased to invite all scientists, academics and industrials to present their researches in all mitochondria-related fields during the 10th World Congress on Targeting Mitochondria, which will be held in Berlin, on October 28th-29th, 2019.
We remind you the key dates of this international meeting:
- Deadline for Short Oral Presentations Submission: October 5, 2019
- Deadline for Poster Presentations Submission: October 15, 2019
To access to all information about abstracts submission, please click here.
For all information about Targeting Mitochondria 2019: www.targeting-mitochondria.com
Selective segregation of mitochondria in asymmetric stem cell divisions
The Scientific Committee of WMS is honored to announce that Assoc. Prof. Pekka Katajisto, Associate Professor in Karolinska Institutet and University of Helsinki, Finland, as well as Director of the Center of Excellence in Stem Cell Metabolism, will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.
In his presentation entitled "Selective segregation of mitochondria in asymmetric stem cell divisions", Dr. Pekka Katajisto will share with us his studies that could be introduced as such: "Tissue resident stem cells renew and repair our tissues. However, in order to secure tissue homeostasis, generation of new stem cells via self-renewal and their differentiation in to functional cells must be carefully balanced. During aging, multiple types of alterations directly in stem cells, or in their tissue neighbourhood can disturb this balance. Our laboratory studies both stem cell intrinsic, and extrinsic mechanisms altering tissue renewal capacity."
For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com
