Creation of a designer molecule to target and silence mitochondrial gene transcription
Dr. Ganesh Pandian Namasivayam from Kyoto University, Japan will present his research on "Creation of a designer molecule to target and silence mitochondrial gene transcription'' during Targeting Mitochondria 2018 congress.
According to Dr Namasivayam: "Harnessing the sequence information about the mitochondrial gene transcription, we created a synthetic designer molecule termed MITO-PIP that can selectively localize inside mitochondrion and recognize the target DNA sequence. MITO-PIP triggered targeted transcriptional suppression in HeLa cells by inhibiting the mitochondrial transcription factor A to the light-strand promoter. Currently, we are advancing our designer molecule to gain control over mitochondrial gene expression."
For more information, please visit www.targeting-mitochondria.com
How to regulate cardiac excitation-contraction-bioenergetics coupling by mitochondrial fission protein Drp1?
"Studies have shown that Drp1 is abundantly expressed in adult cardiac myocytes. Paradoxically, compared to numerous cell types, adult cardiac myocytes exhibit very low frequency in mitochondrial fission. In this presentation, I will describe the mechanisms of non-canonical (fission-independent) roles of Drp1 in regulating cardiac bioenergetics during the heartbeats."
Prof Shey-Shing Sheu from Thomas Jefferson University, USA will talk about the regulation of cardiac excitation-contraction-bioenergetics during Targeting Mitochondria 2017 world congress which will be held in Berlin, Germany.
More information: www.targeting-mitochondria.com
Targeting mitochondria by small RNAs: update and prospects
Mitochondria import a variety of macromolecules encoded in nuclear DNA and addressed in the organelle via complex targeting and translocation mechanisms. Among these small non-coding RNA are of particular interest since they are the unique natural pathway to deliver nucleic acids in mitochondria, and can therefore be exploited to address pathogenic mtDNA mutations. So far, neither the extent of its expansion, nor the precise molecular mechnism of this targeting is fully understood. In this talk, Dr. Ivan Tarassov from the University of Strasbourg, France will expose new data on the variety of mitochondrially imported RNA in human cells and discuss new possible strategies exploiting this pathway.
This talk will be presented during the 8th World Congress on Targeting Mitochondria 2017.
More information: www.targeting-mitochondria.com
Hydrogen sulfide and mitochondrial function: Presentation of the scientific advances
During the 8th World Congress on Targeting Mitochondria 2017, Dr. Csaba Szabo from University of Texas, USA will present his work on "Hydrogen sulfide and mitochondrial function".
According to him: "H2S has emerged over the last decade as an important, endogenously produced biological mediator. Inhibition of cytochrome C oxidase is the longest known mitochondrial effect of H2S. However, work of recent years showed that H2S, at lower concentrations, acts as an electron donor to the mitochondria, and serves as an inorganic substrate for mitochondrial electron transport. Additional mitochondrial effects of H2S include the stimulation of mitochondrial electron transport via inhibition of mitochondrial phosphodiesterase 2A, and activation of Complex V via sulfhydration. In some disease conditions (e.g. ischemia, vascular disease, diabetic complications), H2S levels are decreasing and H2S donation can exert therapeutic effects. In other conditions, the idea that H2S can be used to induce an on-demand metabolic suppression ("hibernation") has been proposed. In yet other conditions (e.g. inflammation, septic shock, burn injury and certain forms of cancer), H2S overproduction occurs and H2S biosynthesis inhibitors may be a therapeutic approach of the future. The talk will overview the various mitochondrial actions of H2S and will highlight some of the physiological, pathophysiological and therapeutic implications of these processes."
More information: www.targeting-mitochondria.com
Quantifying mitochondrial uptake of nucleobase derivatives through click chemistry
Recently, there has been an increased interest in delivering large molecules to the mitochondrial matrix. However, determining uptake into the mitochondrial matrix is not a straightforward matter. In this talk, Dr. Kurt Hoogewijs from The Wellcome Trust Centre for Mitochondrial Research, Newcastle University, United Kingdom. will describe a novel strategy for the quantification of mitochondrial uptake, based on the quantification of an in situ formed click product.
This study will be presented during the 8th World Congress on Targeting Mitochondria 2017.
More information: www.targeting-mitochondria.com
Mitochondrial ROS mediated signaling pathways: activation and regulation upon inflammation
Dr. Andrey V. Kozlov from Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (Vienna, Austria) will talk at the 8th Targeting Mitochondria World congress on “Mitochondrial ROS mediated signaling pathways: activation and regulation upon inflammation”.
“In the past, reactive oxygen species (ROS) were considered as side products of cellular metabolism causing oxidative damage to diverse biomolecules and biomembranes. More recently ROS have been discovered as an important component of intracellular signaling cascades. Moreover, recent reports suggest that mitochondrial ROS are the most critical ROS in the activation of specific intracellular signaling cascades. The analysis of diseases associated with inflammation suggests that the activation of mitochondrial ROS mediated signaling cascades can be deleterious causing organ dysfunction.”
More information: www.targeting-mitochondria.com
“The Human Longevity Project - Part 1" will be projected during Targeting Mitochondria World Congress
The Human Longevity Project (Part 1) to be screened at the Targeting Mitochondria 2017 Congress is the world premiere of a groundbreaking, new documentary film series that takes an exciting journey around the globe to study the planet’s healthiest centenarians. This upcoming documentary film opens a new investigation into the four Blue Zones around the world, which have been previously identified by Michel Poulain and National Geographic as places containing an inordinate concentration of people with exceptionally long health-spans and incredible levels of vitality late in life. The Human Longevity Project is an 8-part film series that includes interviews from premier scientists, physicians, healers, & health experts around the globe and gathers together real-world footage and interviews with individuals in the Blue Zones. The intent is to reexamine the daily routines and practices ranging the entire lifespan to determine, from a bioenergetic standpoint, precisely how lifestyle factors affect the aging process and how we can adapt these factors to the presentday world. The series is slated to screen globally in 2018.
For more information: www.targeting-mitochondria.com
Strategic presentation on High-content mitochondrial analysis by live-cell microscopy
Dr. Werner J.H. Koopman from the Deptartement of Biochemistry, Live-cell Bioenergetics group, Radboudumc, Nijmegen, The Netherlands. will give a talk during the Targeting Mitochondria World congress 2017 which will be held at Steigenberger Hotel, Berlin on October 23-24, 2017 and present his research about "High-content mitochondrial analysis by live-cell microscopy"
His research aims to unravel the interconnection between cell metabolism and mitochondrial morphofunction in single living cells during healthy and pathological conditions. Here high-content microscopy tools and their application in research and screening strategies will be presented."
For more information: www.targeting-mitochondria.com/
