Presentation of the most recent scientific data and perspectives related to mitochondrial DNA recombination, repair and segregation
Dr André Dietrich is Research Director at Institut de Biologie Moleculaire des Plantes, from CNRS, Universite de Strasbourg, France.
According Dr Dietrich: " Dynamics, maintenance and transmission of the mitochondrial DNA (mtDNA) are at the forefront of organellar genetics. Recombination plays a major role in these processes in many organisms and has mostly been documented at the genetic and molecular level in yeast and plant mitochondria. In these organisms, repeat-mediated recombination generates subgenomes and alternative mtDNA configurations. On the other hand, recombination takes part in mtDNA repair pathways, including errorprone mechanisms like break-induced replication. [...] The mechanisms underlying all these fundamental processes are little understood in mammals. Knowledge gained in plants and introduction of plant factors into mammalian model systems might shed new light into the field."
To know more about this strategic topic, you can register to Targeting Mitochondria World Congress on www.targeting-mitochondria.com
Optimizing Nature: Targeting Mitochondria with Enhanced Natural Antioxidants
Pr Paulo J. Oliveira fro
m the University of Coimbra, Portugal and the Vice-President, European Society for Clinical Investigation will be at the 7th World Congress on Targeting Mitochondria to present his research topic of "Optimizing Nature: Targeting Mitochondria with Enhanced Natural Antioxidants".
According to Pr Oliveira's research: "The role of mitochondria in aging and disease is well established. Although the role of oxidative stress is still controversial in what regards to the aging process, less doubt exists that mitochondria deterioration due to oxidative damage is an important component of several pathologies, including the so called lifestyle diseases. Although Nature provides a large number of antioxidants, commitment to healthy diets is lacking. Moreover, in a disease process, the supplementation of antioxidants is often necessary. Still, most antioxidants in supplements fail due to their poor targeting and bioavailability. We report here the development of enhanced natural antioxidants, which are accumulated by mitochondria, protecting these organelles from oxidative stress-mediated damage. We further show that the novel enhanced natural antioxidants preserve properties of the native compounds which are critical to improve cell resistance to stress, while showing a small degree of toxicity."
To know more about this strategic topic, you can register to Targeting Mitochondria World Congress on www.targeting-mitochondria.com
Tissue specificity of mitochondrial energy metabolism
60 years ago Britton Chance started to investigate the regulation of mitochondrial function. He defined the well known states of OXPHOS, describing the ADP phosphorylation in dependence on the cell work and the availability of oxygen and substrates. Later it was found that cytosolic calcium regulates both, the cell work and the mitochondrial activity. Rate of OXPHOS is determined by the rate of ADP transport into the mitochondria via creatine phosphate shuttle and direct diffusion as well as by a sufficient substrate supply to mitochondria. Mitochondrial properties depend on the cell type under investigation.
During Targeting Mitochondria 2016, Pr Franck Norbert Gellerich from Otto-von-Guericke University, Germany will present the tissue specificity of mitochondrial energy metabolism.
More information about the program, speakers and registration: www.targeting-mitochondria.com
Mitochondria Targeted Nanoparticle for Regenerative Therapy of Stroke
Dr. Shanta Dhar, from University of Georgia, USA was invited by the scientific committee of the 7th World Congress on Targeting Mitochondria to present his recent research "Mitochondria Targeted Nanoparticle for Regenerative Therapy of Stroke".
According to Dr. Dhar: Stroke is one of the most leading cause of impairment and death worldwide. Tissue plasminogen activator, the only Food and Drug Administration approved drug for ischemic stroke, suffers from several drawbacks when efficacy, safety, and the therapeutic window are considered. Neural stem cell-based tissue regeneration therapy can be an attractive addition for treatment of brain injuries. However, regenerative stem cell treatment suffers survival issues when implanted at the injury site dominated by a cytotoxic environment created by reactive oxygen species and inflammation. Neuro-protectants such as anti-inflammatory and/or anti-oxidative agents can be excellent addition to regenerative treatment.
Marvin Edeas stated: "During Targeting Mitochondria 2016, the new topic of mitochondria targeting nanoparticle will be largely discussed".
To know more about this strategic topic, you can register to Targeting Mitochondria World Congress on www.targeting-mitochondria.com
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
Glutathione depletion induces mitochondrial damage through CYLD and associated pathways of regulated necrosis
Volkmar Weissig and Marvin Edeas invited Carsten Culmsee to join the 7th World Congress on Targeting Mitochondria and to talk about new concept "Glutathione depletion induces mitochondrial damage through CYLD and associated pathways of regulated necrosis".
This new concept links mechanisms of oxidative stress to induction of regulated necrosis independent of death receptor signaling but through activation of the deubiquitinase CYLD. Further, this endogenous pathway of regulated necrosis leads to mitochondrial damage through activation of Drp-1 but not MLKL and is also highly relevant in neuronal death following acute brain injury as shown in models of cerebral ischemia and brain trauma.
Volkmar Weissig / Marvin Edeas / Chairmen of WMS
www.targeting-mitochondria.com
Mitochondrial targeting of RNA as a tool for therapy
Dr Ivan Tarassov, the Resear
ch Director in the CNRS, France, will join the 7th World Congress on Targeting Mitochondria and present his research topic on "Mitochondrial targeting of RNA as a tool for therapy"
Volkmar Weissig and Marvin Edeas invited Dr Tarassov to highlight the following strategic points:
1. Mechanisms and functional role of mitochondrial import of RNA
2. Allotopic strategy for mitochondrial therapy
3. Antigenomic strategy for mitochondrial therapy
If you are interested to know more about the speakers and the congress, don't hesitate to register to Targeting Mitochondria 2016: www.targeting-mitochondria.com
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
Subunit of mitochondria and hypertension control via miRNA: Presentation of the recent studies by Dao Wen Wang
The scientific committee of the World Mitochondria Society, chaired by Marvin Edeas and Volkmar Weissig, is honoured to welcome Dr Dao Wen Wang from Huazhong University of Science and Technology, China for the 7th World Congress on Targeting Mitochondria to be held in Berlin on October 24-26, 2016.
Dr Dao Wen Wang will talk about his research of "Subunit of mitochondria and hypertension control via miRNA" and will answer the following questions:
1. It has been widely accepted that miRNAs negatively regulate gene expression in the cytoplasm: why miRNAs positively regulate gene expression in the mitochondria?
2. You suggest that miR-21 lowers blood pressure by regulating mitochondrial gene expression and ROS production. However, a single miRNA has many different targets. It could be the miR-21 which resides in the cytoplasm doing the job instead.
3. MiR-21 has been extensively studied in cardiovascular diseases, silencing of miR-21 has been found to reduce cardiac fibrosis by previous studies, however, in your work, overexpression of miR-21reduces cardiac fibrosis, why?
If you are interested to know more about this study, you can register to the congress on www.targeting-mitochondria.com
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
What is the role of miR-181 family in the heart?
Dr Samarjit Das is a researcher at the Department of Pathology, Johns Hopkins University, Baltimore, USA.
According Marvin Edeas and Volkmar Weissig, Dr Das was invited to Targeting Mitochondria 2016 to talk about the precise experimental basis of the novel concept that mitochondrial microRNA (MitomiR) can regulate mitochondrial reactive oxygen species (ROS) production in the heart, and thereby influence myocardial disease development and progression.
Importantly, Dr Das will try to demonstrate the mechanist inside by which one microRNA can derived from the nuclear genome, matured in the cytoplasm, and then translocates to the mitochondria, and more importantly, regulates mitochondrial gene expression to affect mitochondrial function.
Finally, Dr Das will also show one example, where some of the family members of one microRNA can translocate into the mitochondria, and functionally active inside the mitochondria. However, other family members primarily targets nuclear gene in the cytoplasmic fraction.
If you would like to access to the program and registration: www.targeting-mitochondria.com
Marvin Edeas / Volkmar Weissig / Chairmen of WMS
