Glutathione depletion induces mitochondrial damage through CYLD and associated pathways of regulated necrosis

Volkmar Weissig and Marvin Edeas invited Carsten Culmsee to join the 7th World Congress on Targeting Mitochondria and to talk about new concept "Glutathione depletion induces mitochondrial damage through CYLD and associated pathways of regulated necrosis".

This new concept links mechanisms of oxidative stress to induction of regulated necrosis independent of death receptor signaling but through activation of the deubiquitinase CYLD. Further, this endogenous pathway of regulated necrosis leads to mitochondrial damage through activation of Drp-1 but not MLKL and is also highly relevant in neuronal death following acute brain injury as shown in models of cerebral ischemia and brain trauma.

Volkmar Weissig / Marvin Edeas / Chairmen of WMS
www.targeting-mitochondria.com