Patient-Specific Brain Organoids for Modeling Mitochondrial Diseases
Prof. Alessandro Prigione from, Heinrich Heine University (HHU), Germany will talk about "Patient-Specific Brain Organoids for Modeling Mitochondrial Diseases" during the congress which will be held on October 27-29, 2021 in Berlin & Online.
Mitochondrial diseases suffer from a lack of effective animal and cellular models. This hampers our understanding of the mechanisms underlying the neuronal pathology characteristics of mitochondrial diseases. Prof. Prigione used patient-derived induced pluripotent stem cells (iPSCs) and genome engineering with CRISPR/Cas9 to develop a human model of Leigh syndrome, which is the most severe mitochondrial disease in children and is currently incurable. Using neuronal cell cultures and three-dimensional brain organoids, he discovered previously unknown mechanisms causing the disease-specific neuronal defects, and identified two potential counteracting strategies for this rare mitochondrial disease with highly unmet medical need.
For more information about the article: https://www.nature.com/articles/s41467-021-22117-z
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Mitochondrial DNA in Cancer: The Overlooked Oncogenome
Dr. Payam A. Gammage from CRUK Beatson Institute, United Kingdom will join the Targeting Mitochondria 2021 Congress and will present a talk entitled "Mitochondrial DNA in Cancer: The Overlooked Oncogenome" during the congress.
Dr. Gammage will discuss the mutations of mtDNA that have been detected in human cancers for some decades, although their impact on the disease has not been clear and any potential role of mitochondrial genetics in cancer has been broadly overlooked. To better understand the role of mtDNA in cancer we repurposed targeted clinical sequencing data to assemble the largest dataset of partially matched tumour-normal mtDNA sequences to date (>40,000 tumours). Using this resource he has, Dr. Gammage defined the pan cancer landscape of mtDNA mutations, demonstrating clear evidence of respiratory complex-specific mutational recurrence and selection alongside the impact of mtDNA mutations on patient survival.
Key Publications
Gorelick AN, Kim M, Chatila WK, La K, Hakimi AA, Berger MF, Taylor BS, Gammage PA, Reznik E. Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA. Nat Metab. 2021 Apr 8. doi: 10.1038/s42255-021-00378-8
Jackson CB, Turnbull DM, Minczuk M, Gammage PA. Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective. Trends in Molecular Medicine. 2020; 26: 698-709
Gammage PA, Frezza C. Mitochondrial DNA: the overlooked oncogenome? BMC Biology. 2019;17:53.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Exercise-Induced, Mitochondrial-Mediated Cell Death in Arrhythmogenic Cardiomyopathy
Dr. Stephen Chelko from Department of Biomedical Sciences, Florida State University, USA will join the Targeting Mitochondria 2021 Congress which will be held on October 27-29, 2021 and will give a presentation on his recent work in Science Translational Medicine on the "Exercise-Induced, Mitochondrial-Mediated Cell Death in Arrhythmogenic Cardiomyopathy".
Arrhythmogenic Cardiomyopathy (ACM) is a familial heart disease with a high incidence of sudden cardiac death in the young and in athletes. Reduced penetrance and variable expressivity complicate early diagnosis and management of ACM. More and more evidence on the deleterious impact of exercise in ACM is growing, yet these studies all implicate the arrhythmic risk and/or hemodynamic load on the heart in response to exercise. New evidence demonstrates that endurance exercise leads to mitochondrial dysfunction, ROS generation, and large-scale myocyte death in ACM.
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Glucose Metabolism Control of T Cell Immunity
Prof. Ming Li, from Immunology Program, Memorial Sloan Kettering Cancer Center, USA will give a presentation entitled "Glucose Metabolism Control of T Cell Immunity".
Prof. Ming Li is a Member of the Immunology Program at Memorial Sloan Kettering Cancer Center and Professor at Weill Cornell Graduate School of Medical Sciences. His laboratory studies immune regulation and its relevance to diseases including cancer. Recent work has focused on the signaling, metabolic, and transcriptional mechanisms of T cell regulation as well as tumor-elicited innate and adaptive immune responses, and how this knowledge can be translated for novel cancer immunotherapies. Dr. Li has received a number of honors including a Howard Hughes Medical Institute (HHMI) Faculty Scholar Award, a Rita Allen Foundation Scholar Award, an American Cancer Society Scholar award and the 2016 American Association of Immunologists (AAI)-BD Bioscience Investigator Award for outstanding contributions to the field of immunology.
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
The Bioenergetics Consequences of Winter Cold in Small Birds
Dr. Andreas Nord, researcher in evolutionary ecology at Lund University, Sweden, will present his study on "The Bioenergetics Consequences of Winter Cold in Small Birds".
Dr. Nord highlighted: "Small birds at high latitude face converging energetic challenges in winter, when low air temperature increases the energy cost of staying warm at the same time as short day length and snow constrain refuelling opportunities. The thermoregulatory adaptations that permit existence in such environments are well studied on organismal levels, but analogous processes in the cellular machinery fuelling thermoregulation are poorly understood. In this talk, I will outline how seasonal and diurnal changes in mitochondrial function interact with whole-animal physiology to help birds stay warm when it is cold".
Please follow this link to read detailed news on his research.
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Circulating Mitochondrial DNA as an Early Indicator of Severe Lung Disease
Prof. Andrew E. Gelman from Washington University School of Medicine, USA will give a presentation entitled "Circulating Mitochondrial DNA as an Early Indicator of Severe Lung Disease".
Prof. Gelman will discuss how cell-free mitochondria DNA levels have been used to evaluate the severity of solid organ injury. He will also cover the implications of cell-free mitochondrial DNA findings in several pulmonary diseases including COVID-19. Additionally, Prof. Gelman will talk about the possible tissue origins of cell-free mitochondria DNA and whether it is the result of an overexuberant immune response or a sign of mitochondrial dysfunction.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Deciphering strategic interactions between mitochondrial and nuclear genome
Dr. José Antonio Enríquez from Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain. Dr. Enríquez will give a presentation entitled "Deciphering strategic interactions between mitochondrial and nuclear genome".
Dr. Enríquez has done probably the most advanced studies on nuclear-mitochondrial interactions and their effect on organisme longevity and health. He focuses on distinct combinations of nuclear and mitochondrial genomes and their effect at the organismal level (lifespan, health condition, predisposition to disease), as well as investigates the underlying mechanism including respiratory complexes and supercomplexes.
Last year he published a seminal paper in Science Advances showing the dynamics of non-pathogenic heteroplasmy (segregation of one of the two mtDNA genomes in different tissues) and their dependence on OXPHOS performance (PMID: 32832682). See also a recent review (PMID: 33369015) on the interactions between mitochondrial and nuclear genome.
Heteroplasmic mouse models harboring in the same cytoplasm, different non‐pathological mtDNA variants‐haplotypes. MtDNA preference is cell‐type‐specific and not tissue‐specific. Also, the metabolic differentiation program determines the preferred mtDNA haplotype and the mtDNA segregation is driven by functional selection and strongly modulated by the crosstalk between the nucleus and mitochondria. © 2020 The Authors. IUBMB Life
https://doi.org/10.1002/iub.2434
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
A session dedicated to Nuclear-mitochondrial interactions and their effect on longevity and health will be organized
A session dedicated to the "Nuclear-mitochondrial interactions and their effect on longevity and health" will be organized by Prof. Miria Ricchetti, Team Stability of Nuclear and Mitochondrial DNA, Institut Pasteur, France that will chair the session.
Among the speakers:
 Introduction & Presentation of SessionDr. Miria Ricchetti, Team Stability of Nuclear and Mitochondrial DNA, Institut Pasteur, France |
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Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
