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Exploring Mitochondrial Oscillation and Resonance: Impact on ATP Production and Distribution in Health and Diseases
What do we mean by Mitochondrial oscillations and resonance?
Mitochondrial oscillations and resonance could indeed have significant implications for ATP production and distribution. As the primary "powerhouses" of the cell, mitochondria are responsible for the bulk of ATP production through the process of oxidative phosphorylation. The efficiency of this process is intimately linked to the mitochondrial membrane potential, which undergoes periodic oscillations.
These oscillations can influence the rate of ATP production in a couple of ways. When the membrane potential is high, the mitochondria are in an energy-conserving state, and ATP production is typically efficient. Conversely, when the membrane potential is low, the mitochondria are in an energy-dissipating state, and ATP production may be less efficient.
In terms of ATP distribution, mitochondria are known to form dynamic networks within cells, allowing for the efficient transfer of ATP and other metabolites to where they are most needed. The oscillatory behavior of mitochondria could potentially play a role in regulating this distribution process. For instance, changes in the oscillatory state of a particular mitochondrion could trigger the redistribution of ATP within the mitochondrial network, allowing the cell to rapidly respond to changing energy demands.
Moreover, the concept of mitochondrial resonance could further impact ATP distribution. If different mitochondria within a cell or tissue can 'resonate' with each other – that is, synchronize their oscillations – this might enable a more coordinated and efficient distribution of ATP throughout the cell or tissue.
The concept of mitochondrial resonance is a fascinating one and may have far-reaching implications for how energy is distributed within cells and tissues.
As an analogy, consider the way synchronized swimmers can move more efficiently through water by coordinating their movements. Similarly, if different mitochondria within a cell or tissue can 'resonate' with each other – that is, synchronize their oscillations – this might enable a more coordinated and efficient distribution of ATP throughout the cell or tissue.
When mitochondria are in resonance, the oscillations of their membrane potentials are synchronized. This synchronization might facilitate the formation of a more efficient energy distribution network, allowing ATP and other metabolites to be rapidly and efficiently transported to where they are most needed within the cell or tissue.
This could be especially important in cells with high energy demands, such as neurons or muscle cells, or in situations where energy needs can change rapidly, such as during exercise or in response to stress. Resonance might allow these cells to quickly ramp up ATP production and distribution in response to increased energy demand, ensuring that all parts of the cell have access to the energy they need to function optimally.
Mitochondrial Oscillation - Project's Aim
Our goal is to probe deeper into the complex biological phenomena of mitochondrial dynamics - oscillations (continuous changes in mitochondrial membrane potential) and resonance (amplification of effects of an external force matching a system's own natural frequency) - and their influence on the cellular energy landscape.
These oscillations play a pivotal role in cellular signaling, energy metabolism, and reactive oxygen species production, with alterations linked to various pathological conditions such as neurodegenerative diseases and cancer. Moreover, mitochondrial resonance potentially enhances inter-mitochondrial and cellular communication, optimizing energy transfer and signaling pathways.
A key aspect of this project focuses on the implications of these processes for ATP production and distribution. Mitochondria, as cellular powerhouses, are primarily responsible for ATP production via oxidative phosphorylation.
This project will explore:
- How changes in mitochondrial membrane potential during oscillations influence the efficiency of ATP production.
- How mitochondrial network dynamics, regulated by oscillatory behavior, can impact ATP distribution within the cell.
- How mitochondrial resonance may enable a more coordinated and efficient distribution of ATP throughout cells or tissues. The concept of mitochondrial resonance could further impact ATP distribution. If different mitochondria within a cell or tissue can 'resonate' with each other – that is, synchronize their oscillations – this might enable a more coordinated and efficient distribution of ATP throughout the cell or tissue.
By advancing our understanding of these processes, we aim to develop novel therapeutic strategies for diseases characterized by disrupted mitochondrial function.
How to submit?
Pharmaceutical & Non-Pharmaceutical Mitochondria-Based Innovations will be discussed during Targeting Mitochondria 2023
During the session on the future of pharmaceutical and non-pharmaceutical mitochondria-based innovations, several exciting topics will be discussed. Here is a breakdown of the key areas that will be explored:
Clinical Trials and Advancements in Pharmaceutical Interventions:
This part of the session will focus on the latest developments in pharmaceutical interventions targeting mitochondria. Discussions will cover ongoing clinical trials, novel drug candidates, and emerging therapeutic strategies aimed at modulating mitochondrial function to treat various diseases and conditions.
Food Targeting Mitochondria:
The potential of using nutrition and specific dietary interventions to target and optimize mitochondrial function will be explored. This includes identifying food components, compounds, or diets that can positively influence mitochondrial health, energy production, and overall cellular metabolism.
Mitochondria's Role in Ophthalmology:
This topic will delve into the significance of mitochondria in ocular health and diseases. Discussions will revolve around mitochondrial dysfunction in eye disorders such as age-related macular degeneration, glaucoma, and inherited retinal diseases. Innovative approaches and potential therapies that target mitochondrial dysfunction in these conditions will be explored.
Exosomes-Based Mitochondrial Medicine:
The session will discuss the emerging field of using exosomes as delivery vehicles for mitochondrial therapeutics. Exosomes, small vesicles secreted by cells, hold promise for targeted delivery of mitochondria-related cargo, including genetic material, proteins, and small molecules. The potential of exosomes in treating mitochondrial disorders and other diseases will be examined.
Effects of Electromagnetic Waves on Mitochondria:
This part of the session will address the impact of electromagnetic waves on mitochondrial function and cellular health. Discussions will explore the potential effects of electromagnetic radiation, such as those emitted by electronic devices and wireless communication, on mitochondrial bioenergetics, oxidative stress, and potential implications for human health.
The future of pharmaceutical and non-pharmaceutical mitochondria-based innovations holds great potential for developing novel therapeutic approaches and strategies to modulate mitochondrial function and improve health outcomes. This session aims to shed light on these exciting developments, fostering discussions and collaborations among researchers, clinicians, and industry experts in advancing mitochondria-focused therapies and interventions.
Read more about all of Targeting Mitochondria 2023 Sessions.
World Mitochondria Society
Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany
"Comment Evaluer l'Activité Mitochondriale ?" - Formation 2024
Au programme de la Société Mondiale sur la Mitochondrie (WMS) cette année,une nouvelle formation dédiée à l’évaluation de l’activité mitochondriale, le mercredi 14 mai 2023.
Une formation en Anglais sera aussi disponible un jour avant le congrès mondial sur la mitochondrie : Octobre 2024. La date exacte sera précisée ultérieurement.
Pour plus d'informations :
Inscription à la formation
| Catégories et Modalités | Tarifs | Inscription en ligne |
| Participation en ligne | 500 € HT | Paiement |
| Académiques – En personne | 785 € HT | Paiement |
| Industriels – En personne | 885 € HT | Paiement |
* Le paiement en ligne se fait par carte de crédit.
** Pour les virements bancaires, veuillez-nous contacter.
WMS 2023 Workshop: Evaluation of Mitochondria Function, Dysfunction, and Activities
WMS 2023 Workshop: Aims & Objectives
The workshop on the Evaluation of Mitochondria Function, Dysfunction, and Activities organized by the World Mitochondria Society sounds like a valuable event for individuals interested in enhancing their understanding of mitochondria, metabolism, and bioenergetics. Set to take place on October 11, 2023, the workshop is conveniently scheduled one day prior to the Targeting Mitochondria 2023 Congress.
The workshop has several objectives, including /the presentation of technological tools used for studying and analyzing mitochondria, mitochondrial markers relevant to medical studies, methods for analyzing mitochondria and their functions (such as bioenergetics, biogenesis, dynamics, and mitophagy), and different biochemical diagnostic strategies for mitochondrial diseases.
Practical cases will also be discussed, allowing participants to delve into real-world applications and scenarios.
Who Should Attend the Workshop?
This workshop is designed to benefit anyone seeking to enhance their skills and knowledge in the field of mitochondria, metabolism, bioenergetics, and the latest therapeutic innovations.
Attendees can expect to receive a comprehensive report book that covers each session, providing summaries and materials presented during the workshop. Additionally, the report will include supplementary protocols and references, further enriching the learning experience.
For those unable to attend the workshop, the option to order the report book in PDF format allows for access to the all information presented at the event. This way, individuals can still benefit from the knowledge shared by experts in the field and stay up-to-date with the latest advancements in mitochondria research.
Overall, the workshop offers a unique opportunity to expand one's understanding of mitochondria and related topics, connect with fellow professionals in the field, and gain insights into cutting-edge research and diagnostic strategies.
WMS 2023 Workshop: Topics & Sessions
The workshop schedule provided outlines the sessions and topics that will be covered during the event dedicated to the evaluation of mitochondria function. Here's a breakdown of each session:
Session 1: How to evaluate and analyze mitochondria function in 2023
This session will cover various approaches to studying mitochondria function, including in vitro, in vivo, and ex vivo studies. The session will explore the technological tools used for studying and analyzing mitochondria, such as advanced imaging techniques, molecular biology methods, and functional assays. Additionally, mitochondrial markers relevant to medical studies will be discussed, focusing on markers that provide insights into mitochondrial function and dysfunction in different contexts.
Specific topics covered in Session 1:
• Technological tools for studying and analyzing mitochondria
• Mitochondrial markers in medical studies
• Significance and functionality of the citrate synthase enzyme
• Analysis of mitochondrial respiratory chains
• Study of mitophagy (the process of selective degradation of mitochondria)
Session 2: Methods for analyzing mitochondrial function: Bioenergetics
This session will focus on bioenergetics, which refers to the study of energy conversion and utilization in cells. It will cover methods and techniques used to evaluate mitochondrial bioenergetics, including assessing oxygen consumption rate (OCR) and measuring ATP production. These techniques provide insights into mitochondrial respiration and energy generation.
Session 3: Methods for analyzing mitochondria: Biogenesis, dynamics, and mitophagy
This session will delve into the processes of mitochondrial biogenesis (formation of new mitochondria), dynamics (movement, fusion, and fission of mitochondria), and mitophagy (selective degradation of mitochondria). The methods and approaches used to study these processes will be discussed, highlighting techniques such as live-cell imaging, molecular biology tools, and functional assays.
Session 4: Biochemical strategies for the diagnosis of mitochondrial disorders
This session will focus on the biochemical strategies employed in the diagnosis of mitochondrial disorders. Various laboratory tests and assays used to assess mitochondrial function and identify abnormalities will be discussed. These strategies are crucial for diagnosing and characterizing mitochondrial diseases.
Presentation of Practical Cases: During this segment, practical cases related to mitochondrial function evaluation and disorders will be presented. These cases will provide real-world examples and insights into applying the knowledge and techniques discussed throughout the workshop.
Presentation of the Workshop Report & Interactive Discussion:
The workshop report will be presented, summarizing the key points, materials, and protocols covered in each session. This will be followed by an interactive discussion, allowing participants to ask questions and engage with the presenters and fellow attendees.
Conclusion and End of the Day: The workshop will conclude with a summary of the key takeaways from the day's sessions, providing a cohesive wrap-up of the topics covered. The day's events will come to an end following the conclusion.
It's important to note that the detailed protocols and specific measurement techniques mentioned in the workshop schedule will likely be elaborated on during the respective sessions, providing participants with a comprehensive understanding of how to conduct these analyses and measurements effectively.
Dr. Naig Gueguen, PhD
Mitovasc Institute, Mitolab team,
INSERM 1083, CNRS 6215,
Centre Hospitalier Universitaire d’Angers, Angers, France
Sessions & Topics Targeting Mitochondria 2023
Blooming Topics Targeting Mitochondria will be elaborated this annual meeting:
- Mitochondrial Biodynamics: Standpoint 2023
- Mitochondria & Longevity: Towards Expanding Life Span
- Novel Advances in Mitochondria Quality Assessment
- Mitochondria & Our Changing Environment
- Pharmaceutical & Non-Pharmaceutical Mitochondria-Based Innovations
- Mitochondria, Microgravity & Space Travel – A glance into the future
