Personalized Medicine in Mitochondrial Health and Disease: Myth and Reality

Ciro Leonardo Pierri3Prof. Ciro Leonardo Pierri from the University of Bari, Italy, will join the 14th edition of the World Conference on Targeting Mitochondria 2023, held in Berlin, Germany, from October 11th to 13th. In this conference, Prof. Pierri will give a talk entitled "Personalized Medicine in Mitochondrial Health and Disease: Myth and Reality.

Mitochondrial diseases may result from mutations affecting nuclear or mitochondrial genes, encoding mitochondrial proteins, or non-protein coding mitochondrial RNA. Despite the great variability of affected genes, in the most severe cases, a neuromuscular degenerative phenotype is observed, and no specific therapy exists for a complete recovery from the disease.

The most used treatments are symptomatic based on the administration of antioxidant cocktails in combination with antiepileptic/antipsychotic drugs. Unfortunately, antioxidant therapies have met limited success and it is still urgent to highlight new/real pharmacological targets and to design/identify highly selective/efficient drugs to rescue mitochondrial-impaired pathways. In this context, very little attention was dedicated to proteins responsible for the crosstalk between mitochondria and cytoplasm such as mitochondrial transporters (i.e., SLC25A family members) and FAD/NADH dehydrogenases (i.e., AIF), playing a crucial role in the maintenance of metabolites and oxidative balance, as well as in the regulation of mitochondrial apoptosis.

Prof. Pierri will discuss molecular aspects of the limited success of antioxidant therapies, and will illustrate the role of mitochondrial transporters and FAD/NADH dehydrogenases in mitochondrial function for the possible development of new MD treatments.

Join Targeting Mitochondria 2023 to learn more about Prof. Perrie's talk. 

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany


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