Mitochondria Transplantation Between Living Cells

Dr Julia A. VorholDr. Julia A. Vorholt, from ETH Zurich, Switzerland, will join us this year to present her most recent findings on "Mitochondrial Transplantation Between Living Cells" in a session entitled "Mitochondria Transplantation and Transfer

Mitochondria and the complex endomembrane system are hallmarks of eukaryotic cells. To date, it has been difficult to manipulate organelle structures within single live cells.

Dr. Vorholt developed a FluidFM-based approach to extract, inject and transplant organelles directly from and into living cells with subcellular spatial resolution. The technology combines atomic force microscopy, optical microscopy and nanofluidics to achieve force and volume control with real-time inspection.

The approach enables the transfer of controlled quantities of mitochondria into cells while maintaining their viability and monitoring their fate in new host cells. Transplantation of healthy and drug-impaired mitochondria into primary keratinocytes allows real-time tracking of mitochondrial subpopulation rescue. After transfer of mitochondria into somatic cells and cell propagation over generations, she shows that donor mtDNA was replicated in recipient cells without the need for selection pressure.

The approach opens new prospects for the study of organelle physiology and homeostasis, but also for mechanobiology, synthetic biology, and therapy.

Remember that Targeting Mitochondria 2022 also gives you the chance to present your new research related to this session by submitting your abstract.

Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany

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