Mitochondria Targeted Near-Infrared Aggregation-Induced Emission for Photodynamic Ablation of Liver Cancer Cells

 Mitochondria Targeted Near-Infrared  Aggregation-Induced Emission for Photodynamic Ablation of Liver Cancer Cells 1

Multifunctional nano-photosensitizer was used for mitochondrial-targeting photodynamic ablation of liver cancer cells.

News Release, World Mitochondria Society, Berlin - Germany – September 6, 2022

The aggregation-induced emission photosensitizers (AIE-PSs) manifest a multitude of notable superiorities in terms of high specificity to organelles, high-efficient singlet oxygen (1O2) generation as well as enhanced fluorescence intensity, which provides a feasible approach to overcome the problems such as the insufficient generation of reactive oxygen species (ROS) caused by grave aggregation-induced quenching (ACQ) and the lack of specific targeting existing in traditional PSs, but extremely challenging.

Herein, a series of near-infrared (NIR) AIE luminogens (AIEgens) for targeting mitochondrial was devised and synthesized by regulating the D-A intensity assembly molecular engineering, which fabricating a progressively stronger intermolecular charge transfer (ICT) state to accelerate highly effective intersystem crossing (ISC) of excited electrons by the synergistic effect of thiophene and quinolinium.

  • The optimal NIR AIE-PS (DTTVQ-OH) revealed excellent photostability, biocompatibility, precise mitochondria targeting, extremely high generation yield of 1O2 and superior phototoxicity in living HepG2 cells.
  • Apoptosis assay and cell migration experiment further demonstrated that DTTVQ-OH could efficaciously restrain cell proliferation and induce/speed up cancer cell death.
  • DTTVQ-OH could selectively distinguish cancer cells and normal cells by difference of fluorescence intensity in high resolution without the assist of any extra targeting ligands.

As a consequence, this work provides a rational and practicable strategy for the specific targeted molecular engineering of AIE-PSs, which gives impetus to the development of fluorescence imaging-guided photodynamic therapy fields.

Full Article.

© Image -Xue et al., Sensors and Actuators B: Chemical 2022

Targeting Mitochondria 2022 will dedicate a whole session to "Translational Therapies - Focus on Infrared Therapies". Submit a related abstract.

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