Delivery of Mitochondria via Extracellular Vesicles: A New Horizon in Drug Delivery
News Release, World Mitochondria Society, Berlin - Germany – March 23, 2022
Extracellular vesicles (EVs) have been well reported to mediate intercellular communication and carry a rich cocktail of innate cargo including lipids, proteins and nucleic acids.
Keeping in mind, the field of drug delivery has made tremendous advances in increasing the therapeutic potential of a variety of drug candidates spanning from small molecules to large molecular biologics such as nucleic acids, proteins, etc. EVs are a promising class of natural, cell-derived carriers for drug delivery.
EVs of particle diameters <200 nm are referred to as small EVs (sEVs) and medium-to-larger particles of diameters >200 nm are referred to as m/lEVs. The m/lEVs naturally incorporate mitochondria during their biogenesis.
It has been established that mitochondrial damage and dysfunction play a causal role in multiple pathologies such as neurodegenerative diseases, cardiovascular and metabolic diseases—suggesting that m/lEV-mediated mitochondria delivery can be of broad biomedical significance.
In this brilliant review, Dr. Devika S.Manickam discusses the potential of m/lEVs as carriers for the delivery of healthy and functional mitochondria.
She states that a major advantage of harnessing m/lEVs is that the delivered mitochondria are capable of using endogenous mechanisms for repairing the cellular damage. She also highlights the delivery potential of m/lEVs based on the studies that have been conducted so far, and discusses unaddressed issues towards their development as a novel class of mitochondria carriers.
Dr. Manickam will be joining us in Targeting Mitochondria 2022 to give her talk within the "Extracellular Vesicles & Mitochondria: The Target" session. Register now for a chance to benefit from the exprience of professional speakers in this field.
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Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany
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