Hydrogen sulfide and mitochondrial function: Presentation of the scientific advances

MarkusDuring the 8th World Congress on Targeting Mitochondria 2017, Dr. Csaba Szabo from University of Texas, USA will present his work on "Hydrogen sulfide and mitochondrial function".

According to him: "H2S has emerged over the last decade as an important, endogenously produced biological mediator. Inhibition of cytochrome C oxidase is the longest known mitochondrial effect of H2S. However, work of recent years showed that H2S, at lower concentrations, acts as an electron donor to the mitochondria, and serves as an inorganic substrate for mitochondrial electron transport. Additional mitochondrial effects of H2S include the stimulation of mitochondrial electron transport via inhibition of mitochondrial phosphodiesterase 2A, and activation of Complex V via sulfhydration. In some disease conditions (e.g. ischemia, vascular disease, diabetic complications), H2S levels are decreasing and H2S donation can exert therapeutic effects. In other conditions, the idea that H2S can be used to induce an on-demand metabolic suppression ("hibernation") has been proposed. In yet other conditions (e.g. inflammation, septic shock, burn injury and certain forms of cancer), H2S overproduction occurs and H2S biosynthesis inhibitors may be a therapeutic approach of the future. The talk will overview the various mitochondrial actions of H2S and will highlight some of the physiological, pathophysiological and therapeutic implications of these processes."

More information: www.targeting-mitochondria.com

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