Mitochondrial Presequence Protein Translocation

Nils Wiedemann 1Prof. Nils Wiedemann, Universität Freiburg, Germany, will join Targeting Mitochondria 2023 to present a talk entitled: "Mitochondrial Presequence Protein Translocation".

Virtually all of the ~1,000 different mitochondrial proteins are synthesised in the cytosol and must be imported into the organelle. Most of these mitochondrial precursor proteins contain an amino-terminal presequence, which forms a positively charged amphiphilic alpha-helix. The TIM23 translocase sorts these presequence proteins into the inner membrane or matrix. Prof. Wiedemann and colleagues mapped the interaction of the essential subunit Tim17 with presequence containing precursor proteins.Tim17 contains conserved negative charged residues close to the intermembrane space side of the inner membrane, which are essential for presequence protein translocation along a distinct transmembrane cavity of the Tim17-bilayer interface.


About Prof. Wiedemann,

Professor (apl.) of Biochemistry and Molecular Biology, University of Freiburg, Germany
Prof. Wiedmann won the Young Investigator Award, German Society for Biochemistry and Molecular Biology (GBM) Frankfurt in the year 2007.


Join Targeting Mitochondria 2023 to learn more about Prof.  Wiedemann's interesting findings. Read more about Prof. Wiedmann's latest research.

Targeting Mitochondria 2023 Congress
October 11-13, 2023 - Berlin, Germany

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