Targeting Mitochondria 2022 Best Short Oral Presentation Award

Mercedes Fernandez-Moreno short oral presentation winner wms 2022Mercedes Fernandez-Moreno, Instituto de Investigación Biomédica de A Coruña (INIBIC), Spain, was discerned the best short oral presentation award for her innovative talk on the Approach for Using Intra-Articular Injection of Mitochondria to Treat Osteoarthritis.

"Nowadays there is not cure or an efficient treatment for osteoarthritis (OA), despite of its the most common rheumatology illness and a major cause of pain and disability in older adults. The relation between mitochondria alteration and OA was described in several studies in which the authors explained how mitochondrial alteration can modulate the chondrocyte function and its survival during this pathogenesis

Mitochondria have proposed as a potential therapeutic target for OA. We hypothesized that transplantation of heterologous mitochondria from healthy donor would ameliorate the OA effects. The analysis of in vivo model showed that mitochondria injection was safety and no inflammatory response was observed in the joint. These preliminary data give us the possibility to continue studying the mitochondrial transplantation as an efficient treatment for OA.

Taken into account our preliminary data, we will continue in the develop of more robust data generating a complete in vivo model to confirm the role of healthy mitochondria over the OA cartilage."