Mitochondria Rich Extracellular Vesicles & Ageing: What is the Link?


Electron microscopy showed EVs of typical size and morphology

News Release, Wolrd Mitochondria Society, Berlin - Germany – March 10, 2022

The accumulation of oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a major role in aging, "the mitochondrial free radical theory of aging". Circulating cell-free mtDNA (ccf-mtDNA) in blood can be considered as disease biomarkers.

Extracellular vesicles (EVs), the small lipid-bound vesicles capable of shuttling cargo, take part in intercellular communication systems.

In thier fascinating research, Lazo et al.:

  • Reported that a portion of ccf-mtDNA in plasma is encapsulated in EVs.
  • Studied whether EV mtDNA levels vary upon aging by analyzing mtDNA in EVs from individuals aged 30–64 years cross-sectionally and longitudinally.

They reported the following:

  1. EV mtDNA levels decreased with age.
  2. The maximal mitochondrial respiration of cultured cells was differentially affected by EVs from old and young donors.

In conclusion, their results suggested that plasma mtDNA is present in EVs, that the level of EV-derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age-dependent manner.

In Targeting Mitochondria 2022, a whole session will be dedicated to Extracellular Vesicles & Mitochondria: The Target, in which Dr. Marc Germain and Dr. Devika S. Manickam will share with us their 

Original article

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Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany

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