Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
Therapeutic strategies of mitochondrial transfer for cardiovascular diseases.
This informative review by Chen et al. studied the phenomenon of mitochondrial transfer in cardiovascular diseases.
Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. This cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury.
In this review, they summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. They also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders.
This topic and many more are to be presented in our 13th Annual Meeting 2022 - in Germany
Authors: Jun Chen, Jinjie Zhong, Lin-lin Wang, and Ying-ying Chen
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