Severe SARS-CoV-2 Infection as a Marker of Undiagnosed Cancer


News Release, World Mitochondria Society, Berlin - Germany – June 7, 2023

This population-based study by Dugerdil et al, published in scientific reports, investigated if a severe SARS-CoV-2 infection represents a marker of an undiagnosed cancer.

The SNDS database was used, identified from 02/15/2020 to 08/31/2021, 41,302 individuals hospitalized in intensive care unit due to SARS-CoV-2 (ICU-gr) and 713,670 control individuals not hospitalized for SARS-CoV-2 (C-gr). Individuals were matched according to year of birth, sex and French department.The cancer incidence was compared in the two groups during the follow-up period, using Cox proportional hazards models adjusted on matching variables, socioeconomic characteristics and comorbidities.

In the ICU-gr, 2.2% was diagnosed with a cancer in the following months, compared to 1.5% in the C-gr. The ICU-gr had a 1.31 higher risk of being diagnosed with a cancer following hospital discharge compared to the C-gr. A global similar trend was found when competing risk of death was taken into account. A significant higher risk was found concerning renal, hematological, colon, and lung cancers.

The obtained results suggest that a severe SARS-CoV-2 infection may represent a marker of an undiagnosed cancer.

Article DOI.

Image credits: by kjpargeter on Freepik

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