Mitochondria Derived “Mitovesicles” in Down Syndrome
News Release, World Mitochondria Society, Berlin - Germany – March 29, 2022
Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer’s disease (AD).
Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, D'acunzo et al, were able to identify and characterize a previously unknown population of double-membraned EVs containing multiple mitochondrial proteins distinct from previously described EV subtypes, including microvesicles and exosomes.
Representative photomicrographs of brain EVs imaged by either cryoEM or TEM (insets with red borders)
They termed these newly identified mitochondria-derived EVs “mitovesicles”.
They demonstrated that brain-derived mitovesicles contain a specific subset of mitochondrial constituents and that their levels and cargo are altered during pathophysiological processes where mitochondrial dysfunction occurs, including in DS.
Thus, the brain cells constitutively secrete mitochondrial vesicles and this pathway is altered under conditions in which mitochondrial dysfunction occurs, providing new insights into heterogeneous EV biology and its relationship with mitochondrial dynamics.
This brilliant discovery opens the door to future development of a method for the selective isolation of mitovesicles paves the way for the characterization in vivo of biological processes connecting EV biology and mitochondria dynamics and for innovative therapeutic and diagnostic strategies.
Targeting Mitochondria 2022 will specialize a whole session entitled “Extracellular Vesicles & Mitochondria: The Target”. Professional speakers like Dr. Ines Khadimallah and Dr. Marc Germain will be sharing with you their experties in this field on October. Join us and remember you still have timw to benefit from the early bird offer.
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Targeting Mitochondria 2022 Congress
October 26-28, 2022 - Berlin, Germany
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