Targeting Mitochondria 2020 - Final Agenda

 Wednesday, October 28, 2020

Mitochondria Workshop 2020
How to Evaluate Mitochondria Function?

- Online Workshop -


Introduction of Targeting Mitochondria Workshop
Carole Nicco, Institut Cochin -INSERM U1016, Université de Paris, France

Workshop by Naïg Gueguen, PhD, Mitovasc Institute, Mitolab team,
INSERM 1083, CNRS 6215, Centre Hospitalier Universitaire d’Angers, Angers, France

Session 1:
Bioenergetics.  Metabolism, mitochondrial respiration rates, ATP synthesis,

mitochondrial membrane potential and respiratory chain activities.

Session 2
: Mitochondrial biogenesis, dynamics and mitophagy

Session 3
: Biochemical diagnosis of mitochondrial diseases


For full agenda, registration and information, please follow this link

Thursday, October 29, 2020
Targeting Mitochondria 2020 Agenda

- Day 1 -


Introduction of Targeting Mitochondria 2020
Carole Nicco, Institut Cochin -INSERM U1016, Université de Paris, France

Welcome Note of Targeting Mitochondria 2020
Volkmar Weissig, President of the World Mitochondria Society, Midwestern University, USA
Marvin Edeas, University Paris Descartes, Inserm 1016, Institute Cochin, France


Session 1 - Recent Advances on Mitochondrial Dysfunctions and
Dynamics in Chronic Diseases: The Mechanisms


Roles for mitochondrial dysfunction in Alzheimer’s disease
Benedict Albensi, Max Rady College of Medicine - University of Manitoba, Canada

FBXL4 Deficiency leads to increased clearance of Mitochondria
Nils-Göran Larsson, Karolinska Institutet, Sweden

Down Syndrome: Role of hydrogen sulfide overproduction in the pathogenesis of mitochondrial dysfunction
Csaba Szabo, Université de Fribourg, Switzerland

Mitochondrial dysfunction in autism is distinct from mitochondrial disease
Richard E. Frye, Phoenix Children's Hospital, USA

Mitochondrial disease community registry (MDCR): Perspectives from patients and families, lessons learned from the data
Sophia Zilber from Boston, USA


Session 2 - Extracellular Mitochondria:
The Intriguing Localization and Role


The Cell-free respiratory competent mitochondria in blood: Strategic role and application
Alain Thierry, Montpellier Cancer Research Institute, INSERM, France

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis
Marvin Edeas
University Paris Descartes, Inserm 1016, Institute Cochin, France


Session 3 - An update: The Challenge of Qualitative and Quantitative Assessment of  Mitochondrial Function in vitro and in vivo


The Challenge of Qualitative and Quantitative Assessment of Mitochondrial Function in Vitro And in Vivo: What We Know in 2020?
Egbert Mik, University Medical Center Rotterdam, The Netherlands

Mitochondria devices: New methods to detect mitochondria dysfunction
Naïg Gueguen,  MitoVasc Institute, Angers University Hospital Center, France

Control of cellular bioenergetics by cytosolic calcium
Franck Norbert Gellerich, Otto-von-Guericke University, Germany


Short Oral Presentations of Day 1:

Use of the type 2 CRISPR-CAS system for human mitochondrial genome editing
Natalia Nikitchina, Strasbourg University, France

Impact of Tafazzin knockout on mitochondrial and cellular properties
Gayatri Jagirdar, University medicine Greifswald, Germany

Retrograde signaling by an MT-DNA-Encoded non-coding RNA preserves mitochondrial bioenergetics
Anna Blumental-Perry, State University of New York, USA

Aralar sequesters GABA into hyperactive mitochondria causing social behavior deficits
Alexandros Kanellopoulos, University of Lausanne, Switzerland

Alcohol induces mitochondrial dysfunction in human induced pluripotent Stem cell-derived three-dimensional Cerebral Organoids
Xiaowen Bai, Medical College of Wisconsin, USA

Overexpression of MitoNEET in osteoblasts leads to impaired bone mass and energy metabolism
Anyonya Guntur, Maine Medical Center Research Institute, USA

Diet-dependent gut microbiota modulates adult neurogenesis through mitochondrial stress modulation
Susana Solá, Universidade de Lisboa, Portugal

Mitochondrial dysfunction in skeletal muscle of a mouse model (OIM) of severe human osteogenesis imperfecta
Victoria Gremminger, University of Missouri, USA

Aging-induced mitochondrial fission impairs germline stem cell maintenance via suppressing stemness signaling
Hweijan Hsu, Academia Sinica, Taiwan

Inorganic polyphosphate (POLYP): a key molecule of mammalian mitochondrial protein homeostasis
Pedro Urquiza, Rutgers University, USA

Inorganic polyphosphate and mitochondrial function in Alzheimer's disease
Mariona Guitart-Mampel, Rutgers University, USA

Inhibition of mitochondrial calcium uptake protects against Erastin-induced ferroptosis
Amalia Dolga, University of Groningen, Germany

Mitochondrial dysfunction underlies the comorbidity between Sporadic inclusion body myositis (sIBM) and other degenerative and age-related disorders
Gloria Garrabou, Institut D'investigacions Biomèdiques August Pi i Sunyer, Spain

Defining the ATPome reveals cross-optimization of metabolic pathways
Neal Bennett, Gladstone Institutes, USA

Modeling sporadic inclusion body myositis with fibroblasts
Judith Cantó-Santos, Institut D'investigacions Biomèdiques August Pi i Sunyer, Spain

Oxidized LDL and acetylated LDL are distinct in their effects on mitochondrial function in THP-1 macrophages
Pierre-Hadrien Becker, Unversité Paris Saclay, France

DRP1 regulates nucleoid segregation by modifying endoplasmic reticulum structure
Hema Saranya Ilamathi, the University of Quebec In Trois-Rivieres, Canada

It takes two to tango: metabolic deregulation in the B cell compartment as driving force for altered B Cell function in HIV-1 infected individuals
Maria Maddalena Perra, University Hospital Lausanne, Switzerland

Proteomic analysis of HABP1 overexpression in murine fibroblast reveals altered redox signaling leading to mitochondrial dysfunction
Ilora Ghosh, Jawaharlal Nehru University, India

Diverse effects of mitochondrial Lon protease in the stress response of Caenorhabditis Elegans
Eleni Kyriakou, Biomedical Research Foundation of the Academy of Athens, Greece

Understanding the molecular basis for ‘bizarre’ human mitochondrial tRNA recognition
Bernhard Kuhle, The Scripps Research Institute, USA

Heterogenous expression of DRP1 variants regulate mitochondrial dynamics in ovarian cancer
Zaineb Javed, Penn State College of Medicine, USA

Mitochondrial endonuclease g is important for tRNA THR processing and mitochondrial respiration
Jay Chung, National Institutes of Health, USA

End of the first day


Friday, October 30, 2020
Targeting Mitochondria 2020 Agenda
- Day 2 -

Session 4 - Symposium: Non-Coding RNAs in Nuclear-Mitochondrial Crosstalk: Applications for RNA Medicine
Chairpersons: Eric Barrey, GABI & (INRAE) and Nina Entelis (UNISTRA) - France


Introduction: Variety of non-coding RNA imported and encoded in mitochondria
Eric Barrey, University Paris-Saclay, INRAE, AgroParisTech, France

Molecular mechanisms of ncRNAs transport into mitochondria: emerging approaches and potential gene therapy applications
Nina Entelis, UNISTRA, France

Nuclear-Mitochondrial Communication through microRNA
Samarjit Das, Johns Hopkins School of Medicine, USA

Long non-coding RNA SAMMSON and beyond: uncoupling cytosolic and mitochondrial-translation as an effective anti-melanoma strategy
Eleonora Leucci, Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, Belgium

Targeting long non-coding mitochondrial RNA for cancer therapy
Veronica Burzio, Universidad Andrés Bello, Fundación Ciencia & Vida, Andes Biotechnologies, Republic of Chile

A mild pathology for a "bad" mutation in a noncoding mitochondrial RNA: homoplasmic tRNAPromutation causing exercise intolerance
Ivan Tarassov, UNISTRA, Strasbourg, France


Session 5 - Strategies to Target Mitochondria:
Clinical Trials and Potential Mitochondria-based Therapies


Neurodegeneration and Mitochondria
Ming Guo,
UCLA David Geffen School of Medicine, USA

Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis
Don Mahad, University of Edinburgh, United Kingdom


Short Oral Presentations of Day 2:

Mitochondrial transfer for the treatment of human diseases
Haya Lorberboum-Galski,
Hebrew University of Jerusalem, Israel

Transfer of mitochondria between airway smooth muscle cells in COPD
Julia Frankenberg Garcia, Imperial College London, United Kingdom

Metabolic reconfiguration in human skin fibroblasts as a tool for personalized mitochondrial medicine
Teresa Cunha-Oliveira, Center For Neuroscience And Cell Biology, Portugal

Targeting the mitochondrial protein MitoNEET with NL-1 provides protection in cerebral ischemic re-perfusion-injury
Werner Geldenhuys, West Virginia University, USA

Low 3-Hydroxyisobutyrate (3-HIB) and high methylmalonic Acid (MMA) levels in plasma reflect increased hepatic fatty acid oxidation
Mona Synnøve Nilsen, University of Bergen, Norway

Liposomes and mesoporous silica nanoparticles non-covalently modified with triphenylphosphonium cation
Lucia Zakharova, FRC Kazan Scientific Center of RAS, Russian Federation

Mitochondria: A potential target for adaptation in Ladakhis
Swati Sharma, Panjab University, India

Nuclear-mitochondrial communication involving miR-181C plays a pivotal role in cardiac dysfunction during obesity
Barbara Roman, Johns Hopkins School of Medicine, USA

18:00 End of Targeting Mitochondria 2020


Poster Presentations Accepted (Posters ordered by the last name)

Proteins as a target of cardioprotective regulation in conditions of reduced mitochondrial oxygen consumption
Natalia Andelova, Center of Experimental Medicine SAS, Slovak Republic

NKT cells enhance the metabolic activity and flexibility of CD8+ T CELLS
Ann-Kathrin Baumgart, University Hospital Bonn, Germany

Papaverine and its novel derivative SMV-32 alleviate tumor hypoxia by inhibiting mitochondrial metabolism
Martin Benej, Ohio State University, USA

Mitochondrial DNA deletions in leukocytes of adult subjects with intellectual disability are more frequent than in healthy controls
Bengisu Kevser Bulduk, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), Spain

A hypomorphic mouse model identified FIS1 as a required protein for mitochondrial ultrastructure and function
Tiago Alexandre Branco Fonseca, Tiago Alexandre, University of Padova, Italy

Metabolic derangement in PKD1 mouse models are ameliorated by mitochondrial-targeted antioxidants
Nastaran Daneshgar, Nastaran, University of Iowa, USA

Comparison of mitochondrial sequences obtained by two sequencing methods: long reads (oxford nanopore technology-ONT) versus short reads (Illumina) sequencing technologies
Sophie Dhorne-Pollet, INRAE, France

Mitochondrial function in different forms of Anemia
Christine Fischer, Medical University Innsbruck, Austria

Mitochondrial spare respiratory capacity (SRC): A new predictive metabolic biomarker for aggressiveness of Acute Myeloid Leukemia
Quentin Fovez, UMR9020 (CNRS) - UMR-S 1277 (INSERM) - CANTHER, France

Role of mitochondrial inorganic polyphosphate in maintaining mammalian cell bioenergetics
Vedangi Devendra Hambardikar, Rutgers University, USA

Basal mitochondrial electron transport chain activity determines mitochondrial stress response and cell proliferation by molecular hydrogen
Tomoya Hasegawa, Nagoya University, Japan

Effects of O-GlcNAcylation on functional mitochondrial transfer from Astrocytes

Kazuhide Hayakawa, Massachusetts General Hospital, USA

Inhibition of cytochrome C oxidase activity by GIIA secreted phospholipase A2 may induce neurodegeneration
Adrijan Ivanušec, Jozef Stefan Institute, Slovenia

Cell-type specific and Myelin-dependent subcellular distribution of axonal mitochondria
Koen Kole, Netherlands Institute for Neuroscience, The Netherlands

Molecular hydrogen as signaling molecule and factor reducing hydroxyl radicals - review
Krzysztof Piotr Michalak, Adam Mickiewicz University of Poznań, Poland

Revascularization by CABG following non-st-elevation acute coronary syndrome is associated with myocardial increase in ROS
Ivan Mihanović, University of Split School of Medicine, Croatia

Mitochondrial biogenesis during differentiation of pluripotent stem cells toward cardiomyocytes
Sepideh Mostafavi, University of Bergen UiB, Norway

Mitochondrial transfer of mesenchymal stem cell derived-mitochondria to human T lymphocytes confers protection against apoptosis
Eliseo Parra, Universidad de Los Andes, Santiago, Chile., Chile

Brain mitochondrial respiration becomes deteriorated in female C3H mice during aging, but not in males
Pavel V. Pchelin, Privolzhsky Research Medical University, Russian Federation

Mitochondrial signature in human monocytes and resistance to infection in C. Elegans during fumarate- induced innate immune training
Celia Angélica Pérez Hernández, Instituto Politécnico Nacional, Mexico

SHETA2-mediated mitochondrial dysfunction induces caspase-independent cell death in cervical cancer cell
Rajani Rai, OUHSC, USA

Association between Hexokinases and Oxphos in KRAS mutated colon cancer tumours
Egle Rebane-Klemm, Tallinn University of Technology, Estonia

Use of WES in the genetic diagnosis of diseases with suspected mitochondrial involvement
María Elena Rodríguez-García, Instituto de Investigación Hospital 12 de Octubre (i+12), Spain

Oxidant/Antioxidant imbalance in lymphoblasts from amyotrophic lateral sclerosis patients with SOD1 mutations and unknown mutations
Filomena Sg Silva, CNC - Center for Neuroscience and Cell Biology, Portugal

Rewiring of AMPK-mediated lipid metabolism to augment apoptotic potency in pancreatic cancer using anti-mitochondrial therapy
Yong Teng, Augusta University, USA

Bedaquiline has neuroprotective properties in ischemia-reperfusion caused brain injury
Danielius Umbrasas, Lithuanian University of Health Sciences, Lithuania

Improvement of mitochondrial integrity following silicone explantation: Autoimmune/inflammatory syndrome induced by adjuvants (ASIA)
Charmaine Van Eeden, University of Alberta, Canada

Mitochondrial proteostasis requires genes encoded in a neurodevelopmental syndrome locus
Meghan E. Wynne, Emory University, USA



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