Redox Signaling Pathways Modulation and Mitochondria: Hot Topic to be discussed during Targeting Mitochondria 2013
During ISANH Congress on Antioxidants organized in Paris on July 3-4, 2013 (www.isanh.fr), which celebrate the 15th Anniversary of the creation of ISANH, one of the main discussion showed that antioxidants play their role by modulating redox signaling pathways and not a counter "balance" to oxidant formation. They act to modulate cells signaling domains in which redox signaling occurs.
Mitochondria are a localized signlaing domain and ROS (Superoxidase and Hydrogen Peroxidase) generated by respiratory chain are signaling molecules.
The question is how mitochondria play a strategic role to MODULATE or RESTORE or RESET the redox signaling pathways?
Other question: how mitochondria can affect transcription factors like Nrf2-Keap1 and finally activate and modulate antioxidants genes expression?
In pathological conditions, such as neurodegenerative diseases, how can we restore or modulate signaling pathways?
Can we use exogenous antioxidants to target mitochondria, to modulate the redox state of cells and reduce oxidative damages at the level of mitochondrion?
Microbiota, Intestinal Redox Biology & Mitochondria: A Promising Target
One of the target and strategy for 2013 conference will be microbiota and mitochondrial physiopathology. The scientific committee decided to add a session in Targeting Mitochondria conference dedicated to Microbiota, Intestinal Redox Biology & Mitochondria: A Promising Target.
For more information: www.targeting-mitochondria.com
