Optimization of Energy Homeostasis in Old Age by SIRT6
Prof. Haim Cohen, head of the Molecular Mechanism of Aging Laboratory at Bar-Ilan University, Israel will be joining the Targeting Mitochondria 2021 Congress and give a presentation entitled "Optimization of Energy Homeostasis in Old Age by SIRT6".
Prof. Cohen's Studies in model organisms showed that the activity of the Sir2 family of NAD+-dependent protein deacetylases (sirtuins) is important in regulating lifespan in yeast, worms, and flies. He shows that overexpression of mammalian sirtuin SIRT6 in mice leads to a reduction in frailty and lifespan extension by ~30%. To do so, SIRT6 restores energy homeostasis of old animals through an improvement in the utilization of two major gluconeogenic precursors, lactate and glycerol.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
