ISANH and Scientific Committee of Targeting Mitochondria 2011 Awarded Dr Arduino for her work
During Targeting Mitochondria 2011, the Scientific Committee awarded three researchers for their innovative projects.
SIRT2 Deacetylase activity controls the autophagy-lysosomal system by modulating the acetylation of tubulin cytoskeleton.
Dr Daniela Arduino, from Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, was awarded for her scientific contribution for her work about SIRT2 DEACETYLASE ACTIVITY CONTROLS THE AUTOPHAGY-LYSOSOMAL SYSTEM BY MODULATING THE ACETYLATION DYNAMICS OF TUBULIN CYTOSKELETON.
More information about this work:
In Parkinson’s disease, mutational mtDNA signatures translate into mitochondrial dysfunction. We found that, under these conditions,
an impairment of microtubule- dependent trafficking ensues, perceived by excessive deacetylation of tubulin cytoskeleton by SIRT2.
This will compromise autophagy, and thus, the clearance of damaged organelles and protein aggregates.
We envision that targeting mitochondria- and/or SIRT2-associated processes can be a novel promising therapeutic approach for PD pathology.
