Who Controls NAD⁺? Mitochondria as Gatekeepers of Cellular Metabolism and Therapeutic Response
Prof. Mathias Ziegler from the University of Bergen, Norway will join the 17th WMS World Congress - Targeting Mitochondria 2026 and will present a talk entitled "Who Controls NAD⁺? Mitochondria as Gatekeepers of Cellular Metabolism and Therapeutic Response".
Most biological processes require energy and are tightly regulated. Energy is extracted from food supplies and eventually transformed into ATP. These pathways consist of many reactions which involve NAD or NADP, small molecules which serve as intermediate energy transmitters. Vitamin B3 is essential for the synthesis of these nucleotides. Interestingly, the key molecules in energy transduction also have important roles in the regulation of all vital cellular activities.
NAD-dependent signaling processes are mediated by PARPs, Sirtuins or NAD glycohydrolases by posttranslational modifications or the generation of messenger molecules. Our current work is aimed at further dissecting the molecular mechanisms of this network connecting cellular energy and signaling transmission. We are particularly fascinated by the dual roles not only of NAD, but also other cofactors such CoA, FAD or S-adenosyl methionine and the interaction of these molecules in metabolism and signaling.
