Fighting Fire with Fire: Boosting T Cell Therapy by Intercellular Mitochondrial Transfer

Presentation Key Points

• Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies.
• Bone marrow stromal cells (BMSCs) form nanotubular connections with T cells, enabling mitochondrial transfer into T cells.
• Transferred mitochondria enhance T cell mitochondrial mass and metabolic fitness.
• Mitochondria-boosted T cells exhibit resistance to exhaustion and demonstrate superior antitumor activity.