A Chimera that Breaches Mitochondria

 

A Chimera that Breaches Mitochondria
A milestone in mitochondrial biology

A research team from the University Medical Center Göttingen has developed a synthetic chimera that can cross both mitochondrial membranes and selectively block mitochondrial protein synthesis—without altering nuclear DNA.

For the first time, scientists can now disable one mitochondrial protein at a time in living cells, enabling real-time study of bioenergetics, redox balance, and disease pathways.

This innovation bypasses long-standing genetic barriers and opens new possibilities for studying and treating mitochondrial dysfunction in aging, neurodegeneration, and metabolic disease.