Electron microscopy showed EVs of typical size and morphology
News Release, Wolrd Mitochondria Society, Berlin - Germany – March 10, 2022
The accumulation of oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a major role in aging, "the mitochondrial free radical theory of aging". Circulating cell-free mtDNA (ccf-mtDNA) in blood can be considered as disease biomarkers.
Extracellular vesicles (EVs), the small lipid-bound vesicles capable of shuttling cargo, take part in intercellular communication systems.
In thier fascinating research, Lazo et al.:
They reported the following:
In conclusion, their results suggested that plasma mtDNA is present in EVs, that the level of EV-derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age-dependent manner.
In Targeting Mitochondria 2022, a whole session will be dedicated to Extracellular Vesicles & Mitochondria: The Target, in which Dr. Marc Germain and Dr. Devika S. Manickam will share with us their
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