The Mitochondria–Lysosome Axis: A New Dimension in Cellular Resilience and Disease
We are pleased to announce that Prof. Jiajie Diao will join Targeting Mitochondria 2026 as a speaker.
The acidic environment of the lysosomal lumen is essential for lysosomal digestive function. However, the source of protons that drive lysosomal acidification has remained unclear.
Here, we found that lysosomal content degradation is enhanced at mitochondria–lysosome contact (MLC) sites as a result of increased lysosomal acidification, and further observed proton flux from mitochondria to lysosomes at these sites. Under disease conditions, MLC formation is impaired; however, physically bringing mitochondria and lysosomes into close proximity restored lysosomal acidification and enhanced content digestion under disease-relevant conditions.
Together, these findings reveal a previously unrecognized physiological role of the mitochondria–lysosome axis in regulating lysosomal function and cellular homeostasis.
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