Correcting human mitochondrial mutations with targeted RNA import: A hot topic presented by M. Teitell during Targeting Mitochondria 2012

Mutations in the human mitochondrial genome are implicated in neuromuscular diseases, metabolic defects, and aging.

An efficient and simple mechanism for neutralizing deleterious mitochondrial DNA (mtDNA) alterations has unfortunately remained elusive. The new study published by M. Teitell and al. indicates that a wide range of RNAs can be targeted to mitochondria by appending a targeting sequence that interacts with PNPASE, with or without a mitochondrial localization sequence, providing an exciting, general approach for overcoming mitochondrial genetic disorders.

During Targeting Mitochondria 2012, which will be held in berlin in November 8-9, Michael Teitell will discuss about his recent publication and give a talk about Correcting Human Mitochondrial Mutations with Targeted RNA Import: Recent Advances and Perspectives for Mitochondria Medicine

To know more about complete program of Targeting Mitochondria 2012: www.targeting-mitochondria.com